Journal of Uludağ University Medical Faculty 1300-414X 2645-9027 Bursa Uludağ University 10.32708/uutfd.1757844 Haematology Hematoloji Mantle Hücreli Lenfomada Kemoterapi Rejimlerinin Etkinliği: Tek Merkez Deneyimi Efficacy of Chemotherapy Regimens in Mantle Cell Lymphoma: A Single Center Experience https://orcid.org/0000-0001-7336-2342 Aşık Mehmet Ali Medical Park Adana Hastanesi, Adana, Türkiye https://orcid.org/0000-0001-9710-134X Özkalemkaş Fahir Bursa Uludağ University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Bursa, Türkiye https://orcid.org/0000-0003-0014-7398 Ozkocaman Vildan Bursa Uludağ University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Bursa, Türkiye 12 08 2025 51 3 411 417 08 04 2025 09 23 2025 Copyright © 1975, Journal of Uludağ University Medical Faculty 1975 Journal of Uludağ University Medical Faculty

Bu tek merkezli çalışma, Mantle Hücreli Lenfoma (MHL) hastalarının klinik özelliklerini, tedavi yanıtlarını ve sağkalım sonuçlarını değerlendirmektedir. Ocak 2000 ile Aralık 2014 tarihleri arasında Bursa Uludağ Üniversitesi Tıp Fakültesi Hematoloji bölümünde tedavi edilen 25 MCL hastasını retrospektif olarak analiz ettik. Hastaların median takip süresi 37 (min-max=6-132) aydı. Kohortun çoğunluğu erkekti (%84) ve %92’si ileri evre hastalıkla başvurdu. Birinci basamak kemoterapiye genel yanıt oranı %72 idi ve 9 (%36) hastada tam remisyon sağlanmıştı. Progresyonsuz sağkalım (PFS) medyan 17 (min-max=2–39 ay) aydı ve 3 ve 5 yıllık genel sağkalım (OS) oranları sırasıyla %52 ve %28 idi. İkinci basamak tedavi gerektiren dokuz hastadan üçü (%33) kısmi remisyonda iken, üçü (%33) yanıtsızdı; kalan üç hasta ise yanıt değerlendirmesi yapılmadan önce hayatını kaybetmişti. İkinci basamak tedavi ile medyan progresyonsuz sağkalım (PFS) 6 ay olarak saptandı. Yedi (%28) hastaya otolog hematopoietik kök hücre nakli (OHKHN) yapılmıştı. OHKHN uygulanan grup, nakil yapılmayan hastalara kıyasla anlamlı derecede daha gençti (p=0,047) ve medyan genel sağkalım (OS) süresi anlamlı olarak daha uzundu (p

This single-center study evaluates the clinical characteristics, treatment responses, and survival outcomes of patients with Mantle Cell Lymphoma (MCL). We retrospectively analyzed 25 patients with MCL treated at the Hematology Department of Bursa Uludag University between January 2000 and December 2014. The median follow-up was 37 months min-max=6-132). The cohort was predominantly male (84%), with 92% presenting with advanced-stage disease. The overall response rate to first-line chemotherapy was 72%, with 9 patients (36%) achieving complete remission. The median progression-free survival (PFS) was 17 months (range, 2–39), and the 3- and 5-year overall survival (OS) rates were 52% and 28%, respectively. Among nine patients requiring second-line therapy, three (33%) achieved partial remission, while three (33%) had no response; the remaining three patients died before response assessment. The median PFS with second-line treatment was 6 months. Seven (28%) patients underwent autologous hematopoietic stem cell transplantation (AHSCT). The AHSCT cohort was significantly younger (p=0.047) and demonstrated a significantly longer median OS (p

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