Year 2019, Volume 20, Issue 2, Pages 98 - 104 2019-04-29

GÜNCEL BİR ADİPOKİN: CHEMERİN
A CURRENT ADIPOKINE: CHEMERIN

Menşure Nur ÇELİK [1] , Mehtap ÜNLÜ SÖĞÜT [2]

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AMAÇ: Adipoz dokudan salgılanan chemerin kısa bir süre önce adipokin ailesine katılan, çeşitli otokrin ve parakrin etkileri olan bir sinyal molekülü ve yeni bir kemotaktik proteindir. Son yıllarda chemerin ve reseptörünün adipositlerde yüksek oranda olmak üzere karaciğer, böbrek, pankreas, hipofiz, plasenta, yumurtalık ve testislerde eksprese edildiği saptanmıştır. Bu organ ve dokular aracılığıyla enerji homeostazı, glukoz metabolizması, inflamasyon ve birçok fizyolojik sürece etki ettiği bilinmektedir. Adipogenezis, enerji metabolizması ve inflamasyonda rolü olduğu gösterilen bu adipokinin metabolik sendrom (MetS), obezite, Tip 2 Diabetes Mellitus (T2DM), kardiyovasküler hastalıklar, Crohn hastalığı, artrit ve kanserde rolü hakkında artan kanıtlar mevcuttur. Özellikle chemerin, obezite ile T2DM’ nin gelişimi arasında olası bir bağlantının hipotezi olarak öne sürülmüştür. Aynı zamanda plazma chemerin düzeylerinin vücut kütle indeksi, açlık serum insülini, açlık kan glukozu, plazma trigliseridleri ve total serum kolesterolü ile pozitif korelasyon gösterdiği ve yüksek yoğunluklu lipoprotein (HDL) ile negatif korelasyon gösterdiği saptanmıştır. Genel olarak, bu bulgular dolaşımdaki chemerin düzeylerinin yağlanmaya ve metabolik sendroma bağlı olduğunu, viseral adipozun obez bireylerde chemerinin değiştirilebilir bir kaynağı olduğunu düşündürmektedir. Chemerin; insulin seviyesini azaltıp, glukoz kullanımını artırarak glukoz homeostazını; glikojen sentetazı inhibe ederek T2DM’u; adiposit farklılaşmasını ve kemotaksisi düzenleyerek inflamasyonu; GLUT-4, yağ asidi sentaz, adiponektin ve leptinin salınımını düzenleyerek MetS belirteçlerini etkilemektedir. Bu nedenle obezite, T2DM, kardiyovasküler hastalıklar, inflamasyon, metabolik sendrom ve daha birçok hastalıkla ilişkisi bulunan chemerin adipokininin dolaşımdaki seviyelerini belirlemek ve düzeylerini kontrol etmek önem taşımaktadır. Literatür taramasında sıklıkla obez ve metabolik sendromlu bireylerde dolaşımdaki chemerin seviyelerinin yüksek olduğu göze çarpmaktadır. Bu derlemede chemerinin obezite ve metabolik sendromdaki etkileri ile birlikte daha az ele alınan inflamasyon, polikistik over sendromu ve diğer metabolik etkilerine yer verilmektedir.

