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Cytokines – major molecular messengers orchestrate between inflammation and cancer

Yıl 2018, Cilt: 4 Sayı: 3, 140 - 144, 04.07.2018
https://doi.org/10.18621/eurj.347542

Öz

Inflammation
is the defensive mechanism against physical or chemical or thermal or infectious agents.
Acute inflammation is a protective mechanism against any noxious stimuli by
various mediators such as cytokines, chemokines, enzymes, growth factors by
inflammatory cells. If the inflammation is aggrevated chronically, smouldering
inflammation results in release of inflammatory mediators such as cytokines,
chemokines, growth factors, proteolytic enzymes, from innate and adaptive
immune cells results in tumor initiation, tumor promotion and tumor
progression. Cytokines are intercellular molecular messengers between immune
cells and cancer cells, synthesized from immune cells and stromal cells
activate transcription factors bring about tumor progression by cell
proliferation, cell survival, angiogenesis, genomic instability, epithelial to
mesenchymal transition, invasion and metastasis. This article briefs about
the role of IL-1, TNF-α, IL-6, IL-8, IL-10, TGF-β, and IL-17 cytokines in
progression of cancer. 

Kaynakça

  • [1] Landskron G, De la Fuente M, Thuwajit P, Thuwajit C, Hermoso MA. Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res 2014;2014:149185.
  • [2] Amedei A, Prisco D, D' Elios MM. The use of cytokines and chemokines in the cancer immunotherapy. Recent Pat Anticancer Drug Discov 2013;8:126-42.
  • [3] Sadaf EZ. Role of inflammatory cytokines in inflammation and cancer. J Public Health Biological Sci 2013;2:173-82.
  • [4] Lee S, Margolin K. Cytokines in cancer immunotherapy. Cancers (Basel) 2011;3:3856-93.
  • [5] Anestakis D, Petanidis S, Kalyvas S, Nday CM, Tsave O, Kioseoglou E, et al. Mechanisms and applications of interleukins in cancer immunotherapy. Int J Mol Sci 2015;16:1691-710.
  • [6] Burkholder B, Huang RY, Burgess R, Luo S, Jones VS, Zhang W, et al. Tumor-induced perturbation of cytokines and immune cell networks. Biochim Biophys Acta 2014;1845:182-201.
  • [7] Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012;21:309-22.
  • [8] Paltridge JL, Belle L, Khew-Goodall Y. The secretome in cancer progression. Biochi Biophys Acta 2013;1834:2233-41.
  • [9] Zhong Z, Sanchez-Lopez E, Karin M. Autophagy, inflammation, and immunity: a Troika governing cancer and its treatment. Cell 2016;166:288-98.
  • [10] Haabeth OA, Bogen B, Corthay A. A model for cancer suppressive inflammation. Oncoimmunology 2012;1:1146-56.
  • [11] Pages F, Galon J, Dieu-Nosjean MC, Tartour E, Sautes-Fridman C, Fridman WH. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene 2010;29:1093-102.
