Year 2016, Volume 1, Issue 1, Pages 29 - 39 2016-06-23

HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ

Ezgi ŞABABOĞLU [1] , Hülya TÜRÜTOĞLU [2]

774 741

Antimikrobiyal peptidler, antimikrobiyal, kemotaktik ve immun düzenleyici aktivitelerinden dolayı doğal dirençte önemli rollere sahiptirler. Koruyucu veya terapötik bir ilaç olarak kullanılabileceklerinden dolayı yeni kuşak antibiyotikler olarak da adlandırılmaktadırlar. Memelilerde katelisidinler ve defensinler olmak üzere iki önemli antimikrobiyal peptid grubu vardır. Bu iki grup arasında da en yaygın peptidler, beta-tabakalı, üç intramoleküler disülfit bağı içeren defensinlerdir. Bu derlemede hayvanlarda sentezlenen defensinlerin yapısal özellikleri, antimikrobiyal etkinlikleri, bağışıklıktaki rolleri ile gelecekte kullanım alanları üzerine bilgiler sunuldu.

Defensin, doğal direnç, antimikrobiyal aktivite
  • Ganz T. Defensins: Antimicrobıal peptides of innate immunity. Nat Rev Immunol. 2003; 3: 710-721. DOI: 10.1038/nri1180.
  • Hazlett L, Wu M. Defensins in innate immunity. Cell Tissue Res. 2011; 343: 175-188. DOI: 10.1007/s00441-010-1022-4.
  • Bagnicka E, Strzałkowska N, Jóźwik A, Krzyżewski J, Horbańczuk J, Zwierzchowski L. Expression and polymorphism of defensins in farm animals. Acta Biochim Pol. 2010; 57: 487-497.
  • Yang D, Biragyn A, Kwak LW, Oppenheim JJ. Mammalian defensins in immunity: more than just microbicidal. Trends Microbiol. 2002; 23: 291-296. PMID: 12072367.
  • Lehrer RI, Ganz T. Defensins of vertebrate animals. Curr Opin Immunol. 2002; 14: 96-102. PMID: 11790538.
  • Sugiarto H, Yu PL. Avian antimicrobial peptides: the defense role of β-defensins. Biochem Biophys Res Commun. 2004; 323: 721-727. DOI: 10.1016/j.bbrc.2004.08.162.
  • Nguyen TX, Cole AM, Lehrer RI. Evolution of primate θ-defensins: a serpentine path to a sweet tooth. Peptides. 2003; 24: 1647-1654. DOI: 10.1016/j.peptides.2003.07.023.
  • Ganz T, Lehrer RI. Defensins. Pharmacol Ther. 1995; 66: 191-205. DOI: 10.1016/0163-7258(94)00076-F.
  • Stolzenberg ED, Anderson GM, Ackermann MR, Whitlock RH, Zasloff M. Epithelial antibiotic induced in states of disease. Proc Natl Acad Sci USA. 1997; 94: 8686-8690. PMCID: PMC23078.
  • Bahar AA, Ren D. Antimicrobial peptides. Pharmaceuticals. 2013; 6: 1543-1575. DOI:10.3390/ph6121543.
  • Ackermann MR, Gallup JM, Zabner J, Evans RB, Brockus CW, Meyerholz DK, Grubor B, Brogden KA. Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia. Microb Pathog. 2004; 37: 21-27. DOI: 10.1016/j.micpath.2004.04.003.
  • Jenssen H, Hamill P, Hancock REW. Peptide antimicrobial agents. Clin Microbiol Rev. 2006; 19: 491-511. DOI: 10.1128/CMR.00056-05.
  • Kaiser V, Diamond G. Expression of mammalian defensin genes. J Leukoc Biol. 2000; 68: 779-784. PMID: 11129644.
  • Patil A, Hughes AL, Zhang G. Rapid evolution and diversification of mammalian α-defensins as revealed by comparative analysis of rodent and primate genes. Physiol Genomics. 2004; 20: 1-11. PMID: 15494476.
  • Bruhn O, Regenhard P, Michalek M, Paul S, Gelhaus C, Jung S, Thaller G, Podschun R, Leippe M, Grotzinger J, Kalm E. A novel horse α-defensin: gene transcription, recombinant expression and characterization of the structure and function. Biochem J. 2007; 407: 267-276. DOI: 10.1042/BJ20070747.
  • Bruhn O, Grötzinger J, Cascorbi I, Jung S. Antimicrobial peptides and proteins of the horse - insights into a well-armed organism. BMC Vet Res. 2011; 42: 98.
