Seboreik Dermatitte Güncel Yaklaşım

Yıl 2016, Cilt: 17 Sayı: 2, 72 - 76, 05.04.2016

Seval Doğruk Kaçar Pınar Özuğuz

Öz

Seboreik dermatit (SD) sebase bezlerin yoğun olduğu bölgelerde kronik tekrarlayan eritemli skuamlı plaklarla seyreden inflamatuvar bir deri hastalıktır. Halen pek çok bilinmeyenin olduğu patogenezde özellikle Malassezia türlerine bağlı gelişen lokal immün yanıt sorumlu tutulmaktadır. Bunun yanında Demodeks türleri, bazı ilaçlar, ultraviyole, hormonlar, çeşitli çevresel ve nütrisyonel faktörler de SD ile ilişkili bulunmuştur. Tedavide topikal antifungaller, topikal zayıf etkili kortikosteroidler ve kalsinörin inhibitörleri yanında dirençli hastalarda oral izotretinoin ya da itrakonazol tercih edilebilir. Bu derleme de SD etyopatogenez ve tedavideki bugün için bilinenler özetlenmiştir.

Anahtar Kelimeler

Etyopatogenez, seboreik dermatit, tedavi

Kaynakça

• Selden ST. Seborrheic dermatitis. http://www.emedicine. com/dermatology Last updated: 25.02.2013. Last accessed: 10.2013.
• Gupta AK, Bluhm R. Seborrheic dermatitis. J Eur Acad Dermatol Venereol 2004;18(1):13-26.
• Burton JL, Pye RJ. Seborrhoea is not a feature of seborrhoeic dermatitis. Br Med J 1983;286(6372):1169-70.
• Malassez L. Note sur le champignon du pityriasis simple. Arch Physiol 1874;1: 451–9.
• Ackerman AB, Kligman AM. Some observations on dandruff. J Soc Cosmet Chem 1969;21:81–5.
• Shuster S. The aetiology of dandruff and the mode of action of therapeutic agents. Br J Dermatol 1984;111(2):235–42.
• Bergbrant IM, Johansson S, Robbins D, et al. An immunological study in patients with seborrhoeic dermatitis. Clin Exp Dermatol ;16(5):331–8. Midgley G, Hay RJ. Serological responses to Pityrosporum (Malassezia) in seborrhoeic dermatitis demonstrated by ELISA and Western blotting. Bull Soc Fr Med Mycol 1988;17:267–78.
• DeAngelis YM, Gemmer CM, Kaczvinsky JR, et al. Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity. J Investig Dermatol Symp Proc 2005;10(3):295-7.
• Gupta AK, Kohli Y, Summerbell RC, et al. Quantitative culture of Malassezia species from different body sites of individuals with or without dermatoses. Med Mycol 2001;39(3):243 –51.
• Nakabayashi A, Sei Y, Guillot J. Identification of Malassezia species isolated from patients with seborrhoeic dermatitis, atopic dermatitis, pityriasis versicolor and normal subjects. Med Mycol 2000;38(5):337–41.
• Dawson TL. Malassezia globosa and restricta: breakthrough understanding of the etiology and treatment of dandruff and seborrheic dermatitis through whole-genome analysis. J Investig Dermatol Symp Proc 2007;12(2):15–9.
• Hay RJ. Malassezia, dandruff and seborrhoeic dermatitis: an overview. Br J Dermatol 2011;165(2):2-8.
• Karincaoglu Y, Bayram N, Aycan O, Esrefoglu M. The clinical importance of Demodex folliculorum presenting with nonspecific facial signs and symptoms. J Dermatol ;31(8):618–26. Karincaoglu Y, Tepe B, Kalayci B, Atambay M, Seyhan M. Is Demodex folliculorum an aetiological factor in seborrhoeic dermatitis? Clin Exp Dermatol 2009;34(8):e516-20.
• Berg M. Epidemiological studies of the influence of sunlight on the skin. Photodermatology 1989;6(2):80–4.
• Marietta G, Rongioletti Rebora A. Seborrheic dermatitis and daylight. Acta Derm Venereol 1991;71(6):538-9.
