Evaluation of olfactory function in migraineurs during the migraine-free period with odor identification test

Yıl 2014, Cilt: 4 Sayı: 1, 1 - 5, 01.03.2014

Hakan Tekeli Mehmet Güney Şenol Fatih Özdağ Mehmet Saraçoğlu Halit Yaşar Mustafa Tansel Kendirli Aytuğ Altundağ Melih Çayönü Murat Salihoğlu Türker Türker

https://doi.org/10.2399/jmu.2014001001

Öz

Objective: Despite the fact that there are many studies about the osmophobia and migraine, we have very little knowledge about the olfactory abilities of migraineurs during the period between the attacks. So, the aim of this study was to evaluate the olfactory function of migraineurs during the period without headaches with odor identification test. Methods: Two hundred and ninety healthy people aged 16 to 65 years (152 female, 138 male) and 84 migraine patients aged 18 to 55 years (47 female, 37 male) were studied. The participants with migraine were selected from the patients who applied to headache outpatient clinic for assessment. Participants, appropriate to the study, were physically and neurologically examined in detail and then they were taken to the test room in order to be screened with Short Smell Test Battery of GATA Haydarpaşa (GULTEST). Results: The mean GULTEST score of the migraine group was less than the healthy group and the difference was significant. The effect of gender, cigarette smoking and disease status (migraine) on GULTEST scores was evaluated by linear regression model. It was found that females had higher odor identification scores than males in both migraineurs and controls. On the other hand, cigarette smoking had a significant negative effect on GULTEST scores. Furthermore, migraine had a significant negative effect on GULTEST scores. Conclusion: Our study showed that even during the headache-free period, migraineurs might have reduced olfactory abilities.

Anahtar Kelimeler

Migraine, smell, olfaction disorders, headache

Migren hastalarında atak olmayan dönemde koku tanımlama testi ile koku fonksiyonunun değerlendirilmesi

Öz

Amaç: Osmophobia ve migren konusunda birçok çalışmanın varlığına rağmen, migren hastalarının ataklar arası dönemde koku alma yetenekleri hakkında çok az bilgiye sahibiz. Bu nedenle bu çalışmanın amacı migren hastalarının başağrısı olmayan dönemde koku tanımlama testi ile koku alma fonksiyonlarının değerlendirilmesidir. Yöntem: Yaşları 16-65 arasında olan 290 sağlıklı birey (152 kadın, 138 erkek) ve yaşları 18-55 arasında olan 84 migren hastası (47 kadın, 37 erkek) çalışmaya dahil edildi. Migreni olan katılımcılar değerlendirilmek üzere başağrısı polikliniğine başvuran hastalardan seçildi. Çalışmaya uygun olan katılımcılar nörolojik ve fiziksel olarak detaylı bir şekilde değerlendirildi ve daha sonra GATA Haydarpaşa Kısa Koku Test Bataryası (GULTEST) ile değerlendirme yapılması için test odasına alındı. Bulgular: Migren grubunun ortalama GULTEST skoru sağlıklı gruba göre daha az idi ve fark anlamlıydı. GULTEST skorlarına cinsiyetin, sigara içmenin ve hastalık durumunun (migren) etkisi lineer regresyon modeli ile değerlendirildi. Hem migren hastalarında hem de sağlıklı kontrollerde kadınların erkeklere göre daha yüksek koku tanımla skorları aldıkları saptandı. Buna karşılık, sigara içmenin GULTEST skorları üzerinde anlamlı bir olumsuz etkisi vardı. Ayrıca, migrenin de GULTEST skorları üzerinde anlamlı bir olumsuz etkisi vardı. Sonuç: Araştırmamız migren hastalarında başağrısı olmadığı dönemlerde dahi koku alma yeteneklerinin azalmış olabileceğini göstermiştir.