  • Luenser K, Ludwig A. Variability and evolution of bovine β-defensin genes. Genes Immun. 2005; 6: 115-122. PMID: 15674371.
  • Münk C, Wei G, Yang OO, Waring AJ, Wang W, Hong T, Lehrer RI, Landau NR, Cole AM. The θ-defensin, retrocyclin, inhibits HIV-1 entry. AIDS Res Hum Retroviruses. 2003; 19: 875-881. PMID: 14585219.
  • Meade KG, Cormican P, Narciandi F, Lloyd A, O’Farrelly C. Bovine β-defensin gene family: opportunities to improve animal health? Physiol Genomics. 2014; 46: 17-28. PMID: 24220329.
  • Michailidis G, Argiriou A, Kalivas A, Avdi M, Pappa V. Expresyon of avian β-defensins in the chicken (Gallus domesticus) reproductive tract. Archiva Zootechnica. 2008; 11: 33-40.
  • Kościuczuk EM, Lisowski P, Jarczak J, Krzyżewski J, Zwierzchowski L, Bagnicka E. Expression patterns of β-defensin and cathelicidin genes in parenchyma of bovine mammary gland infected with coagulase-positive or coagulase-negative Staphylococci. BMC Vet Res. 2014; 10: 246. DOI: 10.1186/s12917-014-0246-z.
  • Wojdak-Maksymiec K, Strabel T, Szyda J, Mikolajczyk K. Clinical mastitis and combined defensin polymorphism in dairy cattle. J Anim Vet Adv. 2012; 11: 2230-2237. DOI: 10.3923/javaa.2012.2230.2237.
  • Swanson K, Gorodetsky S, Good L, Davis S, Musgrave D, Stelwagen K, Farr V, Molenaar A. Expression of a β-defensin mRNA, lingual antimicrobial peptide, in bovine mammary epithelial tissue is induced by mastitis. Infect Immun. 2004; 72: 7311-7314. DOI: 10.1128/IAI.72.12.7311–7314.2004.
  • Whelehan CJ, Meade KG, Eckersall PD, Young FJ, O’Farrelly C. Experimental Staphylococcus aureus infection of the mammary gland induces region-specific changes in innate immune gene expression. Vet Immunol Immunopathol. 2011; 140: 181-189. DOI: 10.1016/j.vetimm.2010.11.013.
  • Brogden KA, Ackermann M, McCray PB Jr, Tack BF. Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents. 2003; 22: 465-478. DOI: 10.1016/S0924-8579(03)00180-8.
  • McDermott AM. Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf. 2004; 2: 229-247. PMID: 17216098.
  • Aono S, Li C, Zhang G, Kemppainen RJ, Gard J, Lu W, Hu X, Schwartz DD, Morrison EE, Dykstra C, Shi J. Molecular and functional characterization of bovine β-defensin-1. Vet Immunol Immunopathol. 2006; 113: 181-190. DOI: 10.1016/j.vetimm.2006.05.002.
  • Wu J, Wang C, He H, Hu G, Yang H, Gao Y, Zhong J. Molecular analysis and recombinant expression of bovine neutrophil β-defensin 12 and its antimicrobial activity. Mol Biol Rep. 2011; 38: 429-436. DOI: 10.1007/s11033-010-0125-z.
  • Yount NY, Yuan J, Tarver A, Castro T, Diamond G, Tran PA, Levy JN, McCulloughi C, Cullori JS, Bevins CL, Selsted ME. Cloning and expression of bovine neutrophil β-defensins. Biosynthetic profile during neutrophilic maturation and localization of mature peptide to novel cytoplasmic dense granules. J Biol Chem. 1999; 274: 26249-26258. DOI: 10.1074/jbc.274.37.26249.
  • Narciandi F, Lloyd AT, Chapwanya A, O’ Farrelly C, Meade KG. Reproductive tissue-specific expression profiling and genetic variation across a 19 gene bovine β-defensin cluster. Immunogenetics. 2011; 63: 641-651. DOI: 10.1007/s00251-011-0551-7.
  • Huttner KM, Brezinski-Caliguri DJ, Mahoney MM, Diamond G. Antimicrobial peptide expression is developmentally regulated in the ovine gastrointestinal tract. J Nutr. 1998; 128: 297S-299S.
