Araştırma Makalesi
BibTex RIS Kaynak Göster

The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty

Yıl 2019, Cilt: 9 Sayı: 1, 9 - 14, 27.03.2019
https://doi.org/10.16899/gopctd.535602

Öz

Introduction:
Most important factors in retinopathy of prematurity (ROP) are prematurity and
oxygen toxicity although blood transfusions, insulin like growth factor-1 (
IGF-1), insulin like growth factor binding protein 3 (IGFBP-3) and vascular
endothelial growth factor (VEGF) also have important roles.



The
objectives of this study were, to measure IGF-1 and IGFBP-3 levels in preterm
newborns before and after blood transfusion and assess if the effect of
transfusion in development of ROP is via these mediators, and to investigate
whether IGF-1 and IGFBP-3 levels measured at 32 and 33 gestational age (GA)
were different in preterm newborns with and without ROP.



Material
and Methods: Preterm newborns with gestational age ≤34 weeks were included and
blood samples were obtained before and after red blood cell (RBC) transfusion.



Results:
Thirty newborns were included, 17 of whom had ROP ( stage 1: n=11, stage 2:
n=5, stage 3: n=1). IGF-1 and IGFBP-3 levels did not change after RBC
tranfusion. Excluding the patient with stage 3 ROP all ROP patients were
referred as mild ROP. No difference was observed between IGF-1 and IGFBP-3
levels of the patients with and without mild ROP. Patients with mild ROP had
significantly more number of transfusions.



Conclusions:
Erythrocyte transfusion increased the frequency of ROP, whereas IGFBP-3 and
IGF-1 were not associated of ROP.

Kaynakça

  • REFERENCES:1- Good WV, Hardy RJ, Dobson V, et al. Early treatment for retinopathy of prematurity cooperative group. The incidence and course of retinopathy of prematurity:findings fromthe earlytreatment of retinopathy of prematurity study. Pediatrics 2005;116(1):15-23.
  • 2- Mathew MR, Fern AI, Hill R. Retinopathy of prematurity: Are we screening too many babies? Eye 2002;16(5):538-542.
  • 3- Bas AY, Demirel N, Koc E, Ulubas Isik D, Hirfanoglu İM, Tunc T; TR-ROP Study Group. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units. prospective, multicentre study in 69 neonatal intensive care units. Br J Ophthalmol. 2018 Mar 8.
  • 4- Smolkin T, Steinberg M, Sujov P,et al. Late postnatal systemic steroids predispose to retinopathy of prematurity in very low birth weight infants:a comparative study. Acta Paediatrica 2008;97(3):322-326.
  • 5- Bizzarro MJ, Hussein N, Jonsson B, et al. Genetic susceptibility in retinopathy of prematurity. Pediatrics 2006;118(5):1858-1863.
  • 6- Coleman R, Beharry KD, Brock RS, et al. Effects of brief , clustered versus dispersed hypoxic episodes on systemic and ocular growth factors in a rat model of oxygen induced retinopathy. Pediatr Res 2008;64(1):50-55.
  • 7- Zhang S, Zhou R, Li B, et al. Caffeine preferentially protects against oxygen-induced retinopathy. FASEB J. 2017 Aug;31(8):3334-3348.
  • 8- Hellstrom A, Perruzzi C, Ju M, Engstrom E . Low IGF-1 suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity. PNAS 2001; 98(10):5804-5808.
  • 9- Chen J, Smith LE. Retinopathy of prematurity. Angiogenesis 2007;10(2):133-140.
  • 10- Smith LE. Pathogenesis of retinopathy of prematurity Growth Hormone and IGF. Growth Horm IGF Res 2004;14:S140-S144.11- Smith LE. Pathogenesis of retinopathy of prematurity. Semin Perinatol 2003;8(6):469-473.
  • 12- Yeung MY. Somatotropic axis derangement as an underlying factor in the genesis of retinopathy of prematurity. Acta Paediatrica 2006;95(11):1334-1340.
  • 13- Dani C, Reali MF, Bertini G,et al. The role of blood transfusions and iron intake on retinopathy of prematurity. Earl Hum Dev 2001;62(1):57-63.
  • 14- Hesse L, Eberl W, Schlaud M, et al. Blood transfusion iron load and retinopathy of prematurity. Eur J Pediatr 1997;156(6):465-470.
  • 15- Azami M, Jaafari Z, Rahmati S, Farahani AD, Badfar G. Prevalence and risk factors of retinopathy of prematurity in Iran: a systematic review and meta-analysis. BMC Ophthalmol. 2018 Apr 2;18(1):83.
  • 16- Hübler A, Knote K, Kauf E, et al. Does insulin-like growth factor 1 contribute in red blood cell transfusions to the pathogenesis of retinopathy of prematurity during retinal neovascularization? Biol Neonate 2006;89(2):92-98.
  • 17- Lofqvist C, Chen J, Connor KM, et al. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular growth. PNAS 2007;104(25): 10589-10594.
  • 18- Rajah R, Valenitis B, Cohen P. Insulin-like growth factor binding protein-3 induces apoptosis and mediates the effects of transforming growth factor beta 1 on programmed cell death through a p53 and IGF independent mechanism. J Biol Chem 1997; 272(18):12181-12188.
  • 19- American Academy of Pediatrics,American Academy of Opthalmology, American Association for Pediatric Opthalmology and Strabismus. Screening examination for premature infants for retinopathy of prematurity. Policy Statement. Pediatrics 2013 Jan;131(1):189-95.
  • 20- International committee for the classification of retinopathy of prematurity. The international classification of retinopathy of prematurity revisited. Arch Opthalmol 2005;123(7):991-999.
  • 21- Hellstrom A, Engstrom E, Hard AL, et al. Postnatal insulin-like growth factor deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics 2003;112(5):1016-1020.
  • 22- Lofqvist C, Enstrom E, Sigudsson J, et al. Postnatal head growth deficit among premature infants parallels retinopathy of prematurity and insulin-like growth factor deficit. Pediatrics 2006;117(6):1930-1938.
  • 23- Modanlou HD, Gharraee Z, Hasan J et al. Ontogeny of VEGF, IGF-1, and GH in neonatal rat serum vitreous fluid, and retina from birth to weaning. Invest Opthtalmol Vis Sci 2006;47(2):738-744
  • 24- Hellstrom A, Carlsson B, Niklasson A, et al. IGF-1 is critical for normal vascularization of the human retina. J Clin Endocrinol Metab 2002 ; 87(7):3413-3416.
  • 25- Hansen-Pupp IH, Hellstrom-Westas L, Cilio CM, et al . Inflammation at birth and the insulin-like growth factor system in very preterm infants. Acta Paediatrica 2007;96(6): 830-836.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Orjinal Çalışma
Yazarlar

