In Vitro Evaluation of Green and Red Propolis Extracts Against Candida spp

Yıl 2018, Cilt: 1 Sayı: 3 - 2nd Propolis Conference Special Issue, 41 - 41, 08.12.2018

M. D. Freıtas G. A. Lopes N. A Olıveıra B. M. Almeıda S. R. L. Abreu R. C. Basques N. S. Bında S. M. Fıgueıredo

Öz

In different countries, propolis has been
used as food supplement, which provides organic balance of immune system and as
alternative treatment for some diseases^1,2. Studies have shown that due to the presence of
flavonoids in its chemical composition², propolis has
anti-inflammatory immunomodulator, antiproliferative, antibacterial, antiviral
and antioxidant properties^2,3. Candidiasis
caused by species of Candida genus has high incidence due to the
increasing number of immune suppressed people. It has being observed an
enhancement of resistance of these fungi to the actual antifungals³. In
this work ethanol extracts of green (GrProp) and red propolis (RdProp) were
subjected to in vitro assays against six C. albicans ATCC strains
and 10 clinical isolates. Minimum inhibitory concentration of extracts was
determined. The extracts stood out in relation to the growth inhibition of all
ATCC Candida tested, with concentrations varying from 125.0-1000.0μg/mL
(25% RdProp) and 500-2000μg/mL (100% GrProp). In relation to inhibition of
growth of all tested Candida spp.,best results were found for extract
25% RdProp (125-1000μg/mL) and 100% GrProp (500 -2000 µg/mL). Due to observed
anti-Candida activity was inferred that RdProp have potential to be used
against candidiasis.

Acknowledgements.
To
Conselho Nacional de Pesquisas (CNPq) for financial support (Project:
421544/2016-3)

Anahtar Kelimeler

Green propolis, Red propolis, In vitro, Candida spp

Kaynakça

• 1. Babaei, S, Rahimi, S, KarimiTorshizi, MA, Tahmasebi, G, KhaleghiMiran, SN (2016). Effects of propolis, royal jelly, honey and bee pollen on growth performance and immune system of Japanese quails.Veterinary Research Forum, 7(1), 13–20.
• 2. Daugsch A, Moraes CS, Fort P, Park YK (2008).Brazilian Red Propolis - Chemical Composition and Botanical Origin.Evid-BasedComplementAlternMed ECAM. 8;5(4):435–441.
• 3. Freitas, M.C.D.; De Oliveira, D.T.; De Miranda, M.B.; Vieira-Filho, S.A.; Caligiorne, R.B. De Figueiredo, S.M. (2017). Biological activities of red propolis: a rewiew. Recent Pat EndocrMetab Immune Drug Discov, 11(1):3-12