  • [12] Schetter AJ, Heegaard NH, Harris CC. Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis 2010;31:37-49.
  • [13] Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumors: Impact on clinical outcome. Nat Rev Cancer 2012;12:298-396.
  • [14] Senovilla L, Vacchelli E, Galon J, Adjemian S, Eggermont A, Fridman WH, et al. Trial watch: Prognostic and predictive value of the immune infiltrate in cancer. Oncoimmunology 2012;1:1323-43.
  • [15] Shalapour S, Karin M. Immunity, inflammation, and cancer: an eternal fight between good and evil. J Clin Invest 2015;125:3347-55.
  • [16] Alvaliotis IL, Pateras IS, Papaioannou M, Glytsou C, Kontzoglou K, Johnson EO, et al. How do cytokines trigger genomic instability? J Biomed Biotechnol 2012;2012:536761.
  • [17] Vesely MD, Kershaw MH, Schreiber RD, Smith MJ. Natural innate and adaptive immunity to cancer. Annu Rev Immunol 2011;29:235-71.
  • [18] Meulmeester E, Ten Dijke P. The dynamic roles of TGF-β in cancer. J Pathol 2011;223:205-18.
  • [19] Shrihari TG, Vasudevan V, Manjunath V, Devaraju D. Potential co-relation between chronic periodontitis and cancer - an emerging concept. Gulf J Oncolog 2016;1:20-4.
  • [20] Korniluk A, Koper O, Kemona H, Dymicka-Piekarska V. From inflammation to cancer. Ir J Med Sci 2017;186:57-62.
  • [21] Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011;473:298-307.
  • [22] Tecchio C, Scapini P, Pizzolo G, Cassatella MA. On the cytokines produced by human neutrophils in tumors. Semin Cancer Biol 2013;23:159-70.
  • [23] Chai EZ, Siveen KS, Shanmugam MK, Arfuso F, Sethi G. Analysis of the intricate relationship between chronic inflammation and cancer. Biochem J 2015;468:1-15.
  • [24] Wilke CM, Kryczek I, Wei S, Zhao E, Wu K, Wang G, et al. Th17 cells in cancer; help or hindrance? Carcinogenesis 2011;32:643-9.
  • [25] Zhang L, Feng D, Yu LX, Tsung K, Norton JA. Preexisting antitumor immunity augments the antitumor effects of chemotherapy. Cancer Immunol Immunother 2013;62:1061-71.
  • [26] Chimal-Ramirez GK, Espinoza-Sanchez NA, Fuentes-Panama EM. Protumor activities of the immune response: insights in the mechanisms of immunological shift, oncotraining, and oncopromotion. J Oncol 2013;2013:835956.
  • [27] Marata M, Thanan R, Ma N, Kawanishi S. Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis. J Biomed Biotechnol 2012;2012:623019.
  • [28] Shrihari TG. Dual role of inflammatory mediators in cancer. Ecancermedicalscience 2017;11:721.
  • [29] Lippitz BE. Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol 2013;14:218-28.
  • [30] Diakowska D. Cytokines association with clinical and pathological changes in esophageal squamous cell carcinoma. Dis Markers 2013;35:883-93.
Yıl 2018, Cilt: 4 Sayı: 3, 140 - 144, 04.07.2018
https://doi.org/10.18621/eurj.347542

