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Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep

Yıl 2019, Cilt: 16 Sayı: 1, 1 - 7, 25.03.2019
https://doi.org/10.32707/ercivet.538035

Öz

The aim of this study was to evaluate the sedative-anesthetic effects of detomidine (D) 30 µg/kg, intramuscular (IM), butorphanol (B) 0.2 mg/kg IM and ketamine (K) 5 mg/kg, IM combination in sheep. Five female and nine male healthy (1-2 years old) Akkaraman sheep were used as animal material. Detomidine and butorphanol were used to produce sedation. Ten minutes later K was administrated for anaesthesia. The anaesthetic effect of the drugs was reserved by atipamezole (AT) 30 µg/kg, IM administration at 30 minutes after K injection. The sedative effects of DB demerged in 3 minutes after injection and anaesthetic effects (by the lack of pain stimuli) were visible in 5 minutes after K injection. Heart rate, body temperature and amplitude P values significantly decreased until the administration of AT. Contrarily, respiratory rate, PR interval and R amplitude values increased during anesthesia. Partial venous oxygen pressure (PO2) and Partial venous carbon dioxide pressure (PCO2) values decreased during anaesthesia. There were no significant alterations seen for hematological parameters including hemoglobin (Hg), white blood cell (WBC), red blood cell (RBC) and hematocrit (Ht) values in sheep. As a result, BDK anaesthetic combination depresses the cardiorespiratoric system but produces adequate sedation and anaesthesia for sheep. AT can be safely used for this anaesthetic combination in sheep.

