Year 2016, Volume 1, Issue 1, Pages 1 - 7 2016-08-15

Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni

Yasemin Altuner Torun [1] , Ayşe Betül Ergül [2] , Meriban Karadoğan [3] , Fatma Türkan Mutlu [4]

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Sitomegalovirüs (CMV) enfeksiyonu immün sistemi normal olanlar bireylerde genellikle asemptomatik seyretmekle birlikte nadiren ciddi klinik tablolar tanımlanmıştır. Sağlıklı erişkinlerde CMV enfeksiyonu sonrası ciddi trombositopeni gelişen vakalar bildirilmiş olmasına rağmen çocuklarda bildirilen vaka sayısı azdır.  CMV enfeksiyonuna bağlı trombositopenide tedavide ilk seçenek steroidlerdir, bununla birlikte dirençli vakalarda intravenöz immunglobulin (İVİG) tedavisi oldukça etkili olmaktadır. Biz bu yazıda CMV enfeksiyonu sonrasında   trombositopeni gelişen ve  İVİG tedavisine dramatik yanıt alınan  bir çocuk hastayı sunduk.


Abstract

Cytomegalovirus (CMV) infection is generally asymptomatic in the immunocompetent  hosts and rarely defined as a severe clinical situation . However there have been several case reports of trombocytopenia after CMV infections in adults,  there are few reports about pediatric cases. The first choice in trombocytopenia related with CMV infections is streroids,  in refractory cases  intravenous immunoglobulin (IVIG) therapy is very effective. In this article  we describe a pediatric patient  who has trombocytopenia after CMV infection and be dramatically treated by IVIG therapy.

sitomegalovirüs, trombositopeni, intravenöz immunglobulin
  • 10. Yaari S, Koslowsky B, Wolf D, Chajek-Shaul T, Hershcovici T. CMV-related thrombocytopenia treated with foscarnet: a case series and review of the literature. Platelets 2010;21:490-5.
  • 9. Eisenberg MJ, Kaplan B. Cytomegalovirus-induced thrombocytopenia in an immunocompetent adult. West J Med 1993;158:525-6.
  • 8. Wu Z, Zhou J, Wei X, Wang X, Li Y, Peng B, Niu T. The role of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in immune thrombocytopenia. Hematology 2013;18:295-9.
  • 7. Europea Sugioka T, Kubota Y, Wakayama K, Kimura S. Severe steroid-resistant thrombocytopenia secondary to cytomegalovirus infection in an immunocompetent adult. Intern Med 2012;51:1747-50.
  • 6. Ichiche M, Fontaine C, Lacor P. Severe thrombocytopenia secondary to cytomegalovirus infection in an immunocompetent adult. Eur J Intern Med 2003;14:56-59.
  • 5. Rafailidis PI, Mourtzoukou EG, Varbobitis IC, Falagas ME. Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review. Virol J 2008;5:47.
  • 4. Schleiss MR. Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection. Clin Dev Immunol 2013;2013:501801.
  • 3. Sakata H, Ikegami K, Nagaya K, Shirai M, Maruyama S. Thrombocytopenia caused by acquired cytomegalovirus infection in children. Pediatr Int 1999;41:113-4.
  • 2. Taylor GH. Cytomegalovirus. Am Fam Physician 2003;67:519-24.
  • 1. Liberekacdf A, Rytlewskabe M, Szlagatys-Sidorkiewiczbc A, Bakoab et al. Cytomegalovirus disease in neonates and infants clinical presentation, diagnostic and therapeuticproblems – own experience Med Sci Monit 2002;8:CR815-20.
Subjects Health Care Sciences and Services
Journal Section Makale
Authors

Author: Yasemin Altuner Torun
Country: Turkey


Author: Ayşe Betül Ergül

Author: Meriban Karadoğan

Author: Fatma Türkan Mutlu

Dates

Publication Date: August 15, 2016

Bibtex @case report { jamer180800, journal = {Journal of Anatolian Medical Research}, issn = {}, eissn = {2587-1153}, address = {Kayseri EAH}, year = {2016}, volume = {1}, pages = {1 - 7}, doi = {}, title = {Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni}, key = {cite}, author = {Altuner Torun, Yasemin and Ergül, Ayşe Betül and Karadoğan, Meriban and Mutlu, Fatma Türkan} }
APA Altuner Torun, Y , Ergül, A , Karadoğan, M , Mutlu, F . (2016). Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni. Journal of Anatolian Medical Research, 1 (1), 1-7. Retrieved from http://dergipark.org.tr/jamer/issue/23664/180800
MLA Altuner Torun, Y , Ergül, A , Karadoğan, M , Mutlu, F . "Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni". Journal of Anatolian Medical Research 1 (2016): 1-7 <http://dergipark.org.tr/jamer/issue/23664/180800>
Chicago Altuner Torun, Y , Ergül, A , Karadoğan, M , Mutlu, F . "Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni". Journal of Anatolian Medical Research 1 (2016): 1-7
RIS TY - JOUR T1 - Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni AU - Yasemin Altuner Torun , Ayşe Betül Ergül , Meriban Karadoğan , Fatma Türkan Mutlu Y1 - 2016 PY - 2016 N1 - DO - T2 - Journal of Anatolian Medical Research JF - Journal JO - JOR SP - 1 EP - 7 VL - 1 IS - 1 SN - -2587-1153 M3 - UR - Y2 - 2019 ER -
EndNote %0 Journal of Anatolian Medical Research Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni %A Yasemin Altuner Torun , Ayşe Betül Ergül , Meriban Karadoğan , Fatma Türkan Mutlu %T Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni %D 2016 %J Journal of Anatolian Medical Research %P -2587-1153 %V 1 %N 1 %R %U
ISNAD Altuner Torun, Yasemin , Ergül, Ayşe Betül , Karadoğan, Meriban , Mutlu, Fatma Türkan . "Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni". Journal of Anatolian Medical Research 1 / 1 (August 2016): 1-7.
AMA Altuner Torun Y , Ergül A , Karadoğan M , Mutlu F . Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni. Journal of Anatolian Medical Research. 2016; 1(1): 1-7.
Vancouver Altuner Torun Y , Ergül A , Karadoğan M , Mutlu F . Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni. Journal of Anatolian Medical Research. 2016; 1(1): 7-1.