Acetaminophen (Paracetamol) ve Gemfibrozil’in Farklı Buğday Varyetelerinin Mineral Alımı ve H2O2 İçeriği Üzerine Etkileri

Yıl 2019, Cilt: 9 Sayı: 2, 239 - 246, 15.04.2019

Etem Osma Nuray Güloğlu Eda Türkoğlu Müjgen Elveren

https://doi.org/10.17714/gumusfenbil.347865

Öz

Bu çalışma
ile Tıbbi İlaç ve Kişisel Bakım Ürünleri (PPCPs)’nin Ahmetağa, Cemre ve
Michelangelo buğday varyeteleri üzerindeki etkisi araştırılmıştır. Araştırmada
günlük hayatta sıklıkla tüketilen acetaminophen ve gemfibrozil olmak üzere iki
farklı tıbbi ilaç etken maddesi kullanılmıştır. Çalışma için ekim yapılacak
toprağa, 50, 100 ve 250 mg olacak şekilde acetaminophen ve gemfibrozil
karıştırılmıştır. İlaç etken maddesi ile karıştırılmış 650 g toprağın üzerine
her bir varyeteden 7 g buğday tohumu ekilmiş, bunun üzeri ise 100 g toprak ile
kaplanmıştır. Tarla kapasitesine uygun olarak buğdaylar belirli aralıklarla
sulanarak, 15 gün yetiştirildikten sonra hasat edilmiştir. Hasat edilen
örneklere ekstraksiyon işlemi yapıldıktan sonra, örneklerde H₂O₂
içeriği belirlenmiştir. Ayrıca, buğday örnekleri ön işlemlerden geçirildikten
sonra mineral element konsantrasyonları ICP-OES’te analiz edilmiştir. Kontrol
örnekleri ile test örnekleri arasındaki ilişki %95 güven aralığında,
istatistiksel olarak ANOVA testi ile değerlendirilmiş, anlamlı farklılıklar
tespit edilmiştir. Çalışmada, acetaminophen ve gemfibrozil uygulanan örneklerde
konsantrasyon artışına bağlı olarak kontrol grubu ile kıyaslandığında
buğdayların mineral element alımında azalma gözlenirken, H₂O₂
içeriğinde artış olduğu belirlenmiştir. 

Anahtar Kelimeler

Acetaminophen, Buğday, Gemfibrozil, ICP-OES, Mineral element

Effects of Acetaminophen (Paracetamol) and Gemfibrozil on Mineral Uptake and H2O2 Content of Different Wheat Varieties

Öz

This study investigated the effects of Pharmaceuticals and
Personal Care Products (PPCPs) on wheat varieties of Ahmetağa, Cemre and
Michelangelo. Two different active pharmaceuticals substances acetaminophen and
gemfibrozil, which are frequently consumed in daily life, were used in the
study. For study, acetaminophen and gemfibrozil were mixed with soil as
follows: 50, 100, and 250 mg. 7 g of wheat seeds were planted from each
varieties on each 650 gr of soil that mixed with the pharmaceuticals substance, then covered with 100 gr of soil.
The wheat was irrigated at certain intervals in accordance with the field
capacity and harvested after 15 days. After extracting the harvested wheats,
the content of H₂O₂ in the samples were determined.
Moreover, wheat samples were analyzed by ICP-OES for mineral element
concentrations after pre-treatment. The relationship between control samples and
test samples was evaluated statistically at 95% confidence interval, and
significant differences were determined. In the study, it was determined that
there was an increase in the H₂O₂ content in parallel
with a decrease in mineral element uptake of wheat samples treated with
increase amount of acetaminophen and gemfibrozil when compared to the control
group.

Anahtar Kelimeler

Acetaminophen, Gemfibrozil, ICP-OES, Mineral element, Wheat

Kaynakça

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