Anahtar Kelimeler

Migren, koku, koku alma bozuklukları, başağrısı

Kaynakça

• Stovner LJ, Zwart JA, Hagen K, Terwindt GM, Pascual J. Epidemiology of headache in Europe. Eur J Neurol 2006;13:333-45.
• Russell MB, Rasmussen BK, Thorvaldsen P, Olesen J. Prevalence and sex-ratio of the subtypes of migraine. Int J Epidemiol 1995;24: 612-8.
• Kelman L. The place of osmophobia and taste abnormalities in migraine classification: a tertiary care study of 1237 patients. Cephalalgia 2004;24:940-6.
• Kelman L. Osmophobia and taste abnormality in migraineurs: a tertiary care study. Headache 2004;44:1019-23.
• Morillo LE, Alarcon F, Aranaga N, et al. Clinical characteristics and patterns of medication use of migraineurs in Latin America from 12 cities in 6 countries. Headache 2005;45:118-26.
• Zanchin G, Dainese F, Trucco M, et al. Osmophobia in migraine and tension-type headache and its clinical features in patients with migraine. Cephalalgia 2007;27:1061-8.
• Frasnelli J, Hummel T. Olfactory dysfunction and daily life. Eur Arch Otorhinolaryngol 2005;262:231-5.
• Hong SC, Holbrook EH, Leopold DA, Hummel T. Distorted olfactory perception: a systematic review. Acta Otolaryngol 2012; 132 Suppl 1:S27-31.
• Demarquay G, Royet JP, Giraud P, Chazot G, Valade D, Ryvlin P. Rating of olfactory judgements in migraine patients. Cephalalgia 2006:26:1123-30.
• Zanchin G, Dainese F, Mainardi F, Mampreso E, Perin C, Maggioni F. Osmophobia in primary headaches. J Headache Pain 2005;6:213-5.
• Sjöstrand C, Savic I, Laudon-Meyer E, Hillert L, Lodin K, Waldenlind E. Migraine and olfactory stimuli. Curr Pain Headache Rep 2010;14:244-51.
• Stankewitz A, May A. Increased limbic and brainstem activity dur- ing migraine attacks following olfactory stimulation. Neurology 2011;77:476-82.
• Coleman ER, Grosberg BM, Robbins MS. Olfactory hallucina- tions in primary headache disorders: case series and literature review. Cephalalgia 2011;31:1477-89.
• Saisu A, Tatsumoto M, Hoshiyama E, Aiba S, Hirata K. Evaluation of olfaction in patients with migraine using an odour stick identifi- cation test. Cephalalgia 2011;31:1023-8.
• Snyder RD, Drummond PD. Olfaction in migraine. Cephalalgia 1997;17:729-32.
• Hirsch AR. Olfaction in migraineurs. Headache 1992;32:233-36.
• Headache Classification Subcommittee of the International Headache Society. The international classification of headache dis- orders: 2nd edition. Cephalalgia 2004;24 Suppl 1:9-160
• Doty RL, Shaman P, Dann M. Development of the University of Pennsylvania Smell Identification Test: a standardized microen- capsulated test of olfactory function (UPSIT). Physiol Behav 1984;32:489-502.
• Hummel T, Sekinger B, Wolf S, Pauli E, Kobal G. “Sniffin’ Sticks”: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 1997;22:39-52.
• Kobal G, Klimek L, Wolfensberger M, et al. Multicenter investi- gation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identifi- cation, odor discrimination, and olfactory thresholds. Eur Arch Otorhinolaryngol 2000;257:205-11.
• Kobal G, Hummel T. Olfactory and intranasal trigeminal event- related potentials in anosmic patients. Laryngoscope 1998;108: 1033-5.
• Leopold DA, Myerrose G. Diagnosis and treatment of distorted olfactory perception. In: Kurihara K, Suzuki N, Ogawa H, editors. Olfaction and taste XI. Tokyo: Springer-Verlag; 1994. p. 618-22.
• Leopold DA. Distorted olfactory perception. In: Doty RL, editor. Handbook of olfaction and gustation. New York: Marcel Dekker; 1995. p. 441-54.
• Conti MZ, Vicini-Chilovi B, Riva M, et al. Odor identification deficit predicts clinical conversion from mild cognitive impairment to dementia due to Alzheimer's disease. Arch Clin Neuropsychol 2013;28:391-9.
• Schofield PW, Ebrahimi H, Jones AL, Bateman GA, Murray SR. An olfactory ‘stress test’ may detect preclinical Alzheimer’s disease. BMC Neurol 2012;12:24.
• Murphy C, Bacon AW, Bondi MW, Salmon DP. Apolipoprotein E status is associated with odor identification deficits in “normal” older persons. Ann NY Acad Sci 1998;855:744-50.
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• Please cite this article as: Tekeli H, Şenol MG, Özda¤ F, Saraço¤lu M, Yaflar H, Kendirli MT, Altunda¤ A, Çayönü M, Saliho¤lu M, Türker T.
• Evaluation of olfactory function in migraineurs during the migraine-free period with odor identification test. J Med Updates 2014;4(1):1-5.