Kaynakça

  • 1- Atalan G, Uzun M, Demirkan I, Yıldız S, Cenesiz M. Effect of medetomidine-butorphanol-ketamine anaesthesia and atipamezole on heart and respiratory rate and cloacal tempature of domestic pigeons. J Vet Med A Physiol Pathol Clin Med 2002; 49(6): 281-5. 2- Aantaa R. Alpha-2 adrenoceptor antagonists. Bailliere’s Cinical Anaesthesiology 2000; 14: 285-92. 3- Chittick E, Horne W, Wolfe B, Sladky K, Loomis M. Cadiopulmonary assessment of medetomidine, ketamine, and butorphanol anaesthesia in Captive Thomson’s Gazelles (Gazella Thomsoni). J Zoo Wildl Med 2001; 32(2): 168-75. 4- Dart CM. Advantages and disadvantage of using alpha-2 agonists in veterinary practice. Aust Vet J 1999; 77(11): 720-2. 5- DiMaioKnych HK, Covamubias V, Steffey EP. Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse. Veterinary Anaesthesia Analgesia 2012; 39(6): 574-83. 6- Galotos AD. Anaesthesia and Analgesia in sheep and goats. Vet Clin Food Anim 2001; 27:47-59. 7- Hall LW, Clerk KW. Anaesthesia in dog. Hall LW, Clerk KW eds. In: Veterinary Anaesthesia. Philadelphia: Bailliere Tindall,1991, pp. 51-347. 8- Hall LW, Clerk KW, Trim CM. Anaesthesia of sheep, goats and other herbivores.Hall LW, Clerk KW, Trim CM eds. In: Veterinary Anaesthesia. England: W.B. Saunders, 2000,pp. 341-66. 9- Hartsfield SM. Advantages and guidelines for using ketamine for induction of anaesthesia. Vet Clin Small Anim 1992; 22: 266-7. 10- Howard BW, Lagutchik MS, Januszkiewicz AJ, Martin DG. The cardiovascular response of sheep to tiletamine-zolazepam and butorphanol tartrate anaesthesia. Vet Surg 1990; 19(6): 461-7. 11- Kariman A, Sharifi D, Nowrouzian I. Evaluation of detomidine hydrochloride, diazepam and thiopental sodium combination on cardiovascular function and hemodynamics in sheep. Small Ruminant Research 1998; 29(1):43-9. 12- Kastner SBR. Alpha2 agonists in sheep: A review. Veterinary Anaesthesia and Analgesia 1998; 33(2): 79-96. 13- Kastner SBR, Ohlerth S, Pospischil A, Boller J, Huhtinen MK. Dexmedetomidine induced pulmonary alterations in sheep. Res Vet Sci 2007; 83(2): 217-26. 14- Khan MA, Ashraf M, Pervez K, Rashid HB, Mahmood AK, Chaudhry M. Comparative effects of detomidine and xylazine as sedative and analgesic agents in small ruminants. Pak Vet J 2004; 24(2), 16-20. 15- Laitinen OM. Clinical observation on medetomidine/ketamine anaesthesia in sheep and its reversal by atipemazole. J Assoc Vet Anaest 1990;17:17-19. 16- Lin HC, Wallace SS, Tyler JW, Robbins RL, Thurmon JC, Wolfe DF. Comparasion of tilatamine-zolazepam-ketamine and tiletamine-zolezapam-ketamine-xylazine anaesthesia in sheep. Aust Vet J 1994;71(8): 239-42. 17- Lin HC, Prohit RC, Powe TA. Anaesthesia in sheep with propofol or with xylazine-ketamine followed by Halothane. Veterinary Anesthesia and Analgesia 1997;26(3):247-52. 18- Mahmood BM, Mohammad FK. Antagonism of medetomidine sedation in goats by atipamezole and yohimbine. Turk J Vet Anim Sci 2008; 32: 429-32. 19- Mama KR. Anaesthesic management of Horse: Intravenous Anaesthesia. http://www.ivis.org/advances/Steffey_Anesthesia/mama_horse/chapter_frm.asp?LA=1, Acces of date; 16.01.2009. 20- Nolan A, Livingston A, Waterman A. The effects of alpha-2 adrenoceptoragonists on airway pressure in anesthetized sheep. J Vet Pharmacol Therap 1986; 9: 157-63. 21- O’hair KC, Dodd KT, Philips YY, Beattie RJ. Cardiopulmonary effects of nalbuphine Hydrochloride and butorphanol tartrate in sheep. Lab Anim Sci 1988; 38(1): 58-61. 22- Onmaz AC, Gunes V, Atalan G, Gelfert CC, Atalan G. Comparasion of arterial and venous blood gas values in sheep before and during isoflurane anaesthesia. Revue Med Vet 2009; 160: 356-61. 23- Ranheim B, Arnemo JM, Stuen S, Horsberg TE. Medetomidine and atipamezole in sheep: Disposition and clinical effects. J Vet Pharmacol Therap 2000; 23(6): 401-4. 24- Short CE. Effects of anticholinergic treatment on the cardiac and respiratory systems in dogs sedated with medetomidine. Vet Rec 1991; 129(14): 310-13. 25- Thurmon JC, Kumar A, Link EP. Evaluation of ketamine hydrochloride as an anaesthetic in sheep. J Am Vet Med Assoc 1973; 162: 293-97. 26- Verstegen J, Petcho A. Medetomidine-butorphanol-midozalam for anaesthesia in dogs and its reversal by atipamezole. Vet Rec 1993; 132(14): 353-7. 27- Waterman AE, Nolan A, Livingston A. Influence of idazoxan on the respiratory blood gas changes induced by alpha2-adrenoceptor agonist drugs in conscious sheep. Vet Rec 1987; 121 (5): 105-7. 28- Waterman AE, Livingston A, Amin A. Analgesic activity and respiratory effects of butorphanol in sheep. Res Vet Sci 1991; 51(1): 19-23.

Koyunlarda Detomidin-Butarfanol-Ketamin ve Atipamezol’ün Klinik, Kardiyorespiratorik, Hematolojik Parametreler Üzerine Etkileri

Yıl 2019, Cilt: 16 Sayı: 1, 1 - 7, 25.03.2019
https://doi.org/10.32707/ercivet.538035

