Year 2019, Volume 3, Issue 1, Pages 1 - 3 2019-01-27

Paratiroid adenom volümünün preoperatif biyokimyasal parametreler ile ilişkisi
Relationship of parathyroid adenoma volume with preoperative biochemical parameters

Serhat Özçelik [1] , Süleyman Baş [2] , Mehmet Çelik [3] , Sibel Temiz [4] , Melike Özçelik [5] , Pembegül Güneş [6] , Hasret Cengiz [7] , Yasemin Tütüncü [8] , Hülya Ilıksu Gözü [9]

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Amaç: Primer hiperparatiroidizm (PHPT), paratiroid bezlerinden otonom olarak aşırı parathormon salgılanması sonucu oluşan, hiperkalsemi veya normokalseminin görüldüğü klinik bir tablodur. Serum paratiroid hormonu (iPTH), kalsiyum (Ca), fosfor (P) seviyeleri ve vitamin D düzeyleri (25-OH D3) ile adenom hacmi arasında anlamlı bir ilişki bulunması, paratiroid adenomunun rezeksiyonunun boyutunu belirlemek için prediktif değere sahip olabilir.Biz de bu çalışmamızda preoperatif biyokimyasal parametreler ile paratiroid adenom volümü arasındaki ilişkiyi inceledik.

Yöntemler: İstanbul Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Endokrinoloji polikliniğinde 2011-2014 yılları arasında primer hiperparatiroidi tanısıyla takip edilen, operasyon sonrasında histopatolojik olarak soliter paratiroid adenomu tanısı konmuş 52 hasta çalışmaya alındı. Adenom hacmi ile preoperatif serum parathormon (iPTH), düzeltilmiş Ca, P, 25-OH D3, 24 saatlik idrarda kalsiyum düzeyi arasında korelasyon analizi yapıldı. Çalışma cross-sectional olarak dizayn edildi.

Bulgular: Çalışmaya alınan elli iki hastanın 45’i kadın (%86,5), 7’si erkekti (%13,5). Hastaların yaş ortalaması 53,538 ± 14,996 yıldı. Hastaların ortalama preoperatif iPTH düzeyi 371,423 ± 341,857 pg/dl, ortalama düzeltilmiş Ca düzeyi 11,652 ± 0,947 mg/dl, ortalama fosfor düzeyi 2,285 ± 0,434 mg/dl, ortalama 25-OH D3 düzeyi 11,442 ± 6,120 ng/ml, 24 saatlik idrarda kalsiyum düzeyi 337,486 ± 213,658 mg/24 saat olarak bulundu. Hastaların hesaplanan paratiroid adenom volüm ortalaması 1.612 ± 2 cm3 (0,0060-11,510) idi. Paratiroid adenom volümü ile parathormon düzeyleri ve 24 saatlik idrar kalsiyum düzeyleri arasında pozitif yönde, 25-hidroksi vitamin D düzeyleri arasında negatif yönde korelasyon saptandı. 

Sonuç: PHPT hastalarda adenom boyutu parathormon ve vitamin D düzeyi ile korelasyon göstermektedir. Bu nedenle, preoperatif iPTH ve vitamin D düzeylerinin adenom boyutu hakkında prediktif değere sahip olabileceğini düşünmekteyiz.


Aim: Primary hyperparathyroidism (PHPT) is a clinical presentation of hypercalcemia resulting from autonomous excessive parathyroid secretion from parathyroid glands. Significant correlation between serum parathyroid hormone (iPTH), calcium (Ca), phosphorus (P) and 25-OH D3 levels and adenoma volume, have a predictive value to determine the size of parathyroid adenoma resection. In this study, we examined the relation between preoperative biochemical parameters and resected parathyroid adenoma volume.

Methods: Fifty-two patients with PHPT diagnosed in the endocrinology outpatient clinic of Istanbul Haydarpaşa Numune Research Hospital, between 2011 and 2014 were included in the study. Histopathological diagnosis of solitary parathyroid adenomas was made. Correlation analysis was performed between adenoma volume and preoperative serum iPTH, corrected Ca, P, 25-OH D3 and 24 hour urinary calcium levels. The study was designed a cross-sectional study.

Results: Fifty-two patients studied, 45 were female and 7 were male. The mean age of the patients was 53.538 ± 14.996 years. The mean preoperative iPTH level was 371.423 ± 341.8 pg / dl, corrected Ca level was 11.652 ± 0.947 mg / dl, phosphorus level was 2.285 ± 0.434 mg / dl and 25-OH D3 level was 11.442 ± 6.120 ng /dl. The calculated parathyroid adenoma volume averaged 1.612 ± 2 cm3. Correlation between parathyroid adenoma volume with parathormone levels and 24 hour urine calcium levels was positive whereas 25-OH D3 levels were negatively correlated with adenoma volume.

Conclusion: The adenoma size correlates with iPTH and vitamin D levels in PHPT patients. These levels may have predictive value about adenoma volume.


