Year 2019, Volume 5, Issue 1, Pages 14 - 19 2019-01-04

The relationship between atrial natriuretic peptide and microvascular complications of diabetes

Pınar Karakaya [1] , Bahar Özdemir [2] , Meral Mert [3] , Hakan Koçoğlu [4] , Abdulbaki Kumbasar [5]

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Objective: In this study, we aimed to determine the relationship between the atrial natriuretic peptide and microvascular complications of diabetes.

Methods: Sixty patients with type 2 diabetes mellitus were enrolled into the study. Patients with a chronic disease other than diabetes mellitus were excluded from the study. The body-mass index, waist circumference, and hip circumference were measured and blood samples for routine biochemical tests were taken after at least 12 hours fasting. The microvascular complications of the patients were evaluated.

Results: Thirty-two of the patients had microvascular complications whereas 28 of them did not. Age, body mass index, waist and hip circumference, and atrial natriuretic peptide levels were significantly higher in the group with microvascular complications than those without complications. There was no significant difference in parameters like; waist-hip ratio, blood glucose, HbA1c, fasting insulin, fasting HOMA, sodium, potassium, magnesium, calcium and lipid levels between the two groups. When the relationship between atrial natriuretic peptide and obesity, retinopathy, neuropathy, nephropathy, duration of diabetes, HbA1c, and sex are evaluated separately, the only significant parameters related to atrial natriuretic peptide were the body-mass index, waist circumference, hip circumference measurements, and neuropathy.

Conclusions: Positive correlations between serum atrial natriuretic peptide levels and body-mass index, waist circumference, and hip circumference measurements were determined. Also, serum atrial natriuretic peptide levels were significantly higher in patients with obesity or neuropathy than those without obesity or neuropathy. 

Atrial natriuretic peptide, diabetes mellitus, microvascular complications
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Orcid: 0000-0003-3337-4423
Author: Pınar Karakaya
Institution: Department of Endocrinology and Metabolic Diseases, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
Country: Turkey


Orcid: 0000-0003-4111-2941
Author: Bahar Özdemir
Institution: Department of Internal Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
Country: Turkey


Orcid: 0000-0003-3431-0915
Author: Meral Mert
Institution: Department of Endocrinology and Metabolic Diseases, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
Country: Turkey


Orcid: 0000-0002-9208-2693
Author: Hakan Koçoğlu (Primary Author)
Institution: Department of Internal Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
Country: Turkey


Orcid: 0000-0001-7466-9434
Author: Abdulbaki Kumbasar
Institution: Department of Internal Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
Country: Turkey


Dates

Publication Date: January 4, 2019

EndNote %0 The European Research Journal The relationship between atrial natriuretic peptide and microvascular complications of diabetes %A Pınar Karakaya , Bahar Özdemir , Meral Mert , Hakan Koçoğlu , Abdulbaki Kumbasar %T The relationship between atrial natriuretic peptide and microvascular complications of diabetes %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 1 %R doi: 10.18621/eurj.410990 %U 10.18621/eurj.410990