Öz

Bu çalışmanın amacı koyunlarda detomidin (D) 30µg/kg, intramüsküler (IM), butarfanol (B) 0.2 mg/kg, IM ve ketamin (K) 5 mg/kg, IM kombinasyonunun sedatif-anestezik etkilerinin değerlendirilmesidir. Beş dişi ve dokuz erkek (1 -2 yaşlı) Akkaraman koyunu çalışma materyali olarak kullanıldı. Detomidin ve butarfanolün sedasyon için enjeksiyonundan 10 dakika sonra ketamin anestezi amacı ile uygulandı. Uygulanan anesteziden 30 dakika sonunda atipamezol (AT) 30µg/kg IM uygulanarak kullanılan anaestezik ilaçların etkileri takip edildi. DB’ün sedatif etkisi enjeksiyonu takiben üç dakika sonra ve anestezik etki (ağrı uyaranlarına tepki kaybı) K enjeksiyonundan beş dakika sonra görüldü. Kalp atımı, vücut ısısı ve P amplitüt değerlerinde AT enjesinonu kadar önemli değişimler tespit edildi. Solunum sayısının aksine PR aralığı ve R amplitütleri anestezi sürecince azalma gösterdi. Parsiyel venöz oksijen basıncı (PO2) ve parsiyel venöz karbondioksit basıncı (PCO2) değerleri anestezi süresince azalış gösterdi. Hemoglobin (Hg), lökosit (WBC), eritrosit (RBC) ve hematokrit (Ht) değerlerini içeren hematolojik parametrelerde önemli değişim görülmedi. Sonuç olarak, BDK anestezi kombinasyonunun kardiyorespiratorik sistemi baskıladığı fakat koyunlar için yeterli derecede sedasyon ve anestezi sağladığı görüldü. AT’ün koyunlarda bu anestezi kombinasyonu için güvenli bir şekilde kullanılabileceği tespit edildi. 

Kaynakça

  • 1- Atalan G, Uzun M, Demirkan I, Yıldız S, Cenesiz M. Effect of medetomidine-butorphanol-ketamine anaesthesia and atipamezole on heart and respiratory rate and cloacal tempature of domestic pigeons. J Vet Med A Physiol Pathol Clin Med 2002; 49(6): 281-5. 2- Aantaa R. Alpha-2 adrenoceptor antagonists. Bailliere’s Cinical Anaesthesiology 2000; 14: 285-92. 3- Chittick E, Horne W, Wolfe B, Sladky K, Loomis M. Cadiopulmonary assessment of medetomidine, ketamine, and butorphanol anaesthesia in Captive Thomson’s Gazelles (Gazella Thomsoni). J Zoo Wildl Med 2001; 32(2): 168-75. 4- Dart CM. Advantages and disadvantage of using alpha-2 agonists in veterinary practice. Aust Vet J 1999; 77(11): 720-2. 5- DiMaioKnych HK, Covamubias V, Steffey EP. Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse. Veterinary Anaesthesia Analgesia 2012; 39(6): 574-83. 6- Galotos AD. Anaesthesia and Analgesia in sheep and goats. Vet Clin Food Anim 2001; 27:47-59. 7- Hall LW, Clerk KW. Anaesthesia in dog. Hall LW, Clerk KW eds. In: Veterinary Anaesthesia. Philadelphia: Bailliere Tindall,1991, pp. 51-347. 8- Hall LW, Clerk KW, Trim CM. Anaesthesia of sheep, goats and other herbivores.Hall LW, Clerk KW, Trim CM eds. In: Veterinary Anaesthesia. England: W.B. Saunders, 2000,pp. 341-66. 9- Hartsfield SM. Advantages and guidelines for using ketamine for induction of anaesthesia. Vet Clin Small Anim 1992; 22: 266-7. 10- Howard BW, Lagutchik MS, Januszkiewicz AJ, Martin DG. The cardiovascular response of sheep to tiletamine-zolazepam and butorphanol tartrate anaesthesia. Vet Surg 1990; 19(6): 461-7. 11- Kariman A, Sharifi D, Nowrouzian I. Evaluation of detomidine hydrochloride, diazepam and thiopental sodium combination on cardiovascular function and hemodynamics in sheep. Small Ruminant Research 1998; 29(1):43-9. 12- Kastner SBR. Alpha2 agonists in sheep: A review. Veterinary Anaesthesia and Analgesia 1998; 33(2): 79-96. 13- Kastner SBR, Ohlerth S, Pospischil A, Boller J, Huhtinen MK. Dexmedetomidine induced pulmonary alterations in sheep. Res Vet Sci 2007; 83(2): 217-26. 14- Khan MA, Ashraf M, Pervez K, Rashid HB, Mahmood AK, Chaudhry M. Comparative effects of detomidine and xylazine as sedative and analgesic agents in small ruminants. Pak Vet J 2004; 24(2), 16-20. 15- Laitinen OM. Clinical observation on medetomidine/ketamine anaesthesia in sheep and its reversal by atipemazole. J Assoc Vet Anaest 1990;17:17-19. 16- Lin HC, Wallace SS, Tyler JW, Robbins RL, Thurmon JC, Wolfe DF. Comparasion of tilatamine-zolazepam-ketamine and tiletamine-zolezapam-ketamine-xylazine anaesthesia in sheep. Aust Vet J 1994;71(8): 239-42. 17- Lin HC, Prohit RC, Powe TA. Anaesthesia in sheep with propofol or with xylazine-ketamine followed by Halothane. Veterinary Anesthesia and Analgesia 1997;26(3):247-52. 18- Mahmood BM, Mohammad FK. Antagonism of medetomidine sedation in goats by atipamezole and yohimbine. Turk J Vet Anim Sci 2008; 32: 429-32. 19- Mama KR. Anaesthesic management of Horse: Intravenous Anaesthesia. http://www.ivis.org/advances/Steffey_Anesthesia/mama_horse/chapter_frm.asp?LA=1, Acces of date; 16.01.2009. 20- Nolan A, Livingston A, Waterman A. The effects of alpha-2 adrenoceptoragonists on airway pressure in anesthetized sheep. J Vet Pharmacol Therap 1986; 9: 157-63. 21- O’hair KC, Dodd KT, Philips YY, Beattie RJ. Cardiopulmonary effects of nalbuphine Hydrochloride and butorphanol tartrate in sheep. Lab Anim Sci 1988; 38(1): 58-61. 22- Onmaz AC, Gunes V, Atalan G, Gelfert CC, Atalan G. Comparasion of arterial and venous blood gas values in sheep before and during isoflurane anaesthesia. Revue Med Vet 2009; 160: 356-61. 23- Ranheim B, Arnemo JM, Stuen S, Horsberg TE. Medetomidine and atipamezole in sheep: Disposition and clinical effects. J Vet Pharmacol Therap 2000; 23(6): 401-4. 24- Short CE. Effects of anticholinergic treatment on the cardiac and respiratory systems in dogs sedated with medetomidine. Vet Rec 1991; 129(14): 310-13. 25- Thurmon JC, Kumar A, Link EP. Evaluation of ketamine hydrochloride as an anaesthetic in sheep. J Am Vet Med Assoc 1973; 162: 293-97. 26- Verstegen J, Petcho A. Medetomidine-butorphanol-midozalam for anaesthesia in dogs and its reversal by atipamezole. Vet Rec 1993; 132(14): 353-7. 27- Waterman AE, Nolan A, Livingston A. Influence of idazoxan on the respiratory blood gas changes induced by alpha2-adrenoceptor agonist drugs in conscious sheep. Vet Rec 1987; 121 (5): 105-7. 28- Waterman AE, Livingston A, Amin A. Analgesic activity and respiratory effects of butorphanol in sheep. Res Vet Sci 1991; 51(1): 19-23.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Gültekin Atalan Bu kişi benim 0000-0002-2613-5638