OBJECTIVE: Chemerin secreted from adipose tissue is a signal molecule with a variety of autocrine and paracrine effects and a new chemotactic protein that recently joined the adipokine family. In recent years, chemerin and its receptor are expressed at the highest levels in adipocytes and less expressed than in the liver, kidney, pancreas, pituitary, placenta, ovary and testes. Through these organs and tissues it is known that it affects energy homeostasis, glucose metabolism, inflammation and many physiological processes. There is growing evidence that this adipokine has been shown to play a role in adipogenesis, energy metabolism and inflammation, its role in metabolic syndrome (MetS), obesity, Type 2 Diabetes Mellitus (T2DM), cardiovascular diseases, Crohn’s disease, arthritis and cancer. In particular, chemerin has been suggested as a hypothesis of a possible link between obesity and the development of T2DM. It was also found that plasma chemerin levels correlated positively with body mass index, fasting serum insulin, fasting blood glucose, plasma triglycerides and total serum cholesterol and negatively correlated with high density lipoprotein (HDL). In general, these findings indicate that circulating levels of chemerin are dependent on adiposity and metabolic syndrome, suggesting that visceral adipose is a replaceable source of chemerin in obese individuals. Chemerin affects glucose homeostasis by decreasing insulin levels and increasing glucose uptake; T2DM by inhibiting glycogen synthase; inflammation by regulating adipocyte differentiation and chemotaxis; MetS markers by regulating the release of GLUT-4, fatty acid synthase, adiponectin and leptin. Therefore, it is important to determine the levels of circulating levels of chemerin adipokinin in relation to obesity, T2DM, cardiovascular diseases, inflammation, metabolic syndrome and many other diseases. In the literature, it is frequently observed that circulating chemerin levels are high in individuals with obese and metabolic syndrome. In this review, chemerinin is associated with the effects of obesity and the metabolic syndrome, as well as less-studied inflammation, polycystic ovarian syndrome and other metabolic effects.

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Primary Language tr
Subjects Medicine
Journal Section Review
Authors

Author: Menşure Nur ÇELİK (Primary Author)

Author: Mehtap ÜNLÜ SÖĞÜT

Bibtex @review { kocatepetip557987, journal = {Kocatepe Tıp Dergisi}, issn = {1302-4612}, eissn = {2149-7869}, address = {Afyonkarahisar Sağlık Bilimleri Üniversitesi}, year = {2019}, volume = {20}, pages = {98 - 104}, doi = {10.18229/kocatepetip.557987}, title = {GÜNCEL BİR ADİPOKİN: CHEMERİN}, key = {cite}, author = {ÇELİK, Menşure Nur and ÜNLÜ SÖĞÜT, Mehtap} }
APA ÇELİK, M , ÜNLÜ SÖĞÜT, M . (2019). GÜNCEL BİR ADİPOKİN: CHEMERİN. Kocatepe Tıp Dergisi, 20 (2), 98-104. DOI: 10.18229/kocatepetip.557987
MLA ÇELİK, M , ÜNLÜ SÖĞÜT, M . "GÜNCEL BİR ADİPOKİN: CHEMERİN". Kocatepe Tıp Dergisi 20 (2019): 98-104 <http://dergipark.org.tr/kocatepetip/issue/44892/557987>
Chicago ÇELİK, M , ÜNLÜ SÖĞÜT, M . "GÜNCEL BİR ADİPOKİN: CHEMERİN". Kocatepe Tıp Dergisi 20 (2019): 98-104
RIS TY - JOUR T1 - GÜNCEL BİR ADİPOKİN: CHEMERİN AU - Menşure Nur ÇELİK , Mehtap ÜNLÜ SÖĞÜT Y1 - 2019 PY - 2019 N1 - doi: 10.18229/kocatepetip.557987 DO - 10.18229/kocatepetip.557987 T2 - Kocatepe Tıp Dergisi JF - Journal JO - JOR SP - 98 EP - 104 VL - 20 IS - 2 SN - 1302-4612-2149-7869 M3 - doi: 10.18229/kocatepetip.557987 UR - https://doi.org/10.18229/kocatepetip.557987 Y2 - 2018 ER -
EndNote %0 Kocatepe Medical Journal GÜNCEL BİR ADİPOKİN: CHEMERİN %A Menşure Nur ÇELİK , Mehtap ÜNLÜ SÖĞÜT %T GÜNCEL BİR ADİPOKİN: CHEMERİN %D 2019 %J Kocatepe Tıp Dergisi %P 1302-4612-2149-7869 %V 20 %N 2 %R doi: 10.18229/kocatepetip.557987 %U 10.18229/kocatepetip.557987
ISNAD ÇELİK, Menşure Nur , ÜNLÜ SÖĞÜT, Mehtap . "GÜNCEL BİR ADİPOKİN: CHEMERİN". Kocatepe Tıp Dergisi 20 / 2 (April 2019): 98-104. https://doi.org/10.18229/kocatepetip.557987