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THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS

Yıl 2019, Cilt: 43 Sayı: 2, 135 - 146, 01.06.2019
https://doi.org/10.33483/jfpau.487173

Öz

Objectives:
The purpose of this work is to study
the hepatoprotective properties of potassium 2-((4-amino-5-
(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate on tetracycline and
infectious hepatitis models in chickens.



Materials
and Methods:
Biochemical examination of blood and
liver serum was carried out on intact broiler chickens Cobb 500 cross. All
groups of chickens were kept separate in different cells in the same room for the
same microclimate parameters in accordance with the established requirements.



Result and Discussion: As a result of research on the model
of hepatitis in chickens caused by tetracycline, established hepatoprotective
effect of potassium compound
2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate,  which is not inferior to the referent drug - Thiotriazolin®. Based on the
results of the biochemical study, hepatoprotective properties of the
combination of the above compound with the antibiotic Saroflox®, combination of potassium 2-((4-amino-5-
(morpholinomethyl)-4H-1,2,4-triazole-3-yl) thio) acetate with  classical antibiotic Enrofloxacin® on the model of infectious hepatitis.

Kaynakça

  • 1. World Health Organization. (2017). Global hepatitis report 2017. World Health Organization.
  • 2. Popovich, V. P. (2011) Research of the Range of Hepatoprotectors in the Pharmaceutical Market of Ukraine. Pharmacology and Drug Toxicology, 1(20), 75-81.
  • 3. Popovich, V. P., Gromovik, B. P., & Glukhovsky, P. V. (2012). Market segment of hepatoprotectors in group and individual measurements. Pharmacology and Drug Toxicology, 1(26), 72-76.
  • 4. Reyes-Arellano, A., Gómez-García, O., & Torres-Jaramillo, J. (2016). Synthesis of Azolines and Imidazoles and their Use in Drug Design. Med. Chem.(Los Angeles), 6, 561-570.
  • 5. Rud, A. M., Kaplaushenko, A. G., Pruglo, E. S., & Frolova, Y. S. (2017). Hepatoprotective activity of 1, 2, 4-triazole-3-thione derivatives, which contains on C5-atomic carbon hydroxy (phenyl) methyl dependent. Farmatsevtychnyi zhurnal, (5-6), 55-63.
  • 6. Mohammed, G. J., & Hameed, I. H. (2018). Pharmacological Activities: Hepatoprotective, Cardio Protective, Anti-cancer and Anti-Microbial Activity of (Raphanus Raphanistrum Subsp. Sativus): A review. Indian Journal of Public Health, 9(3), 212-217. 7. Udom, G. J., Yemitan, O. K., Umoh, E. E., Mbagwu, H. O., Ukpe, E. E., & Thomas, P. S. (2018). Hepatoprotective Properties of Ethanol Seed Extract of Citrus paradisi Macfad (Grape Fruit) Against Paracetamol-Induced Hepatotoxicity in Wistar Rats. Journal of Herbal Drugs (An International Journal on Medicinal Herbs), 8(4), 219-227.
  • 8. Mari, G., Catalani, S., Antonini, E., De Crescentini, L., Mantellini, F., Santeusanio, S., & Palma, F. (2018). Synthesis and biological evaluation of novel heteroring-annulated pyrrolino-tetrahydroberberine analogues as antioxidant agents. Bioorganic & medicinal chemistry, 26(18), 5037-5044.
  • 9. Vyshtakalyuk, A. B., Nazarov, N. G., Zobov, V. V., Abdulkhakov, S. R., Minnekhanova, O. A., Semenov, V. E., & Reznik, V. S. (2017). Evaluation of the hepatoprotective effect of L-ascorbate 1-(2-hydroxyethyl)-4, 6-dimethyl-1, 2-dihydropyrimidine-2-one upon exposure to carbon tetrachloride. Bulletin of experimental biology and medicine, 162(3), 340-342.
  • 10. Sachdeva, M., Chadha, R., Kumar, A., Karan, M., Singh, T., & Dhingra, S. (2015). Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats. Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats. Indian Journal of Experimental Biology,53, 803-809.
  • 11. Tiotriazolin® tablets - instructions, analogues, composition, indications, reviews. Arterium Corporation. Reference http://compendium.com.ua/info/7043/tiotriazolin-sup-sup-. Published 2018. Accessed November 20, 2018.
  • 12. Bushueva, I., Parchenko, V., Shcherbyna, R., Safonov, A., Kaplaushenko, A., Gutyj, B., & Hariv, I. (2017). Tryfuzol-new original veterinary drug. J. Fac. Pharm. Ankara/Ankara Ecz. Fak. Derg, 41(1), 42-49.
  • 13. Shcherbyna, R. O., Panasenko, O. I., & Knysh, Y. H. (2016). The studying of antioxidant activity of salts 2-((4-R-3-(morpholinomethylen)-4H-1, 2, 4-triazole-5-yl)thio)acetic acids. Ukraïns’ kij bìofarmacevtičnij žurnal, 1 (42), 37-48.
  • 14. Stalnaya, I.D., Garishvili, T.G. (1977). Method for the Determination of Malonic Dialdehyde Using Thiobarbituric Acid. Modern methods in biochemistry, 66-68.
  • 15. Lutsik, B.D. (2011). Clinical laboratory diagnostics. Medicine: Kiev.
  • 16. Burtis, C. A., Ashwood, E. R., & Bruns, D. E. (2012). Tietz textbook of clinical chemistry and molecular diagnostics-e-book. Elsevier Health Sciences.
  • 17. Dembińska-Kieć, A. & Naskalski, J. W. (Eds.). (2017). Diagnostyka laboratoryjna z elementami biochemii klinicznej. Edra Urban & Partner.
  • 18. Beutler, E.D., Duron Q. & Kelly B.M. (1963). A Colorimetric Method for the Determination of Serium Glutamic Oxalatic and Glutaminic Pynovic Transaminases. Journal Laboratories Clinical Medicine, 61, 882.
  • 19. Korolyuk, M. A., Ivanova, L. K., Mayorova, I. G. & Tokareva, V. A. (1988). Method For The Determination of Catalase Activity. Clinical laboratory diagnosis, 4, 44-47.
  • 20. Khalafyan, A.A. (2007). Statistica 6. Statistical Data Analysis. Textbook; Binom-Press: Moskow.
  • 21. Shcherbyna, R. O., & Vashchyk, Y. V. (2018). Histological study of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1, 2, 4-triazole-3-yl)thio)acetate (PKR-173) corrective influence on the chickens liver state in the condition of tetracycline hepatitis. Zaporožskij Medicinskij Žurnal, 3, 404-412.

