Year 2019, Volume 5, Issue 2, Pages 413 - 417 2019-03-04

An interesting co-existence of celiac disease and idiopathic pulmonary hemosiderosis: Lane Hamilton syndrome

Gökçe Pınar Reis [1] , Ali Fettah [2] , Burcu Volkan [3] , Sevilay Özmen [4] , İlknur Çalık [5] , Alev Cansu Certel [6]

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Idiopathic pulmonary hemosiderosis is characterized by hemoptysis resulting from recurring alveolar hemorrhage attacks, iron deficiency anemia, and parenchymal infiltrations as seen on chest radiographs. The clinical course may consist of silent and asymptomatic attacks, or it may sometimes exhibit a fulminant course with rapidly developing anemia and hypoxemia. Celiac disease is an autoimmune enteropathy triggered by the consumption of gluten-containing foods in genetically predisposed individuals. Co-existence of idiopathic pulmonary hemosiderosis and celiac disease is defined as Lane-Hamilton syndrome. We describe a case of Lane-Hamilton syndrome with growth and developmental delay; complete remission of pulmonary symptoms was achieved with a gluten-free diet. 

Idiopathic pulmonary hemosiderosis, celiac disease, anemia, gluten-free diet
  • [1] Nishino M, Patrick James L, Connors Jean M. Lane-Hamilton Syndrome. Radiology 2010;254:985-8.
  • [2] Loule S, Russell LA, Richeson RB, Carroll E. Circulating immune complexes with pulmonary hemorrhage during pregnancy in idiopathic pulmonary hemosiderosis. Chest 1993;104:1907-9.
  • [3] Leaker B, Cambridge G, du Bois RM, Neild GH. Idiopathic pulmonary haemosiderosis: a form of microscopic polyarteritis? Thorax 1992;47:988-90.
  • [4] Khemiri M, Ouederni M, Khaldi M, Barsaoui S. Screening for celiac disease in idiopathic pulmonary hemosiderosis. Gastroenterol Clin Biol 2008; 32:745-8.
  • [5] Ferrari GF, Fioretta JR, Alves AFR, Brandao GS. Idiopathic pulmonary haemosiderosis: case report. J Pediatr 2006;76:149-52.
  • [6] Ioachimescu O.C, Sieber S, Kotch A. Idiopathic pulmonary hemosiderosis revisited. Eur Respir J 2004;24:162-70.
  • [7] Margon P.G, Tuner Warwick M. Pulmonary hemosiderosis and pulmonary haemorrhage. Br Dis Chest 1981;75:225-42.
  • [8] Ertekin V, Selimoglu MA, Gursan N, Ozkan B. Idiopathic pulmonary hemosiderozis in children with celiac disease. Respir Med 2006;100:568-9.
  • [9] Le Clainche L, Le Bourgeois M, Fauroux B, Forenza N, Dommergues JP, Desbois JC, et al. Long-term outcome of idiopathic pulmonary hemosiderosis in children. Medicine (Baltimore) 2000;79:318-26.
  • [10] Corrin B, Jagusch M, Dewar A, Tungekar MF, Davies DR, Warner JO, et al. Fine structural changes in idiopathic pulmonary haemosiderosis. J Pathol 1987;153:249-56.
  • [11] Milman N, Pedersen FM. Idiopathic pulmonary hemosiderozis. Epidemiology, pathogenic aspects and diagnosis. Respir Med 1998;92:902-7.
  • [12] Custer G, Balcerzak S, Rinehart J. Human macrophage hemoglobin-iron metabolism in vitro. Am J Hematol 1982;13:23-36.
  • [13] Erdil A, Ateş Y. Gluten enteropatisinde son gelişmeler. Güncel Gastroenteroloji 2005;9:18-28.
  • [14] Fesus L, Piacentini M. Transglutaminase 2: an enigmatic enzyme with diverse functions. Trends Biochem Sci 2002;27:534-9.
  • [15] Perelman S, Dupuy C, Bourrillon A. [The associationof pulmonary hemosiderosis and celiac disease. Apropo of a new case in a child]. Ann Pediatr 1992;39:185-8. [Article in French]
  • [16] Bakan DN, Kanmaz D, Özkan G, Uçar E, Taşçı C, Karslıoğlu Y, et al. [Idiopathic pulmonary hemosiderosis]. Tur Toraks Der 2008;9:124-6. [Article in Turkish]
Primary Language en
Subjects Health Care Sciences and Services
Journal Section Case Reports
Authors

Orcid: 0000-0002-0064-2711
Author: Gökçe Pınar Reis
Institution: Department of Pediatric Hematology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Country: Turkey


Orcid: 0000-0003-4109-2143
Author: Ali Fettah
Institution: Department of Pediatric Hematology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Country: Turkey


Orcid: 0000-0002-0528-3826
Author: Burcu Volkan (Primary Author)
Institution: Department of Pediatric Gastroenterology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Country: Turkey


Orcid: 0000-0002-1973-6101
Author: Sevilay Özmen
Institution: Department of Pathology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Country: Turkey


Orcid: 0000-0003-2160-7453
Author: İlknur Çalık
Institution: Department of Pathology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Country: Turkey


Orcid: 0000-0002-1096-3455
Author: Alev Cansu Certel
Institution: Department of Pediatrics, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Country: Turkey


Dates

Publication Date: March 4, 2019

EndNote %0 The European Research Journal An interesting co-existence of celiac disease and idiopathic pulmonary hemosiderosis: Lane Hamilton syndrome %A Gökçe Pınar Reis , Ali Fettah , Burcu Volkan , Sevilay Özmen , İlknur Çalık , Alev Cansu Certel %T An interesting co-existence of celiac disease and idiopathic pulmonary hemosiderosis: Lane Hamilton syndrome %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 2 %R doi: 10.18621/eurj.406178 %U 10.18621/eurj.406178