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Is there any Effect of Dinoprostone on Neonatal Jaundice ?

Year 2012, Volume: 43 Issue: 3, 78 - 83, 01.04.2012

Mehmet Akif Sargın Ali Gedikbaşı Asar Emel Canaz Taner Günay Dicle İrmak Sargın Yavuz Ceylan

Abstract

Introduction: Different mechanical and pharma- cological methods are commonly used in obstetri- cal practice for ripening the cervix before labor induction if the the cervix is unfavorable. All of labor induction methods have side effects. Neo- natal jaundice is one of these side effects. In our study, we searched the effect of dinoprostone that used in cervical ripening and labor induction , in regard of neonatal bilirubin levels. Material and methods: 68 preeclamptic preg- nants diagnosed between140 cases, who applied to the antenatal outpatient clinic, the perinatol- ogy outpatient clinic and emergency service be- tween March 2007- April 2008 and who didn’t have any contraindication for induction and any known risk factor for newborn jaundice, formed our study group. Of those cases, study groups were constructed by administering induction by dinoprostone in 48, by misoprostol in 46, and by oxytosin in 46 cases. A control group consisted of pregnant women, 44 of whom delivered a baby by cesarean section with an aprpointment and 47 by normal spontaneous delivery. Haemogram, blood groups and biochemistry were studied fom cord blood of all babies. Their total bilirubin levels were measured and compared at postpartum 3rd and 6th days. Results: There was no statistically significant dif- ference in 3rd and 6th day total bilirubin levels among study groups. These values were 8,23±3,96 and 7,36±4,66 mg/dl in oxytocin infusion group, 8,43±4,23 and 6,75±4,73 mg/dl in misoprostol group, 7,63±3,46 and 6,69±3,58 mg/dl in dino- prostone group, respectively (p>0.05). Those values were 7,46±2,04 and 8,22±4,15 mg/dl in section with appointment which formed the con- trol group and 8,7±4,14 and 7,43±4,64 mg/dl in normal spontaneous delivery group. There were no statistically significant difference between 3rd day and 6th day bilirubin values among study and control groups (p>0.05). Conclusion: As a result of evaluation of re- sults we obtained in our study with the litera- ture, administering intravaginal dinoprostone (PGE2) is a safe method for the aspect of newborn jaundice.