Davut Bozkaya 0000-0001-5548-7387

Ebru Ergenekon Bu kişi benim

Aysegul Yucel Bu kişi benim

Sengul Ozdek Bu kişi benim

İbrahim Hirfanoglu Bu kişi benim

Ozden Turan

Canan Turkyilmaz Bu kişi benim

Esra Onal Bu kişi benim

Esin Koc

Yıldız Atalay Bu kişi benim

Yayımlanma Tarihi 27 Mart 2019
Kabul Tarihi 12 Mart 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 9 Sayı: 1

Kaynak Göster

APA Bozkaya, D., Ergenekon, E., Yucel, A., Ozdek, S., vd. (2019). The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. Çağdaş Tıp Dergisi, 9(1), 9-14. https://doi.org/10.16899/gopctd.535602
AMA Bozkaya D, Ergenekon E, Yucel A, Ozdek S, Hirfanoglu İ, Turan O, Turkyilmaz C, Onal E, Koc E, Atalay Y. The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. J Contemp Med. Mart 2019;9(1):9-14. doi:10.16899/gopctd.535602
Chicago Bozkaya, Davut, Ebru Ergenekon, Aysegul Yucel, Sengul Ozdek, İbrahim Hirfanoglu, Ozden Turan, Canan Turkyilmaz, Esra Onal, Esin Koc, ve Yıldız Atalay. “The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty”. Çağdaş Tıp Dergisi 9, sy. 1 (Mart 2019): 9-14. https://doi.org/10.16899/gopctd.535602.
EndNote Bozkaya D, Ergenekon E, Yucel A, Ozdek S, Hirfanoglu İ, Turan O, Turkyilmaz C, Onal E, Koc E, Atalay Y (01 Mart 2019) The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. Çağdaş Tıp Dergisi 9 1 9–14.
IEEE D. Bozkaya, “The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty”, J Contemp Med, c. 9, sy. 1, ss. 9–14, 2019, doi: 10.16899/gopctd.535602.
ISNAD Bozkaya, Davut vd. “The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty”. Çağdaş Tıp Dergisi 9/1 (Mart 2019), 9-14. https://doi.org/10.16899/gopctd.535602.
JAMA Bozkaya D, Ergenekon E, Yucel A, Ozdek S, Hirfanoglu İ, Turan O, Turkyilmaz C, Onal E, Koc E, Atalay Y. The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. J Contemp Med. 2019;9:9–14.
MLA Bozkaya, Davut vd. “The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty”. Çağdaş Tıp Dergisi, c. 9, sy. 1, 2019, ss. 9-14, doi:10.16899/gopctd.535602.
Vancouver Bozkaya D, Ergenekon E, Yucel A, Ozdek S, Hirfanoglu İ, Turan O, Turkyilmaz C, Onal E, Koc E, Atalay Y. The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. J Contemp Med. 2019;9(1):9-14.