Year 2019, Volume 9, Issue 1, Pages 9 - 14 2019-03-27

The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty

Davut Bozkaya [1] , Ebru Ergenekon [2] , Aysegul Yucel [3] , Sengul Ozdek [4] , İbrahim Hirfanoglu [5] , Ozden Turan [6] , Canan Turkyilmaz [7] , Esra Onal [8] , Esin Koc [9] , Yıldız Atalay [10]

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Introduction: Most important factors in retinopathy of prematurity (ROP) are prematurity and oxygen toxicity although blood transfusions, insulin like growth factor-1 ( IGF-1), insulin like growth factor binding protein 3 (IGFBP-3) and vascular endothelial growth factor (VEGF) also have important roles.

The objectives of this study were, to measure IGF-1 and IGFBP-3 levels in preterm newborns before and after blood transfusion and assess if the effect of transfusion in development of ROP is via these mediators, and to investigate whether IGF-1 and IGFBP-3 levels measured at 32 and 33 gestational age (GA) were different in preterm newborns with and without ROP.

Material and Methods: Preterm newborns with gestational age ≤34 weeks were included and blood samples were obtained before and after red blood cell (RBC) transfusion.

Results: Thirty newborns were included, 17 of whom had ROP ( stage 1: n=11, stage 2: n=5, stage 3: n=1). IGF-1 and IGFBP-3 levels did not change after RBC tranfusion. Excluding the patient with stage 3 ROP all ROP patients were referred as mild ROP. No difference was observed between IGF-1 and IGFBP-3 levels of the patients with and without mild ROP. Patients with mild ROP had significantly more number of transfusions.

Conclusions: Erythrocyte transfusion increased the frequency of ROP, whereas IGFBP-3 and IGF-1 were not associated of ROP.

Retinopathy of prematurity, IGF-1, IGFBP-3
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Research
Authors

Orcid: 0000-0001-5548-7387
Author: Davut Bozkaya (Primary Author)
Institution: Gazı University
Country: Turkey


Author: Ebru Ergenekon

Author: Aysegul Yucel

Author: Sengul Ozdek

Author: İbrahim Hirfanoglu

Author: Ozden Turan

Author: Canan Turkyilmaz

Author: Esra Onal

Author: Esin Koc

Author: Yıldız Atalay

Dates

Publication Date: March 27, 2019

Bibtex @research article { gopctd535602, journal = {Çağdaş Tıp Dergisi}, issn = {}, eissn = {2146-6009}, address = {Rabia YILMAZ}, year = {2019}, volume = {9}, pages = {9 - 14}, doi = {10.16899/gopctd.535602}, title = {The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty}, key = {cite}, author = {Bozkaya, Davut and Ergenekon, Ebru and Yucel, Aysegul and Ozdek, Sengul and Hirfanoglu, İbrahim and Turan, Ozden and Turkyilmaz, Canan and Onal, Esra and Koc, Esin and Atalay, Yıldız} }
APA Bozkaya, D , Ergenekon, E , Yucel, A , Ozdek, S , Hirfanoglu, İ , Turan, O , Turkyilmaz, C , Onal, E , Koc, E , Atalay, Y . (2019). The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. Çağdaş Tıp Dergisi, 9 (1), 9-14. DOI: 10.16899/gopctd.535602
MLA Bozkaya, D , Ergenekon, E , Yucel, A , Ozdek, S , Hirfanoglu, İ , Turan, O , Turkyilmaz, C , Onal, E , Koc, E , Atalay, Y . "The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty". Çağdaş Tıp Dergisi 9 (2019): 9-14 <http://dergipark.org.tr/gopctd/issue/44052/535602>
Chicago Bozkaya, D , Ergenekon, E , Yucel, A , Ozdek, S , Hirfanoglu, İ , Turan, O , Turkyilmaz, C , Onal, E , Koc, E , Atalay, Y . "The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty". Çağdaş Tıp Dergisi 9 (2019): 9-14
RIS TY - JOUR T1 - The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty AU - Davut Bozkaya , Ebru Ergenekon , Aysegul Yucel , Sengul Ozdek , İbrahim Hirfanoglu , Ozden Turan , Canan Turkyilmaz , Esra Onal , Esin Koc , Yıldız Atalay Y1 - 2019 PY - 2019 N1 - doi: 10.16899/gopctd.535602 DO - 10.16899/gopctd.535602 T2 - Çağdaş Tıp Dergisi JF - Journal JO - JOR SP - 9 EP - 14 VL - 9 IS - 1 SN - -2146-6009 M3 - doi: 10.16899/gopctd.535602 UR - https://doi.org/10.16899/gopctd.535602 Y2 - 2019 ER -
EndNote %0 Çağdaş Tıp Dergisi The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty %A Davut Bozkaya , Ebru Ergenekon , Aysegul Yucel , Sengul Ozdek , İbrahim Hirfanoglu , Ozden Turan , Canan Turkyilmaz , Esra Onal , Esin Koc , Yıldız Atalay %T The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty %D 2019 %J Çağdaş Tıp Dergisi %P -2146-6009 %V 9 %N 1 %R doi: 10.16899/gopctd.535602 %U 10.16899/gopctd.535602
ISNAD Bozkaya, Davut , Ergenekon, Ebru , Yucel, Aysegul , Ozdek, Sengul , Hirfanoglu, İbrahim , Turan, Ozden , Turkyilmaz, Canan , Onal, Esra , Koc, Esin , Atalay, Yıldız . "The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty". Çağdaş Tıp Dergisi 9 / 1 (March 2019): 9-14. https://doi.org/10.16899/gopctd.535602
AMA Bozkaya D , Ergenekon E , Yucel A , Ozdek S , Hirfanoglu İ , Turan O , Turkyilmaz C , Onal E , Koc E , Atalay Y . The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. J Contemp Med. 2019; 9(1): 9-14.
Vancouver Bozkaya D , Ergenekon E , Yucel A , Ozdek S , Hirfanoglu İ , Turan O , Turkyilmaz C , Onal E , Koc E , Atalay Y . The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty. Çağdaş Tıp Dergisi. 2019; 9(1): 14-9.