Keywords

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References

  • 1. Brindley BA, Sokol RJ. Induction and augmenta- tion of labor: basis and methods for current practice
  • Obstet Gynecol Surv. Dec 1988;43(12):730 743
  • 2. Kashanian M, Nazemi M, Malakzadegan A
  • Comparison of 30-mL and 80-mL Foley cath- eter balloons and oxytocin for preinduction cervical ripening. Int J Gynaecol Obstet. May 2009;105(2):174-175
  • 3. No. Obstetrics 107: Induction ACoPB--. of labor. ACOG Obstet Practice Gynecol. Bulletin Aug 2009;114(2 Pt 1):386-397
  • 4. Gynecologists ACoOa. ACOG Practice Bull etin No. 106: Intrapartum fetal heart rate moni- toring: nomenclature, interpretation, and gen- eral management principles. Obstet Gynecol. Jul 2009;114(1):192-202
  • 5. Catanzarite V, Cousins L, Dowling D, Danesh- mand S. Oxytocin-associated rupture of an un- scarred uterus in a primigravida. Obstet Gynecol
  • Sep 2006;108(3 Pt 2):723-725
  • 6. Davies GA, Tessier JL, Woodman MC, Lipson A, Hahn PM. Maternal hemodynamics after oxy- tocin bolus compared with infusion in the third stage of labor: a randomized controlled trial. Ob- stet Gynecol. Feb 2005;105(2):294-299
  • 7. Janakiraman V, Ecker J, Kaimal AJ. Compar- ing the second stage in induced and spontaneous labor. Obstet Gynecol. Sep 2010;116(3):606-611
  • 8. Fevery J. Bilirubin in clinical practice: a re- view. Liver Int. May 2008;28(5):592-605
  • 9. Bhutani VK, Johnson L, Sivieri EM. Predic- tive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbiliru- binemia in healthy term and near-term newborns
  • Pediatrics. Jan 1999;103(1):6-14
  • 10. ACOG technical bulletin. Induction of la- bor. Number 217--December 1995 (replaces no
  • 157, July 1991). American College of Obstetri- cians Gynecologists. Int J Gynaecol Obstet. Apr 1996;53(1):65-72
  • 11. Fisch JM, English D, Pedaline S, Brooks K, Simhan HN. Labor induction process improve- ment: a patientquality-of-care initiative . Obstet Gynecol 2009;113:797---803
  • 12. Woyton J, Agrawal P, Zimmer M. Evaluation of the effect of oxytocin use for labor induction on frequency of occurrence and severity of ne- onatal jaundice. Ginekol Pol. 1994;65(12):682-5
  • 13. Seidman DS, Ergaz Z, Paz I et al. Predicting the risk of jaundice in full-term healthy newborns: a prospective population-based study. J Perina- tol. 1999;19:564-7
  • 14. Kılıçdağ ve ark. Effects of Induction of La- bor With Oxytocin and Misoprostol on Neona- tal Bilirubin Levels. J Turkish-German Gyne- col Assoc, vol.8(1;2007) 15. Oral E, Gezer A, Cagdas A, Pakkal N. Oxy- tocin infusion in labor: the effect different indica- tions and the use of different diluents on neo- natal bilirubin levels. Arch Gynecol Obstet. Jan 2003;267(3):117-120
  • 16. Sahin HG, Kolusari A, Kamaci M, Kaynak C, Tuncel H. The effect of oxytocin infusion and mi- soprostol on neonatal bilirubin levels. Arch Gyne- col Obstet. Mar 2009
  • 17. Weekes AR, Beazley JM. Neonatal serum bi- lirubin levels following the use of prostaglandin E2 in labour. Prostaglandins. Oct 1975;10(4):699- 714
  • 18. Grünberger W. [Local application of PGE2 by means of a cervical cap for the in- duction of labor]. Wien Klin Wochenschr. Oct 1982;94(20):561-564

KTB Dinoproston’un Yenidoğan Sarılığına Etkisi Var mıdır?

Year 2012, Volume: 43 Issue: 3, 78 - 83, 01.04.2012

Mehmet Akif Sargın Ali Gedikbaşı Asar Emel Canaz Taner Günay Dicle İrmak Sargın Yavuz Ceylan

Abstract

Giriş: Obstetride, uygunsuz serviks varlığında doğum indüksiyonundan önce serviksin olgunlaştırılması için çeşitli farmakolojik ve mekanik yöntemler sıklıkla kullanılmaktadır. Tüm bu metodların çeşitli yan etkileri vardır. Yenidoğan sarılığı bu yan etkilerden birisidir. Biz çalışmamızda, servikal olgunlaşma ve doğum in- düksiyonunda kullanılan farmakolojik ajanlardan intravaginal dinoprostonun yenidoğan sarılığına etkisini araştırdık. Yöntem: Hastanemiz gebe izlem polikliniği ve acil doğum polikliniğine başvuran; doğum in- düksiyonu için kontrendikasyonu ve yenidoğan sarılığı için bilinen risk faktörü olmayan 140 gebe çalışma grubumuza dahil edildi. Bu grupta 48 ge- beye sadece dinoprostone ile, 46 gebeye sadece misoprostol ile ve 46 gebeye sadece oksitosin ile farmakolojik indüksiyon uygulandı. Elektif sez- eryan ile doğum yapan 44 gebe ve indüksiyon al- mayan, normal spontan doğum yapan 47 gebe ile kontrol grubu oluşturuldu. Tüm bebeklerin kor- don kanından kan grubu, hemogram ve biyokimya çalışıldı. Postpartum 3. ve 6.gün total bilirubin seviyeleri karşılaştırıldı. Bulgular: Çalışma gruplarının 3. ve 6. gün to- tal bilirubin seviyeleri arasında istatistiksel bir fark görülmedi. Sırasıyla oksitosin infüzyon grubunda 8,23±3,96 ve 7,36±4,66 mg/dl; miso- prostol grubunda 8,43±4,23 ve 6,75±4,73 mg/dl; dinoproston grubunda 7,63±3,46 ve 6,69±3,58 mg/dl bulundu (p>0.05). Bu değerler kontrol gruplarından elektif sezeryan grubunda 7,46±2,04 ve 8,22±4,15 mg/dl; normal spontan doğum grubunda 8,7±4,14 ve 7,43±4,64 mg/dl bulundu. Çalışma ve kontrol grubundaki hastaların 3. ve 6. gün total bilirubin seviyeleri arasında istatistiksel bir fark görülmedi (p>0.05). Sonuçlar: İntravaginal dinoproston (PGE2) kullanımı yenidoğan sarılığı açısından güvenli bir farmakolojik ajandır.