Öz

Kaynakça

  • [1] Landskron G, De la Fuente M, Thuwajit P, Thuwajit C, Hermoso MA. Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res 2014;2014:149185.
  • [2] Amedei A, Prisco D, D' Elios MM. The use of cytokines and chemokines in the cancer immunotherapy. Recent Pat Anticancer Drug Discov 2013;8:126-42.
  • [3] Sadaf EZ. Role of inflammatory cytokines in inflammation and cancer. J Public Health Biological Sci 2013;2:173-82.
  • [4] Lee S, Margolin K. Cytokines in cancer immunotherapy. Cancers (Basel) 2011;3:3856-93.
  • [5] Anestakis D, Petanidis S, Kalyvas S, Nday CM, Tsave O, Kioseoglou E, et al. Mechanisms and applications of interleukins in cancer immunotherapy. Int J Mol Sci 2015;16:1691-710.
  • [6] Burkholder B, Huang RY, Burgess R, Luo S, Jones VS, Zhang W, et al. Tumor-induced perturbation of cytokines and immune cell networks. Biochim Biophys Acta 2014;1845:182-201.
  • [7] Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012;21:309-22.
  • [8] Paltridge JL, Belle L, Khew-Goodall Y. The secretome in cancer progression. Biochi Biophys Acta 2013;1834:2233-41.
  • [9] Zhong Z, Sanchez-Lopez E, Karin M. Autophagy, inflammation, and immunity: a Troika governing cancer and its treatment. Cell 2016;166:288-98.
  • [10] Haabeth OA, Bogen B, Corthay A. A model for cancer suppressive inflammation. Oncoimmunology 2012;1:1146-56.
  • [11] Pages F, Galon J, Dieu-Nosjean MC, Tartour E, Sautes-Fridman C, Fridman WH. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene 2010;29:1093-102.
  • [12] Schetter AJ, Heegaard NH, Harris CC. Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis 2010;31:37-49.
  • [13] Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumors: Impact on clinical outcome. Nat Rev Cancer 2012;12:298-396.
  • [14] Senovilla L, Vacchelli E, Galon J, Adjemian S, Eggermont A, Fridman WH, et al. Trial watch: Prognostic and predictive value of the immune infiltrate in cancer. Oncoimmunology 2012;1:1323-43.
  • [15] Shalapour S, Karin M. Immunity, inflammation, and cancer: an eternal fight between good and evil. J Clin Invest 2015;125:3347-55.
  • [16] Alvaliotis IL, Pateras IS, Papaioannou M, Glytsou C, Kontzoglou K, Johnson EO, et al. How do cytokines trigger genomic instability? J Biomed Biotechnol 2012;2012:536761.
  • [17] Vesely MD, Kershaw MH, Schreiber RD, Smith MJ. Natural innate and adaptive immunity to cancer. Annu Rev Immunol 2011;29:235-71.
  • [18] Meulmeester E, Ten Dijke P. The dynamic roles of TGF-β in cancer. J Pathol 2011;223:205-18.
  • [19] Shrihari TG, Vasudevan V, Manjunath V, Devaraju D. Potential co-relation between chronic periodontitis and cancer - an emerging concept. Gulf J Oncolog 2016;1:20-4.
  • [20] Korniluk A, Koper O, Kemona H, Dymicka-Piekarska V. From inflammation to cancer. Ir J Med Sci 2017;186:57-62.
  • [21] Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011;473:298-307.
  • [22] Tecchio C, Scapini P, Pizzolo G, Cassatella MA. On the cytokines produced by human neutrophils in tumors. Semin Cancer Biol 2013;23:159-70.
  • [23] Chai EZ, Siveen KS, Shanmugam MK, Arfuso F, Sethi G. Analysis of the intricate relationship between chronic inflammation and cancer. Biochem J 2015;468:1-15.
  • [24] Wilke CM, Kryczek I, Wei S, Zhao E, Wu K, Wang G, et al. Th17 cells in cancer; help or hindrance? Carcinogenesis 2011;32:643-9.
  • [25] Zhang L, Feng D, Yu LX, Tsung K, Norton JA. Preexisting antitumor immunity augments the antitumor effects of chemotherapy. Cancer Immunol Immunother 2013;62:1061-71.
  • [26] Chimal-Ramirez GK, Espinoza-Sanchez NA, Fuentes-Panama EM. Protumor activities of the immune response: insights in the mechanisms of immunological shift, oncotraining, and oncopromotion. J Oncol 2013;2013:835956.
  • [27] Marata M, Thanan R, Ma N, Kawanishi S. Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis. J Biomed Biotechnol 2012;2012:623019.
  • [28] Shrihari TG. Dual role of inflammatory mediators in cancer. Ecancermedicalscience 2017;11:721.
  • [29] Lippitz BE. Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol 2013;14:218-28.
  • [30] Diakowska D. Cytokines association with clinical and pathological changes in esophageal squamous cell carcinoma. Dis Markers 2013;35:883-93.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Reviews
Yazarlar

Shrihari T.g

Yayımlanma Tarihi 4 Temmuz 2018
Gönderilme Tarihi 28 Ekim 2017
Kabul Tarihi 19 Şubat 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 4 Sayı: 3

Kaynak Göster

AMA T.g S. Cytokines – major molecular messengers orchestrate between inflammation and cancer. Eur Res J. Temmuz 2018;4(3):140-144. doi:10.18621/eurj.347542

e-ISSN: 2149-3189 


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