Yayımlanma Tarihi 25 Mart 2019
Gönderilme Tarihi 20 Şubat 2018
Kabul Tarihi 26 Şubat 2018
Yayımlandığı Sayı Yıl 2019 Cilt: 16 Sayı: 1

Kaynak Göster

APA Atalan, G. (2019). Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 16(1), 1-7. https://doi.org/10.32707/ercivet.538035
AMA Atalan G. Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep. Erciyes Üniv Vet Fak Derg. Mart 2019;16(1):1-7. doi:10.32707/ercivet.538035
Chicago Atalan, Gültekin. “Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 16, sy. 1 (Mart 2019): 1-7. https://doi.org/10.32707/ercivet.538035.
EndNote Atalan G (01 Mart 2019) Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 16 1 1–7.
IEEE G. Atalan, “Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep”, Erciyes Üniv Vet Fak Derg, c. 16, sy. 1, ss. 1–7, 2019, doi: 10.32707/ercivet.538035.
ISNAD Atalan, Gültekin. “Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 16/1 (Mart 2019), 1-7. https://doi.org/10.32707/ercivet.538035.
JAMA Atalan G. Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep. Erciyes Üniv Vet Fak Derg. 2019;16:1–7.
MLA Atalan, Gültekin. “Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, c. 16, sy. 1, 2019, ss. 1-7, doi:10.32707/ercivet.538035.
Vancouver Atalan G. Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep. Erciyes Üniv Vet Fak Derg. 2019;16(1):1-7.