Keywords

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References

  • 1. Brindley BA, Sokol RJ. Induction and augmenta- tion of labor: basis and methods for current practice
  • Obstet Gynecol Surv. Dec 1988;43(12):730 743
  • 2. Kashanian M, Nazemi M, Malakzadegan A
  • Comparison of 30-mL and 80-mL Foley cath- eter balloons and oxytocin for preinduction cervical ripening. Int J Gynaecol Obstet. May 2009;105(2):174-175
  • 3. No. Obstetrics 107: Induction ACoPB--. of labor. ACOG Obstet Practice Gynecol. Bulletin Aug 2009;114(2 Pt 1):386-397
  • 4. Gynecologists ACoOa. ACOG Practice Bull etin No. 106: Intrapartum fetal heart rate moni- toring: nomenclature, interpretation, and gen- eral management principles. Obstet Gynecol. Jul 2009;114(1):192-202
  • 5. Catanzarite V, Cousins L, Dowling D, Danesh- mand S. Oxytocin-associated rupture of an un- scarred uterus in a primigravida. Obstet Gynecol
  • Sep 2006;108(3 Pt 2):723-725
  • 6. Davies GA, Tessier JL, Woodman MC, Lipson A, Hahn PM. Maternal hemodynamics after oxy- tocin bolus compared with infusion in the third stage of labor: a randomized controlled trial. Ob- stet Gynecol. Feb 2005;105(2):294-299
  • 7. Janakiraman V, Ecker J, Kaimal AJ. Compar- ing the second stage in induced and spontaneous labor. Obstet Gynecol. Sep 2010;116(3):606-611
  • 8. Fevery J. Bilirubin in clinical practice: a re- view. Liver Int. May 2008;28(5):592-605
  • 9. Bhutani VK, Johnson L, Sivieri EM. Predic- tive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbiliru- binemia in healthy term and near-term newborns
  • Pediatrics. Jan 1999;103(1):6-14
  • 10. ACOG technical bulletin. Induction of la- bor. Number 217--December 1995 (replaces no
  • 157, July 1991). American College of Obstetri- cians Gynecologists. Int J Gynaecol Obstet. Apr 1996;53(1):65-72
  • 11. Fisch JM, English D, Pedaline S, Brooks K, Simhan HN. Labor induction process improve- ment: a patientquality-of-care initiative . Obstet Gynecol 2009;113:797---803
  • 12. Woyton J, Agrawal P, Zimmer M. Evaluation of the effect of oxytocin use for labor induction on frequency of occurrence and severity of ne- onatal jaundice. Ginekol Pol. 1994;65(12):682-5
  • 13. Seidman DS, Ergaz Z, Paz I et al. Predicting the risk of jaundice in full-term healthy newborns: a prospective population-based study. J Perina- tol. 1999;19:564-7
  • 14. Kılıçdağ ve ark. Effects of Induction of La- bor With Oxytocin and Misoprostol on Neona- tal Bilirubin Levels. J Turkish-German Gyne- col Assoc, vol.8(1;2007) 15. Oral E, Gezer A, Cagdas A, Pakkal N. Oxy- tocin infusion in labor: the effect different indica- tions and the use of different diluents on neo- natal bilirubin levels. Arch Gynecol Obstet. Jan 2003;267(3):117-120
  • 16. Sahin HG, Kolusari A, Kamaci M, Kaynak C, Tuncel H. The effect of oxytocin infusion and mi- soprostol on neonatal bilirubin levels. Arch Gyne- col Obstet. Mar 2009
  • 17. Weekes AR, Beazley JM. Neonatal serum bi- lirubin levels following the use of prostaglandin E2 in labour. Prostaglandins. Oct 1975;10(4):699- 714
  • 18. Grünberger W. [Local application of PGE2 by means of a cervical cap for the in- duction of labor]. Wien Klin Wochenschr. Oct 1982;94(20):561-564
There are 22 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Mehmet Akif Sargın This is me

