Derleme
BibTex RIS Kaynak Göster

Orofarenks Kanserlerinde Boyun Metastazlarına Yaklaşım

Yıl 2019, Cilt: 14 Sayı: 2, 98 - 100, 15.07.2019
https://doi.org/10.17517/ksutfd.496496

Öz

Orofarenks
kanserlerinde prognozu belirleyen en önemli parametrelerden biri boyun
metastazlarıdır. Orofaringeal tümörlerin çoğunda okült metastaz olasılığının %
20’nin üzerinde olması nedeni ile genellikle boynun elektif olarak tedavisi
önerilmektedir. Tedavi seçenekleri cerrahi veya radyoterapi olabilir. İleri
evre orofaringeal karsinomlarda ise tedavi seçenekleri boyun diseksiyonu ve
adjuvan onkolojik tedavilerle birlikte transoral cerrahi ve kemoradyoterapiyi
içermektedir. Bu makalede orofarengeal karsinomların boyun metastaz oranlarını
ve bu metastazlara yaklaşımı gözden geçirmeyi amaçladık.

Kaynakça

  • Kaynaklar1. Kato MG, Ellis MA, Nguyen SA ve ark. Predictors of contralateral-bilateral nodal disease in oropharyngeal cancer: A National Cancer Data Base Study. Head Neck 2018; 40: 338-48.2. Gottumukkala S, Pham NL, Sumer B ve ark. Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer. Oral Oncol 2017; 75:35-8.3. Derin A. T., Yaprak N. Orofarenks Tümörlerinde Boyun Diseksiyonları. Turkiye klinikleri J E. N. T. Special Topics 2017; 10: 55-8.4. İkiz A. Ö., Polack B. D. Baş Boyun Kanserlerinde Sentinal Lenf Nodu Sintigrafisi ve Biyopsisi. Nuclear Medicine Seminars 2017; 3: 121-28.5. Köhler HF, Franzi SA, Soares FA ve ark. Distribution of Metastatic Nodes in N0-1 Patients with Tonsillar Squamous Cell Carcinoma and Its Implications for Selective Neck Dissection. Turk Arch Otorhinolaryngol. 2018; 56: 139-144. 6. Tsujikawa T, Narita N, Kanno M ve ark. Role of PET/MRI in oral cavity and oropharyngeal cancers based on the 8th edition of the AJCC cancer staging system: a pictorial essay. Ann Nucl Med 2018; 32: 239-49.7. Riese CGU, Karstadt JA, Schramm A ve ark. Validity of sentinel node biopsy in early oral and oropharyngeal carcinoma. J Craniomaxillofac Surg 2018; 46: 1748-52.8. Mack MG, Rieger J, Baghi M ve ark. Cervical lymph nodes. Eur J Radiol 2008; 66: 493-500. 9. Fox HR, Robson A, Cocks H ve ark. Contralateral neck metastases in lateralised, resectable advanced stage oropharyngeal squamous cell carcinoma-Results of 57 patients undergoing bilateral selective neck dissection. Clin Otolaryngol 2018; 43: 739-41. 10.Rassekh CH, O'Malley BW Jr, Bewley AF ve ark. Feasibility and relevance of level I substation node counts in oropharyngeal carcinoma. Head Neck. 2016 Aug;38: 1194-200. 11. Taylor RJ, Wahl RL, Sharma PK ve ark. Sentinel node localization in oral cavity and oropharynx squamous cell cancer. Arch Otolaryngol Head Neck Surg. 2001;127: 970-4.12. Pitman KT, Johnson JT, Brown ML ve ark. Sentinel lymph node biopsy in head and neck squamous cell carcinoma. Laryngoscope 2002; 112: 2101-13.13. Calabrese L, Bruschini R, Ansarin M ve ark. Role of sentinel lymph node biopsy in oral cancer. Acta Otorhinolaryngol Ital. 2006; 26: 345-9.14. Zitsch RP, Todd DW, Renner GJ ve ark. Intraoperative radiolymphoscintigraphy for detection of occult nodal metastasis in patients with head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 2000; 122: 662-6. 15. Lim YC, Koo BS, Lee JS ve ark. Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. Laryngoscope 2006 Jul; 116: 1148-52.16. Tritter AG, Mehta V, Samuelson M ve ark. Incidence of contralateral-bilateral nodes in the human papillomavirus era. Laryngoscope. 2017;127: 1328-33.17. Plonowska KA, Strohl MP, Wang SJ ve ark. Human Papillomavirus-Associated Oropharyngeal Cancer: Patterns of Nodal Disease. Otolaryngol Head Neck Surg 2018; 2: 1-8.18. Stenmark MH, Shumway D, Guo C ve ark. Influence of human papillomavirus on the clinical presentation of oropharyngeal carcinoma in the United States. Laryngoscope 2017; 127: 2270-78.19. Jacobi C, Rauch J, Hagemann J ve ark. Prognostic value of the lymph node ratio in oropharyngeal carcinoma stratified for HPV-status. Eur Arch Otorhinolaryngol 2018; 275: 515-24. 20. Sood AJ, McIlwain W, O'Connell B ve ark. The association between T-stage and clinical nodal metastasis In HPV-positive oropharyngeal cancer. Am J Otolaryngol 2014; 35: 463-8.21. Lim YC, Lee SY, Lim JY ve ark. Management of contralateral N0 neck in tonsillar squamous cell carcinoma. Laryngoscope. 2005; 115: 1672-5.22. Lee DJ, Kwon MJ, Nam ES ve ark. Histopathologic predictors of lymph node metastasis and prognosis in tonsillar squamous cell carcinoma. Korean J Pathol 2013; 47: 203-10. 23. Cho JH, Lee YS, Sun DI ve ark. Prognostic impact of lymph node micrometastasis in oral and oropharyngeal squamous cell carcinomas. Head Neck 2016; 38; 1777-82.24. Spiro RH, Huvos AG, Wong GY ve ark. Predictive value of tumor thickness in squamous carcinoma confined to the tongue and floor of the mouth. Am J Surg 1986; 152: 345-50.25. Carrau RL, Barnes EL, Snyderman CH ve ark. Tumor angiogenesis as a predictor of tumor aggressiveness and metastatic potential in squamous cell carcinoma of the head and neck. Invasion Metastasis 1995; 15: 197-202.26. Cohan DM, Popat S, Kaplan SE ve ark. Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg 2009 ; 17: 88-94.27. Osborne RF, Brown JJ. Carcinoma of the oral pharynx: an analysis of subsite treatment heterogeneity. Surg Oncol Clin N Am 2004; 13: 71-80.28. Lin DT, Cohen SM, Coppit GL ve ark. Squamous cell carcinoma of the oropharynx and hypopharynx. Otolaryngol Clin North Am 2005; 38: 59-74.29. Shah JP. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am J Surg 1990; 160: 405-9.30. Gross BC, Olsen SM, Lewis JE ve ark. Level IIB lymph node metastasis in oropharyngeal squamous cell carcinoma. Laryngoscope 2013; 123: 2700-5.