• Yegner E. Seborrhoeic dermatitis of the face induced by PUVA treatment. Acta Derm Venereol 1983;63(4):335–9.
• Manuel F, Ranganathan S. A new postulate on two stages of dandruff: A clinical perspective. Int J Trichol 2011;3(1):3-6.
• Henderson CA, Taylor J, Cunliffe WJ. Sebum excretion rates in mothers and neonates. Br J Dermatol 2000;142(1):110-1.
• İnalöz HS, Kırtak N. The pathogenesis and treatment of seborrheic dermatitis. T Klin J Med Sci 2002;22(2):239-44.
• Binder RL, Jonelis FJ. Seborrheic dermatitis in neuroleptic- induced Parkinsonism. Arch Dermatol 1983;119(6):473-5.
• Burton JL, Cartilidge M, Shuster S. Effect of L-dopa on the seborrhea of parkinsonism. Br J Dermatol 1973;88(5):475-9.
• Burton JL, Cartlidge M, Cartlidge NEF, Shuster S. Sebum excretion in parkinsonism. Br J Dermatol 1973;88(3):263–6.
• Shuster S, Thody AJ, Goolamali SK, et al. Melanocyte stimulating hormone and Parkinsonism. Lancet ;1(7801):463-4.
• Mastrolonardo M, Diaferio A, Logroscino G. Seborrheic dermatitis, increased sebum excretion, and Parkinson’s disease: a survey of (im)possible links. Med Hypotheses 2003;60(6):907
• Ranganathan S, Mukhopadhyay T. Dandruff: The most commercially exploited skin disease. Indian J Dermatol ;55(2):130–4. Shectman R, Midgley G, Hay RJ. HIV disease and Malassezia yeasts: a quantitative study of patients presenting with seborrhoeic dermatitis. Br J Dermatol 1995;133(5):694–8.
• Soeprono FF, Schinella RA, Cockerell CJ, et al. Seborrheic- like dermatitis of acquired immunodeficiency syndrome. A clinicopathologic study. J Am Acad Dermatol 1986;14(2):242-8.
• Wikler JR, Nieboer C, Willemze R. Quantitive skin cultures of Pityrosporum yeasts in patients seropositive for the human immunodeficiency virus with and without seborrheic dermatitis. J Am Acad Dermatol 1992;27(1):37-9.
• Habif TP. Clinical Dermatology. Edinburg: Mosby, 2004;209
• Savaskan H. Seboreik Dermatit. Dermatoloji Tüzün Y, Kotogyan A, Aydemir EH ve ark (Editörler). İstanbul: Nobel Tıp Kitabevleri, 1994;330-2.
• Rigopoulos D, Ioannides D, Kalogeromitros D, Gregoriou S, Katsambas A. Pimecrolimus cream 1% vs. betamethasone valerate 1% cream in the treatment of seborrhoeic dermatitis. A randomized open-label clinical trial. Br J Dermatol ;151(5):1071–5.
• Ang-Tiu CU, Meghrajani CF, Maano CC. Pimecrolimus 1% cream for the treatment of seborrheic dermatitis: a systematic review of randomized controlled trials. Expert Rev Clin Pharmacol 2012;5(1):91-7.
• Wananukul S, Chatproedprai S, Charutragulchai W. Randomized, double-blind, split-side comparison study of moisturizer containing licochalcone vs. 1% hydrocortisone in the treatment of infantile seborrhoeic dermatitis. J Eur Acad Dermatol Venereol 2012;26(7):894-7.
• Plewig G, Jansen T. Seborrheic Dermatitis Fitzpatrick’s Dermatology in General Medicine’de. Freedberg IM, Eisen AZ, Wolff KK, et al (Editors). New York: McGraw- Hill, 2003;1198-204.
• Clark RAF, Hopkins TT. The other eczemas. Dermatology’de. Moschella SL, Hurley HJ (Editors). Philadelphia: WB Sounders Company, 1992;465-504.
• Das J, Majumdar M, Chakraborty U, Majumdar V, Mazumdar G, Nath J. Oral itraconazole for the treatment of severe seborrhoeic dermatitis. Indian J Dermatol 2011;56(5):515-6.