Year 2019, Volume 11, Issue 1, Pages 119 - 125 2019-03-25

Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement

Mine Geçgelen Cesur [1] , Tuna Onal [2] , Mehmet Dincer Bilgin [3] , Fevziye Burcu Sirin [4] , Sevinc Inan [5] , Ergun Cem Koken [6] , Afra Alkan [7] , Gokhan Cesur [8]

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Objective: The aim of this study is to investigate the effects of low intensity pulsed ultrasound on orthodontic tooth movement in rats.

Methods: For this study, 40 12-week-old adult male Wistar albino rats from the Animal Laboratory at Adnan Menderes University, Faculty of Medicine, were used. Rats were divided into four groups of ten. Group 1 was the untreated control group. In group 2, an orthodontic spring was used to move teeth. In groups 3 and 4, orthodontic treatment was combined with low intensity pulsed ultrasound at 16 J/cm2 or 48 J/cm2, respectively, for 14 days. Tooth movement was measured on day 14. Serum bone alkaline phosphatase (BALP) and C-telopeptide of type I collagen (CTX-I) levels were analyzed biochemically. The number of osteoclasts, osteoblasts and inflammatory cells, capillary density and new bone formation was determined histologically. Receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), vascular endothelial growth factor (VGEF) and transforming growth factor-β (TGF-β) were assessed using immunohistochemical staining.

Results: BALP and CTX-I levels in group 4 were significantly higher than for group 1. Tooth movement and the number of osteoclasts, inflammatory cells, and capillary density in group 4 were significantly greater than for group 2. The intensity levels of RANKL and OPG in group 4 were significantly greater than for group 2.

Conclusion: Ultrasound is noninvasive application and a promising therapy for accelerating bone remodeling during orthodontic tooth movement.

Orthodontic treatment, low intensity pulsed ultrasound, tooth movement
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Primary Language en
Subjects Health Care Sciences and Services
Published Date Mart 2019
Journal Section Articles
Authors

Author: Mine Geçgelen Cesur (Primary Author)
Country: Turkey


Author: Tuna Onal

Author: Mehmet Dincer Bilgin

Author: Fevziye Burcu Sirin

Author: Sevinc Inan

Author: Ergun Cem Koken

Author: Afra Alkan

Author: Gokhan Cesur

Bibtex @research article { ktd510808, journal = {Konuralp Medical Journal}, issn = {1309-3878}, eissn = {1309-3878}, address = {Duzce University}, year = {2019}, volume = {11}, pages = {119 - 125}, doi = {10.18521/ktd.510808}, title = {Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement}, key = {cite}, author = {Geçgelen Cesur, Mine and Onal, Tuna and Bilgin, Mehmet Dincer and Sirin, Fevziye Burcu and Inan, Sevinc and Koken, Ergun Cem and Alkan, Afra and Cesur, Gokhan} }
APA Geçgelen Cesur, M , Onal, T , Bilgin, M , Sirin, F , Inan, S , Koken, E , Alkan, A , Cesur, G . (2019). Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement. Konuralp Medical Journal, 11 (1), 119-125. DOI: 10.18521/ktd.510808
MLA Geçgelen Cesur, M , Onal, T , Bilgin, M , Sirin, F , Inan, S , Koken, E , Alkan, A , Cesur, G . "Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement". Konuralp Medical Journal 11 (2019): 119-125 <http://dergipark.org.tr/ktd/issue/44366/510808>
Chicago Geçgelen Cesur, M , Onal, T , Bilgin, M , Sirin, F , Inan, S , Koken, E , Alkan, A , Cesur, G . "Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement". Konuralp Medical Journal 11 (2019): 119-125
RIS TY - JOUR T1 - Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement AU - Mine Geçgelen Cesur , Tuna Onal , Mehmet Dincer Bilgin , Fevziye Burcu Sirin , Sevinc Inan , Ergun Cem Koken , Afra Alkan , Gokhan Cesur Y1 - 2019 PY - 2019 N1 - doi: 10.18521/ktd.510808 DO - 10.18521/ktd.510808 T2 - Konuralp Medical Journal JF - Journal JO - JOR SP - 119 EP - 125 VL - 11 IS - 1 SN - 1309-3878-1309-3878 M3 - doi: 10.18521/ktd.510808 UR - https://doi.org/10.18521/ktd.510808 Y2 - 2019 ER -
EndNote %0 Konuralp Medical Journal Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement %A Mine Geçgelen Cesur , Tuna Onal , Mehmet Dincer Bilgin , Fevziye Burcu Sirin , Sevinc Inan , Ergun Cem Koken , Afra Alkan , Gokhan Cesur %T Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement %D 2019 %J Konuralp Medical Journal %P 1309-3878-1309-3878 %V 11 %N 1 %R doi: 10.18521/ktd.510808 %U 10.18521/ktd.510808
ISNAD Geçgelen Cesur, Mine , Onal, Tuna , Bilgin, Mehmet Dincer , Sirin, Fevziye Burcu , Inan, Sevinc , Koken, Ergun Cem , Alkan, Afra , Cesur, Gokhan . "Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement". Konuralp Medical Journal 11 / 1 (March 2019): 119-125. https://doi.org/10.18521/ktd.510808