Approach to Neck Metastases in Oropharyngeal Cancers

Yıl 2019, Cilt: 14 Sayı: 2, 98 - 100, 15.07.2019
https://doi.org/10.17517/ksutfd.496496

Öz

Cervical lymph
node metastasis is one of the most important prognostic parameter in
oropharyngeal carsinomas. Most oropharyngeal tumors have occult metastases
rates exceeding 20%, and elective treatment of the neck is generally
recommended. Treatment options may be surgery or radiotherapy. Options for
treatment of advanced oropharyngeal carsinomas include chemoradiotherapy or
transoral surgery with neck disection and adjuvant oncological treatment. In
this article, we aimed to review the rates of neck metastasis and the approach
of these metastases to oropharyngeal carcinomas.

Kaynakça

  • Kaynaklar1. Kato MG, Ellis MA, Nguyen SA ve ark. Predictors of contralateral-bilateral nodal disease in oropharyngeal cancer: A National Cancer Data Base Study. Head Neck 2018; 40: 338-48.2. Gottumukkala S, Pham NL, Sumer B ve ark. Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer. Oral Oncol 2017; 75:35-8.3. Derin A. T., Yaprak N. Orofarenks Tümörlerinde Boyun Diseksiyonları. Turkiye klinikleri J E. N. T. Special Topics 2017; 10: 55-8.4. İkiz A. Ö., Polack B. D. Baş Boyun Kanserlerinde Sentinal Lenf Nodu Sintigrafisi ve Biyopsisi. Nuclear Medicine Seminars 2017; 3: 121-28.5. Köhler HF, Franzi SA, Soares FA ve ark. Distribution of Metastatic Nodes in N0-1 Patients with Tonsillar Squamous Cell Carcinoma and Its Implications for Selective Neck Dissection. Turk Arch Otorhinolaryngol. 2018; 56: 139-144. 6. Tsujikawa T, Narita N, Kanno M ve ark. Role of PET/MRI in oral cavity and oropharyngeal cancers based on the 8th edition of the AJCC cancer staging system: a pictorial essay. Ann Nucl Med 2018; 32: 239-49.7. Riese CGU, Karstadt JA, Schramm A ve ark. Validity of sentinel node biopsy in early oral and oropharyngeal carcinoma. J Craniomaxillofac Surg 2018; 46: 1748-52.8. Mack MG, Rieger J, Baghi M ve ark. Cervical lymph nodes. Eur J Radiol 2008; 66: 493-500. 9. Fox HR, Robson A, Cocks H ve ark. Contralateral neck metastases in lateralised, resectable advanced stage oropharyngeal squamous cell carcinoma-Results of 57 patients undergoing bilateral selective neck dissection. Clin Otolaryngol 2018; 43: 739-41. 10.Rassekh CH, O'Malley BW Jr, Bewley AF ve ark. Feasibility and relevance of level I substation node counts in oropharyngeal carcinoma. Head Neck. 2016 Aug;38: 1194-200. 11. Taylor RJ, Wahl RL, Sharma PK ve ark. Sentinel node localization in oral cavity and oropharynx squamous cell cancer. Arch Otolaryngol Head Neck Surg. 2001;127: 970-4.12. Pitman KT, Johnson JT, Brown ML ve ark. Sentinel lymph node biopsy in head and neck squamous cell carcinoma. Laryngoscope 2002; 112: 2101-13.13. Calabrese L, Bruschini R, Ansarin M ve ark. Role of sentinel lymph node biopsy in oral cancer. Acta Otorhinolaryngol Ital. 2006; 26: 345-9.14. Zitsch RP, Todd DW, Renner GJ ve ark. Intraoperative radiolymphoscintigraphy for detection of occult nodal metastasis in patients with head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 2000; 122: 662-6. 