TETRASİKLİN VE İNFEKSİYÖZ HEPATİT ŞARTLARI ALTINDA 1,2,4-TRİAZOL TÜREVLERİNİN KARACİĞER KORUYUCU AKTİVİTELERİNİN ARAŞTIRILMASI

Yıl 2019, Cilt: 43 Sayı: 2, 135 - 146, 01.06.2019
https://doi.org/10.33483/jfpau.487173

Öz

Amaç: Bu
çalışmanın amacı tavuklarda oluşturulan tetrasiklin ve infeksiyöz hepatit modellerinde
potasyum 2-((4-amino-5-(morfolinometil)-4H-1,2,4-triazol-3-il)tiyo)asetatın
karaciğer koruyucu özelliklerini çalışmaktır.

        Gereç ve Yöntem: Kan ve
karaciğer serumunun biyokimyasal analizi Cobb 500 cinsi sağlıklı etçi
civcivlerde yapılmıştır. Belirlenen koşullara uygun olarak aynı mikroklima
parametreleri için tüm civciv grupları aynı oda içinde farklı kafeslerde ayrı
olarak tutulmuştur.










       Sonuç ve Tartışma:
Civcivlerde tetrasiklin ile oluşturulan
hepatit modelindeki çalışmanın sonucu olarak potasyum 2-((4-amino-5-
(morfolinometil)-4H-1,2,4-triazol-3-il)tio)asetat’ın belirlenen karaciğer
koruyucu etkileri referans ilaç olan Thiotriazolin’den daha aşağıda
bulunmamıştır. Biyokimyasal çalışmanın sonuçları, yukarıda belirtilen bileşiğin
Saroflox antibiyotik ile kombinasyonunun, klasik antibiyotik Enrofloxacin ile
potasyum 2-((4-amino-5-
(morfolinometil)-4H-1,2,4-triazol-3-il)tio)asetat’ın kombinasyonunun karaciğer
koruyucu özelliklerini göstermektedir.

Kaynakça

  • 1. World Health Organization. (2017). Global hepatitis report 2017. World Health Organization.
  • 2. Popovich, V. P. (2011) Research of the Range of Hepatoprotectors in the Pharmaceutical Market of Ukraine. Pharmacology and Drug Toxicology, 1(20), 75-81.
  • 3. Popovich, V. P., Gromovik, B. P., & Glukhovsky, P. V. (2012). Market segment of hepatoprotectors in group and individual measurements. Pharmacology and Drug Toxicology, 1(26), 72-76.
  • 4. Reyes-Arellano, A., Gómez-García, O., & Torres-Jaramillo, J. (2016). Synthesis of Azolines and Imidazoles and their Use in Drug Design. Med. Chem.(Los Angeles), 6, 561-570.
  • 5. Rud, A. M., Kaplaushenko, A. G., Pruglo, E. S., & Frolova, Y. S. (2017). Hepatoprotective activity of 1, 2, 4-triazole-3-thione derivatives, which contains on C5-atomic carbon hydroxy (phenyl) methyl dependent. Farmatsevtychnyi zhurnal, (5-6), 55-63.
  • 6. Mohammed, G. J., & Hameed, I. H. (2018). Pharmacological Activities: Hepatoprotective, Cardio Protective, Anti-cancer and Anti-Microbial Activity of (Raphanus Raphanistrum Subsp. Sativus): A review. Indian Journal of Public Health, 9(3), 212-217. 7. Udom, G. J., Yemitan, O. K., Umoh, E. E., Mbagwu, H. O., Ukpe, E. E., & Thomas, P. S. (2018). Hepatoprotective Properties of Ethanol Seed Extract of Citrus paradisi Macfad (Grape Fruit) Against Paracetamol-Induced Hepatotoxicity in Wistar Rats. Journal of Herbal Drugs (An International Journal on Medicinal Herbs), 8(4), 219-227.
