van vet j Van Veterinary Journal 2149-3359 2149-8644 Van Yuzuncu Yıl University 10.36483/vanvetj.1385092 Veterinary Surgery Veteriner Cerrahi Ratlarda İntrabdominal Adezyonların Üzerine Trombositten Zengin Plazma’nın Etkisi Effect of Platelet Rich Plasma on Intraabdominal Adhesions in Rats https://orcid.org/0000-0001-5026-9559 Köm Mustafa Fırat Üniversitesi https://orcid.org/0009-0005-4223-3560 Akay İlyas https://orcid.org/0000-0002-3999-1310 Polat Eren https://orcid.org/0000-0003-2160-7453 Çalık İlknur 03 29 2024 35 1 1 6 11 02 2023 12 20 2023 Copyright © 1990, Van Veterinary Journal 1990 Van Veterinary Journal

Cerrahi alanındaki teknolojik gelişmelere rağmen intraabdominal adezyonlar; kısırlık, abdominaopelvik ağrı ve bağırsak tıkanıklıklarının en önemli nedenlerinden biridir. Bu çalışmada; trombositten zengin plazma (PRP)’nin intraabdominal adezyonların önlenmesindeki etkinliğinin ortaya konulması amaçlandı. Çalışmada 4 aylık 25 adet erkek Spraque Dawley ırkı rat kullanıldı. Ratlar her grupta 10 rat olmak üzere iki eşit gruba ayrıldı. Beş rat ise donör olarak kullanıldı. Bu ratlardan elde edilen kanlardan RRP hazırlandı. Genel anestezi altında operasyonlar klasik cerrahi kurallar altında iliosekal bölge açığa çıkarıldı ve 1 cm2’lik bir bölge travmatize edildi. Birinci grup kontrol olarak değerlendirildi ve herhangi bir kimyasal uygulanmadı. İkinci gruptaki ratlara PRP 0.4 ml dozunda lokal olarak uygulandı. Postoperatif 14. günde relaparatomi yapıldı. Sonuçlar makroskopik ve histopatolojik olarak değerlendirildi. PRP grubunun adezyon derecesi ve fibrozis dereceleri kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı olduğu saptandı (p0.05). Sonuç olarak, PRP’nin intraabdominal adezyonları önlemede daha etkili olduğu saptandı.

Despite the development of surgical technologies, intraabdominal adhesions are one of the most important problems for infertility, abdominopelvic pain, and intestinal obstruction. This study was aimed the efficiency of PRP (Platelet Rich Plasma) on preventing postoperative intraabdominal adhesions. In this study, 25 male Sprak Dawley breed rats of 4 months old were used. They were divided into 2 groups equally. Five rats were used as donor and obtained PRP. Following general anesthesia and under routine procedures, all groups were traumatized 1 cm2 area on the ileocecal region while group 1 was served as control with no chemical, the group 2 was locally applied PRP. Relaparatomy was made on the 14 days after surgery The results were evaluated macroscopically and histopathologically. Adhesion and fibrosis scores of PRP group were observed to have significantly decreased compared to the control (p0.05). In conclusion, it was determined that PRP was nore effective on the preventive of intraabdominal adhesions.

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