Maternal stres yenidoğan nöroblastomu nedenlerinden birisi midir?

Egemen Eroğlu; Gülnihal Şarman; Pınar Dayanıklı; Nur Danişmend; Rejin Kebudi; İnci Yıldız

doi:10.16948/zktb.64216

Is maternal stress among the causes of newborn neuroblastoma?

Year 2010, Volume: 41 Issue: 1, 9 - 12, 01.02.2010

Egemen Eroğlu Gülnihal Şarman Pınar Dayanıklı Nur Danişmend Rejin Kebudi İnci Yıldız

Abstract

Introduction and Aim: Previous studies have investigated the association between several perinatal factors and the risk of newborn neuroblastoma, but none of these studies have investigated the effect of maternal emotional experiences. The aim of this study is to attract attention to the possible relation between the fear induced maternal stress and newborn neuroblastoma. Material and Methods: The files of three newborn neuroblastoma patients were analyzed and the mothers were questioned to investigate the presence of emotional stress during the pregnancy period. Results: Diagnosis of all babies was discovered in the first two weeks of life. The babies were normal during the prenatal sonographic examinations. Just one month prior to delivery, all mothers experienced severe stress. Two of the mothers were involved in a car accident, and the other experienced severe distress because she was involved in an accident where her son was hurt. In two cases the tumor was surgically removed. These infants are disease free two and three years after the surgery. Complete removal was not successful in the third case, and chemotherapy had to be performed. Four years after chemotherapy, the patient was diagnosed with myelodysplastic syndrome and then secondary leukemia and is now undergoing treatment. Conclusion: Because of the rarity of neonatal neuroblastomas, it is clear that multicenter studies are necessary to understand the epidemiologic background and to develop optimal treatment protocols.

Keywords

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References

1. Moore SW, Satge D, Sasco AJ, et al. The epidemiology of neonatal tumors. Pediatr Surg Int 2003; 19: 509-519
2. Barson AJ. Congenital neoplasia: The society s experience. Arch Dis Child 1978; 53: 436
3. Harms D, Schmidt D, Leuschner I. Abdominal, retroperitoneal and sacrococcygeal tumoursnof the newborn and the very young infant. Report from the Kiel Paediatric Tumor Registry. Eur J Pediatr 1989; 148: 720-728
4. Büyükpamukçu M, Varan A, Tanyel C, et al. Solid tumors in the neonatal period. Clin Pediatr (Phila) 2003; 42:29-34
5. Rao S, AzmyA, CarachiR Neonatal Tumors: a single-centre experience. Pediatr Surg Int 2002; 18:306-309
6. Michalowski MB, Rubie H, Michon J, et al. Groupe Neuroblastome de la Societe Francaise d'Oncologie Pediatrique: Neonatal localized neuroblastoma: 52 cases treated from 1990 to 1999. Arch Pediatr 2004; 11:782-788
7. Sul HJ, Kang D. Congenital neuroblastoma with multiple metastases. A case report. J Korean Med Sci 2003; 18: 618-620
8. Olgun N, Turkish Pediatric Oncology Group. An intermediate analysis of the neuroblastoma treatment protocol-2003 of the Turkish Pediatric Oncology Group. J Pediatr Hemat Oncol 2007; suppl 1: 29:14
9. Albert A, Cruz O, Montaner A, et al. Congenital solid tumors. A thirteen year review. Cir Pediatr 2004; 17: 133-136
10. Parkes SE, Muir KR, Southern L, etal. Neonatal tumors: A thirty year population based study. Med Pediatr Oncol 1994; 22:309-317
11. Moppett J, Haddadin I, Foot ABM. Neonatal Neuroblastoma. Arch Dis Child Fetal Neonatal Ed 1999; 81:134-137
12. Buck GM, Michalek AM, Chen CJ, et al. Perinatal factors and risk of neuroblastoma. Paediatr Perinat Epidemiol. 2001; 15: 47-53
13. McCall EE, OlshanAF, Daniels JL. Maternal hair dye use and riskof neuroblastoma in offspring. Cancer Causes Control 2005; 16: 743-748
14. Cook MN, Olshan AF, Guess HA, etal. Maternal medication use and neuroblastoma in offspring. Am J Epidemiol 2004; 159: 721-731
15. Hamrick SE, Olshan AF, Neglia JP, et al. Association of pregnancy history and birth characteristics with neuroblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group. Paediatr Perinat Epidemiol 2001; 15:328-337
16. Johnson CC, Spitz MR. Neuroblastoma: case- control analysis of birth characteristics. Journal of the National Canceer Institude 1985; 74:789- 792
17. De Bernardi B, Di Tullio MT, Cordero di Montezemelo L, et al. Neuroblastoma under 1 year of age. Contrib Oncol 1990; 41:118-128
18. Considerations regarding the influence of intrauterine and early postnatal diseases and nutritional deficiencies on immunity and disease epidemiology (author's transl)]Immun Infekt. 1976; 4:229-235
19. Avitsur R, Hunzeker J, Sheridan JF. Rule of early stress in the individual differences in host response to viral infection. Brain Behav Immun, Epub November 10, 2005
20. Denver RJ, Crespi EJ. Stress Hormones and Human Developmental Plasticity. Lessons From Tadpoles. Neoreviews 2006; 7:183-188

Maternal stres yenidoğan nöroblastomu nedenlerinden birisi midir?