  • 8. Mari, G., Catalani, S., Antonini, E., De Crescentini, L., Mantellini, F., Santeusanio, S., & Palma, F. (2018). Synthesis and biological evaluation of novel heteroring-annulated pyrrolino-tetrahydroberberine analogues as antioxidant agents. Bioorganic & medicinal chemistry, 26(18), 5037-5044.
  • 9. Vyshtakalyuk, A. B., Nazarov, N. G., Zobov, V. V., Abdulkhakov, S. R., Minnekhanova, O. A., Semenov, V. E., & Reznik, V. S. (2017). Evaluation of the hepatoprotective effect of L-ascorbate 1-(2-hydroxyethyl)-4, 6-dimethyl-1, 2-dihydropyrimidine-2-one upon exposure to carbon tetrachloride. Bulletin of experimental biology and medicine, 162(3), 340-342.
  • 10. Sachdeva, M., Chadha, R., Kumar, A., Karan, M., Singh, T., & Dhingra, S. (2015). Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats. Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats. Indian Journal of Experimental Biology,53, 803-809.
  • 11. Tiotriazolin® tablets - instructions, analogues, composition, indications, reviews. Arterium Corporation. Reference http://compendium.com.ua/info/7043/tiotriazolin-sup-sup-. Published 2018. Accessed November 20, 2018.
  • 12. Bushueva, I., Parchenko, V., Shcherbyna, R., Safonov, A., Kaplaushenko, A., Gutyj, B., & Hariv, I. (2017). Tryfuzol-new original veterinary drug. J. Fac. Pharm. Ankara/Ankara Ecz. Fak. Derg, 41(1), 42-49.
  • 13. Shcherbyna, R. O., Panasenko, O. I., & Knysh, Y. H. (2016). The studying of antioxidant activity of salts 2-((4-R-3-(morpholinomethylen)-4H-1, 2, 4-triazole-5-yl)thio)acetic acids. Ukraïns’ kij bìofarmacevtičnij žurnal, 1 (42), 37-48.
  • 14. Stalnaya, I.D., Garishvili, T.G. (1977). Method for the Determination of Malonic Dialdehyde Using Thiobarbituric Acid. Modern methods in biochemistry, 66-68.
  • 15. Lutsik, B.D. (2011). Clinical laboratory diagnostics. Medicine: Kiev.
  • 16. Burtis, C. A., Ashwood, E. R., & Bruns, D. E. (2012). Tietz textbook of clinical chemistry and molecular diagnostics-e-book. Elsevier Health Sciences.
  • 17. Dembińska-Kieć, A. & Naskalski, J. W. (Eds.). (2017). Diagnostyka laboratoryjna z elementami biochemii klinicznej. Edra Urban & Partner.
  • 18. Beutler, E.D., Duron Q. & Kelly B.M. (1963). A Colorimetric Method for the Determination of Serium Glutamic Oxalatic and Glutaminic Pynovic Transaminases. Journal Laboratories Clinical Medicine, 61, 882.
  • 19. Korolyuk, M. A., Ivanova, L. K., Mayorova, I. G. & Tokareva, V. A. (1988). Method For The Determination of Catalase Activity. Clinical laboratory diagnosis, 4, 44-47.
  • 20. Khalafyan, A.A. (2007). Statistica 6. Statistical Data Analysis. Textbook; Binom-Press: Moskow.
  • 21. Shcherbyna, R. O., & Vashchyk, Y. V. (2018). Histological study of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1, 2, 4-triazole-3-yl)thio)acetate (PKR-173) corrective influence on the chickens liver state in the condition of tetracycline hepatitis. Zaporožskij Medicinskij Žurnal, 3, 404-412.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Roman Shcherbyna 0000-0002-9742-0284