Ali Gedikbaşı This is me

Asar Emel Canaz This is me

Taner Günay This is me

Dicle İrmak Sargın This is me

Yavuz Ceylan This is me

Publication Date April 1, 2012
Published in Issue Year 2012 Volume: 43 Issue: 3

Cite

APA Sargın, M. A., Gedikbaşı, A., Canaz, A. E., Günay, T., et al. (2012). KTB Dinoproston’un Yenidoğan Sarılığına Etkisi Var mıdır?. Zeynep Kamil Tıp Bülteni, 43(3), 78-83. https://doi.org/10.16948/zktb.54531
AMA Sargın MA, Gedikbaşı A, Canaz AE, Günay T, Sargın Dİ, Ceylan Y. KTB Dinoproston’un Yenidoğan Sarılığına Etkisi Var mıdır?. Zeynep Kamil Tıp Bülteni. April 2012;43(3):78-83. doi:10.16948/zktb.54531
Chicago Sargın, Mehmet Akif, Ali Gedikbaşı, Asar Emel Canaz, Taner Günay, Dicle İrmak Sargın, and Yavuz Ceylan. “KTB Dinoproston’un Yenidoğan Sarılığına Etkisi Var mıdır?”. Zeynep Kamil Tıp Bülteni 43, no. 3 (April 2012): 78-83. https://doi.org/10.16948/zktb.54531.
EndNote Sargın MA, Gedikbaşı A, Canaz AE, Günay T, Sargın Dİ, Ceylan Y (April 1, 2012) KTB Dinoproston’un Yenidoğan Sarılığına Etkisi Var mıdır?. Zeynep Kamil Tıp Bülteni 43 3 78–83.
IEEE M. A. Sargın, A. Gedikbaşı, A. E. Canaz, T. Günay, D. İ. Sargın, and Y. Ceylan, “KTB Dinoproston’un Yenidoğan Sarılığına Etkisi Var mıdır?”, Zeynep Kamil Tıp Bülteni, vol. 43, no. 3, pp. 78–83, 2012, doi: 10.16948/zktb.54531.
ISNAD Sargın, Mehmet Akif et al. “KTB Dinoproston’un Yenidoğan Sarılığına Etkisi Var mıdır?”. Zeynep Kamil Tıp Bülteni 43/3 (April 2012), 78-83. https://doi.org/10.16948/zktb.54531.
JAMA Sargın MA, Gedikbaşı A, Canaz AE, Günay T, Sargın Dİ, Ceylan Y. KTB Dinoproston’un Yenidoğan Sarılığına Etkisi Var mıdır?. Zeynep Kamil Tıp Bülteni. 2012;43:78–83.
MLA Sargın, Mehmet Akif et al. “KTB Dinoproston’un Yenidoğan Sarılığına Etkisi Var mıdır?”. Zeynep Kamil Tıp Bülteni, vol. 43, no. 3, 2012, pp. 78-83, doi:10.16948/zktb.54531.
Vancouver Sargın MA, Gedikbaşı A, Canaz AE, Günay T, Sargın Dİ, Ceylan Y. KTB Dinoproston’un Yenidoğan Sarılığına Etkisi Var mıdır?. Zeynep Kamil Tıp Bülteni. 2012;43(3):78-83.