Year 2010, Volume: 41 Issue: 1, 9 - 12, 01.02.2010

Egemen Eroğlu Gülnihal Şarman Pınar Dayanıklı Nur Danişmend Rejin Kebudi İnci Yıldız

Abstract

Giriş ve Amaç: Daha önce yapılan çalışmalarda çeşitli perinatal faktörlerle yenidoğan nöroblastom riski arasındaki bağlantı araştırılmış, ancak bu çalışmaların hiçbirisi annenin duygusal deneyimlerinin etkisini araştırmamıştır. Bu çalışmanın amacı annenin çok korkmasına bağlı oluşan stresle yenidoğan nöroblastomu arasındaki olası bağlantıya dikkat çekmektir. Gereç ve yöntem: Yenidoğan nöroblastomlu üç olgunun dosyaları incelenmiş, annelerinin perinatolojik dönemde yaşadıkları duygusal deneyimler sorgulanmıştır. Bulgular: Bebeklerin hepsinin tanısı ilk iki hafta içerisinde konulmuştur. Perinatolojik takipleri tamamen normal olan hastaların anneleri son gebelik ayında ciddi bir korkma anı yaşayarak strese maruz kalmışlardır, iki anne trafik kazasına uğramış, diğer annenin ise çocuğu bisikletle annenin gözü önünde kaza geçirmiştir. İki hastada tümör tamamen çıkarılabilmiştir. Bu iki hasta ameliyattan sonra ikinci ve dördüncü yıllarında sorunsuz takip edilmektedir. Üçüncü hastada cerrahi olarak tam çıkarlamamış, ve kemoterapi uygulanmak zorunda kalınmıştır. Kemoterapiden dört yıl sonra myelodisplastik sendrome ve ikincil lösemi tanıları konulmuştur. Hasta halen tedavi altındadır. Sonuç: Çok nadir tümörler olduklarından etkin kemoterapi protokollerini oluşturmak ve epidemiyolojik tabanı saptayabilmek için daha çok merkezli çalışmalara ihtiyaç duyulmaktadır.

Keywords

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References

1. Moore SW, Satge D, Sasco AJ, et al. The epidemiology of neonatal tumors. Pediatr Surg Int 2003; 19: 509-519
2. Barson AJ. Congenital neoplasia: The society s experience. Arch Dis Child 1978; 53: 436
3. Harms D, Schmidt D, Leuschner I. Abdominal, retroperitoneal and sacrococcygeal tumoursnof the newborn and the very young infant. Report from the Kiel Paediatric Tumor Registry. Eur J Pediatr 1989; 148: 720-728
4. Büyükpamukçu M, Varan A, Tanyel C, et al. Solid tumors in the neonatal period. Clin Pediatr (Phila) 2003; 42:29-34
5. Rao S, AzmyA, CarachiR Neonatal Tumors: a single-centre experience. Pediatr Surg Int 2002; 18:306-309
6. Michalowski MB, Rubie H, Michon J, et al. Groupe Neuroblastome de la Societe Francaise d'Oncologie Pediatrique: Neonatal localized neuroblastoma: 52 cases treated from 1990 to 1999. Arch Pediatr 2004; 11:782-788
7. Sul HJ, Kang D. Congenital neuroblastoma with multiple metastases. A case report. J Korean Med Sci 2003; 18: 618-620
8. Olgun N, Turkish Pediatric Oncology Group. An intermediate analysis of the neuroblastoma treatment protocol-2003 of the Turkish Pediatric Oncology Group. J Pediatr Hemat Oncol 2007; suppl 1: 29:14
9. Albert A, Cruz O, Montaner A, et al. Congenital solid tumors. A thirteen year review. Cir Pediatr 2004; 17: 133-136
10. Parkes SE, Muir KR, Southern L, etal. Neonatal tumors: A thirty year population based study. Med Pediatr Oncol 1994; 22:309-317
11. Moppett J, Haddadin I, Foot ABM. Neonatal Neuroblastoma. Arch Dis Child Fetal Neonatal Ed 1999; 81:134-137
12. Buck GM, Michalek AM, Chen CJ, et al. Perinatal factors and risk of neuroblastoma. Paediatr Perinat Epidemiol. 2001; 15: 47-53
13. McCall EE, OlshanAF, Daniels JL. Maternal hair dye use and riskof neuroblastoma in offspring. Cancer Causes Control 2005; 16: 743-748
14. Cook MN, Olshan AF, Guess HA, etal. Maternal medication use and neuroblastoma in offspring. Am J Epidemiol 2004; 159: 721-731
15. Hamrick SE, Olshan AF, Neglia JP, et al. Association of pregnancy history and birth characteristics with neuroblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group. Paediatr Perinat Epidemiol 2001; 15:328-337
16. Johnson CC, Spitz MR. Neuroblastoma: case- control analysis of birth characteristics. Journal of the National Canceer Institude 1985; 74:789- 792
17. De Bernardi B, Di Tullio MT, Cordero di Montezemelo L, et al. Neuroblastoma under 1 year of age. Contrib Oncol 1990; 41:118-128
18. Considerations regarding the influence of intrauterine and early postnatal diseases and nutritional deficiencies on immunity and disease epidemiology (author's transl)]Immun Infekt. 1976; 4:229-235
19. Avitsur R, Hunzeker J, Sheridan JF. Rule of early stress in the individual differences in host response to viral infection. Brain Behav Immun, Epub November 10, 2005
20. Denver RJ, Crespi EJ. Stress Hormones and Human Developmental Plasticity. Lessons From Tadpoles. Neoreviews 2006; 7:183-188