  • Luenser K, Fickel J, Ludwig A. Evolution of caprine and ovine β-defensin genes. Immunogenetics. 2005; 57: 487-498. PMID: 16133452.
  • Zhao C, Nguyen T, Lıu L, Shamova O, Brogden K, Lehrer RI. Differential expression of caprine β-defensins in digestive and respiratory tissues. Infect Immun. 1999; 67: 6221-6224.
  • Meade KG, Higgs R, Lloyd AT, Giles S, O’Farrelly C. Differential antimicrobial peptide gene expression patterns during early chicken embryological development. Dev Comp Immunol. 2009; 33: 516-524. DOI: 10.1016/j.dci.2008.10.003.
  • van Dijk A, Veldhuizen EJA, Haagsman HP. Avian defensins. Vet Immunol Immunopathol. 2008; 124: 1-18. DOI: 10.1016/j.vetimm.2007.12.006.
  • Ma D, Lin L, Zhang K, Han Z, Shao Y, Liu X, Liu S. Three novel Anas platyrhynchos avian β-defensins, upregulated by duck hepatitis virus, with antibacterial and antiviral activities. Mol Immunol. 2011; 49: 84-96. DOI: 10.1016/j.molimm.2011.07.019.
  • Hervé-Grépinet V, Réhault-Godbert S, Labas V, Magallon T, Derache C, Lavergne M, Gautron J, Lalmanach AC, Nys Y. Purification and characterization of avian β-defensin 11, an antimicrobial peptide of the hen egg. Antimicrob Agents Chemother. 2010; 54: 4401-4409. DOI: 10.1128/AAC.00204-10.
  • Gong D, Wilson PW, Bain MM, McDade K, Kalina J, Hervé-Grépinet V, Nys Y, Dunn IC. Gallin; an antimicrobial peptide member of a new avian defensin family, the ovodefensins, has been subject to recent gene duplication. BMC Immunol. 2010; 11: 1-15. PMID: 20226050.
  • Jin JY, Zhou L, Wang Y, Li Z, Zhao JG, Zhang QY, Gui JF. Antibacterial and antiviral roles of a fish β-defensin expressed both in pituitary and testis. PLoS ONE. 2010; 5: e12883. DOI: 10.1371/journal.pone.0012883.
  • Johnson GP, Lloyd AT, O’Farrelly C, Meade KG, Fair S. Comparative genomic identification and expression profiling of a novel β-defensin gene cluster in the equine reproductive tract. Reprod Fertil Dev. 2015. DOI: 10.1071/RD14345.
  • Linde A, Ross CR, Davis EG, Dib L, Blecha F, Melgarejo T. Innate immunity and host defense peptides in veterinary medicine. J Vet Intern Med. 2008; 22: 247-265. DOI: 10.1111/j.1939-1676.2007.0038.x.
  • Maxwell AI, Morrison GM, Dorin JR. Rapid sequence divergence in mammalian β-defensins by adaptive evolution. Mol Immunol. 2003; 40: 413-421. DOI: 10.1016/S0161-5890(03)00160-3.
  • Davis EG, Sang Y, Blecha F. Equine β-defensin-1: full-length cDNA sequence and tissue expression. Vet Immunol Immunopathol. 2004; 99: 127-132. DOI: 10.1016/j.vetimm.2003.12.010.
  • van Damme CM, Willemse T, van Dijk A, Haagsman HP, Veldhuizen EJ. Altered cutaneous expression of β-defensins in dogs with atopic dermatitis. Mol immunol. 2009; 46: 2449-2455. DOI: 10.1016/j.molimm.2009.05.028.
  • Hussain S, Mukhopadhyay CS, Arora JS. Applications and implications of mammalian antimicrobial peptides- a review. Agri Review. 2014; 35: 299-306.
  • Yasin B, Wang W, Pang M, Cheshenko N, Hong T, Waring AJ, Herold BC, Wagar EA, Lehrer RI. θ-defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. J Virol. 2004; 78: 5147-5156. DOI: 10.1128/JVI.78.10.5147–5156.2004.
  • Xie GH, Chen QX, Cheng BL, Fang XM. Defensins and sepsis. Biomed Res Int. 2014. DOI: 10.1155/2014/180109.
  • Ma D, Zhang K, Zhang M, Xin S, Liu X, Han Z, Shao Y, Liu S. Identification, expression and activity analyses of five novel duck beta-defensins. PLoS ONE. 2012; 7: e47743. DOI: 10.1016/j.cimid.2012.01.006.