Yevgenia Vashchyk Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2019
Gönderilme Tarihi 23 Kasım 2018
Kabul Tarihi 3 Mart 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 43 Sayı: 2

Kaynak Göster

APA Shcherbyna, R., & Vashchyk, Y. (2019). THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS. Journal of Faculty of Pharmacy of Ankara University, 43(2), 135-146. https://doi.org/10.33483/jfpau.487173
AMA Shcherbyna R, Vashchyk Y. THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS. Ankara Ecz. Fak. Derg. Haziran 2019;43(2):135-146. doi:10.33483/jfpau.487173
Chicago Shcherbyna, Roman, ve Yevgenia Vashchyk. “THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS”. Journal of Faculty of Pharmacy of Ankara University 43, sy. 2 (Haziran 2019): 135-46. https://doi.org/10.33483/jfpau.487173.
EndNote Shcherbyna R, Vashchyk Y (01 Haziran 2019) THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS. Journal of Faculty of Pharmacy of Ankara University 43 2 135–146.
IEEE R. Shcherbyna ve Y. Vashchyk, “THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS”, Ankara Ecz. Fak. Derg., c. 43, sy. 2, ss. 135–146, 2019, doi: 10.33483/jfpau.487173.
ISNAD Shcherbyna, Roman - Vashchyk, Yevgenia. “THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS”. Journal of Faculty of Pharmacy of Ankara University 43/2 (Haziran 2019), 135-146. https://doi.org/10.33483/jfpau.487173.
JAMA Shcherbyna R, Vashchyk Y. THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS. Ankara Ecz. Fak. Derg. 2019;43:135–146.
MLA Shcherbyna, Roman ve Yevgenia Vashchyk. “THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS”. Journal of Faculty of Pharmacy of Ankara University, c. 43, sy. 2, 2019, ss. 135-46, doi:10.33483/jfpau.487173.
Vancouver Shcherbyna R, Vashchyk Y. THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS. Ankara Ecz. Fak. Derg. 2019;43(2):135-46.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.