Levels of paraoxonase, high-density lipoprotein and total sialic acid levels in patients with polycystic ovary syndrome

Yıl 2017, Cilt: 9 Sayı: 2, 630 - 636, 30.08.2017

Haci Ahmet Deveci Gökhan Nur Merve Alpay Recep Özmerdivenli

https://doi.org/10.37212/jcnos.333052

Cited By: 1

Öz

Paraoxonase (PON1) have been considered to have a role in various
pathological processes, including inflammatory response, cardiovascular disease
and recently also in ovarian dysfunction. We aimed to evaluate relation high
density lipoprotein cholesterol (HDL) levels and PON1 activity and total sialic
acid status (TSA) levels in serum of patients with polycystic ovary syndrome
(PCOS) and healthy individuals.

Twenty PCOS patients (PCOS group) and 20 healthy nonhyperandrogenic women
(control group) were studied in the current study. Levels of HDL, TSA, and
activity of PON1 were measured in serum of PCOS patients.

Levels of PON1 activity and level of HDL were significantly lower in the
PCOS group than in the control group. TSA levels were higher in the PCOS group
than the control group. There was also a significant correlation between the parameters
and syndrome initiation.

In conclusion, patients with PCOS had high level of PON1. It might be
hypothesized that elevated serum TSA, HDL and PON1 may be associated with
increased cardiovascular risk in PCOS and/or menstrual irregularities
associated with this syndrome.

Anahtar Kelimeler

polycystic ovary syndrome, Paraoxonase, total sialic acid, high density lipoprotein, follicle stimulating hormone, reactive nitrogen species

Kaynakça

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