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Primary Language en
Subjects General and Internal Medicine
Journal Section Research article
Authors

Author: Serhat Özçelik (Primary Author)
Institution: Haydarpaşa Numune Training and Research Hospital, Department of Endocrinology and Metabolism Clinic, Istanbul
Country: Turkey


Author: Süleyman Baş
Institution: Haydarpaşa Numune Training and Research Hospital, Department of Internal Medicine , Istanbul
Country: Turkey


Author: Mehmet Çelik
Institution: Haydarpaşa Numune Training and Research Hospital, Department of Endocrinology and Metabolism Clinic, Istanbul
Country: Turkey


Author: Sibel Temiz
Institution: Haydarpaşa Numune Training and Research Hospital, Department of Endocrinology and Metabolism Clinic, Istanbul
Country: Turkey


Author: Melike Özçelik
Institution: Kartal Lütfü Kırdar Training and Research Hospital, Department of Medical Oncology Clinic, Istanbul
Country: Turkey


Author: Pembegül Güneş
Institution: Haydarpaşa Numune Training and Research Hospital, Department of Pathology, Istanbul
Country: Turkey


Author: Hasret Cengiz
Institution: Haydarpaşa Numune Training and Research Hospital, Department of Endocrinology and Metabolism Clinic, Istanbul
Country: Turkey


Author: Yasemin Tütüncü
Institution: Haydarpaşa Numune Training and Research Hospital, Department of Endocrinology and Metabolism Clinic, Istanbul
Country: Turkey


Author: Hülya Ilıksu Gözü
Institution: Marmara University Training and Research Hospital, Department of Endocrinology and Metabolism Clinic, Istanbul
Country: Turkey


Dates

Publication Date: January 27, 2019

Bibtex @research article { josam435391, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {Fatih BAŞAK}, year = {2019}, volume = {3}, pages = {1 - 3}, doi = {10.28982/josam.435391}, title = {Relationship of parathyroid adenoma volume with preoperative biochemical parameters}, key = {cite}, author = {Özçelik, Serhat and Baş, Süleyman and Çelik, Mehmet and Temiz, Sibel and Özçelik, Melike and Güneş, Pembegül and Cengiz, Hasret and Tütüncü, Yasemin and Ilıksu Gözü, Hülya} }
APA Özçelik, S , Baş, S , Çelik, M , Temiz, S , Özçelik, M , Güneş, P , Cengiz, H , Tütüncü, Y , Ilıksu Gözü, H . (2019). Relationship of parathyroid adenoma volume with preoperative biochemical parameters. Journal of Surgery and Medicine, 3 (1), 1-3. DOI: 10.28982/josam.435391
MLA Özçelik, S , Baş, S , Çelik, M , Temiz, S , Özçelik, M , Güneş, P , Cengiz, H , Tütüncü, Y , Ilıksu Gözü, H . "Relationship of parathyroid adenoma volume with preoperative biochemical parameters". Journal of Surgery and Medicine 3 (2019): 1-3 <http://dergipark.org.tr/josam/issue/42845/435391>
Chicago Özçelik, S , Baş, S , Çelik, M , Temiz, S , Özçelik, M , Güneş, P , Cengiz, H , Tütüncü, Y , Ilıksu Gözü, H . "Relationship of parathyroid adenoma volume with preoperative biochemical parameters". Journal of Surgery and Medicine 3 (2019): 1-3
RIS TY - JOUR T1 - Relationship of parathyroid adenoma volume with preoperative biochemical parameters AU - Serhat Özçelik , Süleyman Baş , Mehmet Çelik , Sibel Temiz , Melike Özçelik , Pembegül Güneş , Hasret Cengiz , Yasemin Tütüncü , Hülya Ilıksu Gözü Y1 - 2019 PY - 2019 N1 - doi: 10.28982/josam.435391 DO - 10.28982/josam.435391 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 1 EP - 3 VL - 3 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.435391 UR - https://doi.org/10.28982/josam.435391 Y2 - 2018 ER -
EndNote %0 Journal of Surgery and Medicine Relationship of parathyroid adenoma volume with preoperative biochemical parameters %A Serhat Özçelik , Süleyman Baş , Mehmet Çelik , Sibel Temiz , Melike Özçelik , Pembegül Güneş , Hasret Cengiz , Yasemin Tütüncü , Hülya Ilıksu Gözü %T Relationship of parathyroid adenoma volume with preoperative biochemical parameters %D 2019 %J Journal of Surgery and Medicine %P -2602-2079 %V 3 %N 1 %R doi: 10.28982/josam.435391 %U 10.28982/josam.435391
ISNAD Özçelik, Serhat , Baş, Süleyman , Çelik, Mehmet , Temiz, Sibel , Özçelik, Melike , Güneş, Pembegül , Cengiz, Hasret , Tütüncü, Yasemin , Ilıksu Gözü, Hülya . "Relationship of parathyroid adenoma volume with preoperative biochemical parameters". Journal of Surgery and Medicine 3 / 1 (January 2019): 1-3. https://doi.org/10.28982/josam.435391
AMA Özçelik S , Baş S , Çelik M , Temiz S , Özçelik M , Güneş P , Cengiz H , Tütüncü Y , Ilıksu Gözü H . Relationship of parathyroid adenoma volume with preoperative biochemical parameters. J Surg Med. 2019; 3(1): 1-3.
Vancouver Özçelik S , Baş S , Çelik M , Temiz S , Özçelik M , Güneş P , Cengiz H , Tütüncü Y , Ilıksu Gözü H . Relationship of parathyroid adenoma volume with preoperative biochemical parameters. Journal of Surgery and Medicine. 2019; 3(1): 3-1.