Year 2016, Volume 3, Issue 3, Pages 47 - 58 2017-01-08

Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads

Rukiye Yavaşer [1] , Onur Korkmaz [2] , Bernis Girgin [3] , Çağdaş Sunna [4] , Arife Alev Karagözler [5]

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The entrapment of tamoxifen onto alginate-gum arabic beads and the production of controlled drug release was investigated in this study. The polymeric system that would provide the controlled release of tamoxifen was formed using alginate and gum arabic. In the first phase of the study, the optimization of the alginate-gum arabic beads production was conducted; then the study continued with drug entrapment experiments. Tamoxifen entrapment yield was found to be approximately 90% of initial tamoxifen concentration. In vitro drug release experiments were performed in simulated gastric juice and intestinal fluid where the tamoxifen release was 20% and 53% of the initial drug present, respectively. As a result of this study, it is expected that a valuable contribution to the field of controlled drug release system production is realized.

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Journal Section Articles
Authors

Author: Rukiye Yavaşer

Author: Onur Korkmaz

Author: Bernis Girgin

Author: Çağdaş Sunna

Author: Arife Alev Karagözler

Dates

Publication Date: January 8, 2017

Bibtex @ { jotcsa287255, journal = {Journal of the Turkish Chemical Society Section A: Chemistry}, issn = {}, eissn = {2149-0120}, address = {Turkish Chemical Society}, year = {2017}, volume = {3}, pages = {47 - 58}, doi = {10.18596/jotcsa.77290}, title = {Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads}, key = {cite}, author = {Yavaşer, Rukiye and Korkmaz, Onur and Girgin, Bernis and Sunna, Çağdaş and Karagözler, Arife Alev} }
APA Yavaşer, R , Korkmaz, O , Girgin, B , Sunna, Ç , Karagözler, A . (2017). Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads. Journal of the Turkish Chemical Society Section A: Chemistry, 3 (3), 47-58. DOI: 10.18596/jotcsa.77290
MLA Yavaşer, R , Korkmaz, O , Girgin, B , Sunna, Ç , Karagözler, A . "Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads". Journal of the Turkish Chemical Society Section A: Chemistry 3 (2017): 47-58 <http://dergipark.org.tr/jotcsa/issue/27290/287255?publisher=turchemsoc?publisher=turchemsoc>
Chicago Yavaşer, R , Korkmaz, O , Girgin, B , Sunna, Ç , Karagözler, A . "Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads". Journal of the Turkish Chemical Society Section A: Chemistry 3 (2017): 47-58
RIS TY - JOUR T1 - Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads AU - Rukiye Yavaşer , Onur Korkmaz , Bernis Girgin , Çağdaş Sunna , Arife Alev Karagözler Y1 - 2017 PY - 2017 N1 - doi: 10.18596/jotcsa.77290 DO - 10.18596/jotcsa.77290 T2 - Journal of the Turkish Chemical Society Section A: Chemistry JF - Journal JO - JOR SP - 47 EP - 58 VL - 3 IS - 3 SN - -2149-0120 M3 - doi: 10.18596/jotcsa.77290 UR - https://doi.org/10.18596/jotcsa.77290 Y2 - 2019 ER -
EndNote %0 Journal of the Turkish Chemical Society Section A: Chemistry Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads %A Rukiye Yavaşer , Onur Korkmaz , Bernis Girgin , Çağdaş Sunna , Arife Alev Karagözler %T Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads %D 2017 %J Journal of the Turkish Chemical Society Section A: Chemistry %P -2149-0120 %V 3 %N 3 %R doi: 10.18596/jotcsa.77290 %U 10.18596/jotcsa.77290
ISNAD Yavaşer, Rukiye , Korkmaz, Onur , Girgin, Bernis , Sunna, Çağdaş , Karagözler, Arife Alev . "Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads". Journal of the Turkish Chemical Society Section A: Chemistry 3 / 3 (January 2017): 47-58. https://doi.org/10.18596/jotcsa.77290
AMA Yavaşer R , Korkmaz O , Girgin B , Sunna Ç , Karagözler A . Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads. JOTCSA. 2017; 3(3): 47-58.
Vancouver Yavaşer R , Korkmaz O , Girgin B , Sunna Ç , Karagözler A . Production and Investigation of Controlled Drug Release Properties of Tamoxifen Loaded Alginate-Gum Arabic Microbeads. Journal of the Turkish Chemical Society Section A: Chemistry. 2017; 3(3): 58-47.