15. Lim YC, Koo BS, Lee JS ve ark. Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. Laryngoscope 2006 Jul; 116: 1148-52.16. Tritter AG, Mehta V, Samuelson M ve ark. Incidence of contralateral-bilateral nodes in the human papillomavirus era. Laryngoscope. 2017;127: 1328-33.17. Plonowska KA, Strohl MP, Wang SJ ve ark. Human Papillomavirus-Associated Oropharyngeal Cancer: Patterns of Nodal Disease. Otolaryngol Head Neck Surg 2018; 2: 1-8.18. Stenmark MH, Shumway D, Guo C ve ark. Influence of human papillomavirus on the clinical presentation of oropharyngeal carcinoma in the United States. Laryngoscope 2017; 127: 2270-78.19. Jacobi C, Rauch J, Hagemann J ve ark. Prognostic value of the lymph node ratio in oropharyngeal carcinoma stratified for HPV-status. Eur Arch Otorhinolaryngol 2018; 275: 515-24. 20. Sood AJ, McIlwain W, O'Connell B ve ark. The association between T-stage and clinical nodal metastasis In HPV-positive oropharyngeal cancer. Am J Otolaryngol 2014; 35: 463-8.21. Lim YC, Lee SY, Lim JY ve ark. Management of contralateral N0 neck in tonsillar squamous cell carcinoma. Laryngoscope. 2005; 115: 1672-5.22. Lee DJ, Kwon MJ, Nam ES ve ark. Histopathologic predictors of lymph node metastasis and prognosis in tonsillar squamous cell carcinoma. Korean J Pathol 2013; 47: 203-10. 23. Cho JH, Lee YS, Sun DI ve ark. Prognostic impact of lymph node micrometastasis in oral and oropharyngeal squamous cell carcinomas. Head Neck 2016; 38; 1777-82.24. Spiro RH, Huvos AG, Wong GY ve ark. Predictive value of tumor thickness in squamous carcinoma confined to the tongue and floor of the mouth. Am J Surg 1986; 152: 345-50.25. Carrau RL, Barnes EL, Snyderman CH ve ark. Tumor angiogenesis as a predictor of tumor aggressiveness and metastatic potential in squamous cell carcinoma of the head and neck. Invasion Metastasis 1995; 15: 197-202.26. Cohan DM, Popat S, Kaplan SE ve ark. Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg 2009 ; 17: 88-94.27. Osborne RF, Brown JJ. Carcinoma of the oral pharynx: an analysis of subsite treatment heterogeneity. Surg Oncol Clin N Am 2004; 13: 71-80.28. Lin DT, Cohen SM, Coppit GL ve ark. Squamous cell carcinoma of the oropharynx and hypopharynx. Otolaryngol Clin North Am 2005; 38: 59-74.29. Shah JP. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am J Surg 1990; 160: 405-9.30. Gross BC, Olsen SM, Lewis JE ve ark. Level IIB lymph node metastasis in oropharyngeal squamous cell carcinoma. Laryngoscope 2013; 123: 2700-5.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derlemeler
Yazarlar

İsrafil Orhan 0000-0002-9557-7050

Nagihan Bilal 0000-0002-2850-3481

Yayımlanma Tarihi 15 Temmuz 2019
Gönderilme Tarihi 13 Aralık 2018
Kabul Tarihi 28 Ocak 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 14 Sayı: 2

Kaynak Göster

AMA Orhan İ, Bilal N. Orofarenks Kanserlerinde Boyun Metastazlarına Yaklaşım. KSÜ Tıp Fak Der. Temmuz 2019;14(2):98-100. doi:10.17517/ksutfd.496496