There are 20 citations in total.

Details

Primary Language	Turkish
Journal Section	Articles
Authors	Egemen Eroğlu This is me Gülnihal Şarman This is me Pınar Dayanıklı This is me Nur Danişmend This is me Rejin Kebudi This is me İnci Yıldız This is me
Publication Date	February 1, 2010
Published in Issue	Year 2010 Volume: 41 Issue: 1

Cite

APA	Eroğlu, E., Şarman, G., Dayanıklı, P., Danişmend, N., et al. (2010). Maternal stres yenidoğan nöroblastomu nedenlerinden birisi midir?. Zeynep Kamil Tıp Bülteni, 41(1), 9-12. https://doi.org/10.16948/zktb.64216
AMA	Eroğlu E, Şarman G, Dayanıklı P, Danişmend N, Kebudi R, Yıldız İ. Maternal stres yenidoğan nöroblastomu nedenlerinden birisi midir?. Zeynep Kamil Tıp Bülteni. February 2010;41(1):9-12. doi:10.16948/zktb.64216
Chicago	Eroğlu, Egemen, Gülnihal Şarman, Pınar Dayanıklı, Nur Danişmend, Rejin Kebudi, and İnci Yıldız. “Maternal Stres yenidoğan nöroblastomu Nedenlerinden Birisi Midir?”. Zeynep Kamil Tıp Bülteni 41, no. 1 (February 2010): 9-12. https://doi.org/10.16948/zktb.64216.
EndNote	Eroğlu E, Şarman G, Dayanıklı P, Danişmend N, Kebudi R, Yıldız İ (February 1, 2010) Maternal stres yenidoğan nöroblastomu nedenlerinden birisi midir?. Zeynep Kamil Tıp Bülteni 41 1 9–12.
IEEE	E. Eroğlu, G. Şarman, P. Dayanıklı, N. Danişmend, R. Kebudi, and İ. Yıldız, “Maternal stres yenidoğan nöroblastomu nedenlerinden birisi midir?”, Zeynep Kamil Tıp Bülteni, vol. 41, no. 1, pp. 9–12, 2010, doi: 10.16948/zktb.64216.
ISNAD	Eroğlu, Egemen et al. “Maternal Stres yenidoğan nöroblastomu Nedenlerinden Birisi Midir?”. Zeynep Kamil Tıp Bülteni 41/1 (February 2010), 9-12. https://doi.org/10.16948/zktb.64216.
JAMA	Eroğlu E, Şarman G, Dayanıklı P, Danişmend N, Kebudi R, Yıldız İ. Maternal stres yenidoğan nöroblastomu nedenlerinden birisi midir?. Zeynep Kamil Tıp Bülteni. 2010;41:9–12.
MLA	Eroğlu, Egemen et al. “Maternal Stres yenidoğan nöroblastomu Nedenlerinden Birisi Midir?”. Zeynep Kamil Tıp Bülteni, vol. 41, no. 1, 2010, pp. 9-12, doi:10.16948/zktb.64216.
Vancouver	Eroğlu E, Şarman G, Dayanıklı P, Danişmend N, Kebudi R, Yıldız İ. Maternal stres yenidoğan nöroblastomu nedenlerinden birisi midir?. Zeynep Kamil Tıp Bülteni. 2010;41(1):9-12.