  • Wiens ME, Wilson SS, Lucero CM, Smith JG. Defensins and viral infection: dispelling common misconceptions. PLoS Pathog. 2014; 10: e1004186. DOI: 10.1371/journal.ppat.1004186.
  • Erles K, Brownlie J. Expression of β-defensins in the canine respiratory tract and antimicrobial activity against Bordetella bronchiseptica. Vet Immunol Immunopathol. 2010; 135: 12-19. DOI: 10.1016/j.vetimm.2009.10.025.
  • Leonard BC, Marks SL, Outerbridge CA, Affolter VK, Kananurak A, Young A, Moore PF, Bannasch DL, Bevins CL. Activity, expression and genetic variation of canine β-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs. J Innate Immun. 2012; 4: 248-259. DOI: 10.1159/000334566.
  • Zhang G, Sunkara LT. Avian antimicrobial host defense peptides: from biology to therapeutic applications. Pharmaceuticals. 2014; 7: 220-247. DOI: 10.3390/ph7030220.
  • Mor A. Multifunctional host defense peptides: antiparasitic activities. FEBS J. 2009; 276: 6474-6482. DOI: 10.1111/j.1742-4658.2009.07358.x.
  • Yeaman MR, Yount NY. Mechanisms of antimicrobial peptide action and resistance. Pharmacol Rev. 2003; 55: 27-55. DOI: 10.1124/pr.55.1.2.
  • Mitchell GB, Al-Haddawi MH, Clark ME, Beveridge JD, Caswell JL. Effect of corticosteroids and neuropeptides on the expression of defensins in bovine tracheal epithelial cells. Infect Immun. 2007; 75: 1325-1334. DOI: 10.1128/IAI.00686-06.
  • Schukken YH, Günther J, Fitzpatrick J, Fontaine MC, Goetze L, Holst O, Leigh J, Petzl W, Schuberth HJ, Sipka A, Smith DGE, Quesnelld R, Watts J, Yancey R, Zerbe H, Gurjar A, Zadoks RN, Seyfert HM, members of the Pfizer mastitis research consortium. Host-response patterns of intramammary infections in dairy cows. Vet Immunol Immunopathol. 2011; 144: 270-289. DOI: 10.1016/j.vetimm.2011.08.022.
  • Rainard P, Riollet C. Innate immunity of the bovine mammary gland. Vet Res. 2006: 37; 369-400. DOI: 10.1051/vetres:2006007.
  • Cézard C, Silva-Pires V, Mullié C, Sonnet P. Antibacterial peptides: A rewiew. In: Méndez-Vilas A, editör(s). Science Against Pathogens: Communicating Current Research and Technological Advances.
  • Microbiology Series No 3, Vol 1, p: 926-937, Formatex, Spain, 2011.
  • Oviedo-Boyso J, Valdes-Alarcón JJ, Cajero-Juárez M, Ochoa-Zarzosa A, López-Meza JE, Bravo-Patiño A, Baizabal-Aguirre VM. Innate immune response of bovine mammary gland to pathogenic bacteria responsible for mastitis. J Infect. 2007; 54: 399-409. DOI: 10.1016/j.jinf.2006.06.010.
  • Yarus S, Rosen JM, Cole AM, Diamond G. Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice. Proc Natl Acad Sci USA. 1996; 93: 14118-14121.
Journal Section Reviews
Authors

Author: Ezgi ŞABABOĞLU

Author: Hülya TÜRÜTOĞLU

Dates

Publication Date: June 23, 2016

Bibtex @ { maeuvfd260788, journal = {Veterinary Journal of Mehmet Akif Ersoy University}, issn = {2458-9268}, eissn = {2148-6239}, address = {Mehmet Akif Ersoy University}, year = {2016}, volume = {1}, pages = {29 - 39}, doi = {10.24880/maeuvfd.260788}, title = {HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ}, key = {cite}, author = {ŞABABOĞLU, Ezgi and TÜRÜTOĞLU, Hülya} }
APA ŞABABOĞLU, E , TÜRÜTOĞLU, H . (2016). HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ. Veterinary Journal of Mehmet Akif Ersoy University, 1 (1), 29-39. DOI: 10.24880/maeuvfd.260788
MLA ŞABABOĞLU, E , TÜRÜTOĞLU, H . "HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ". Veterinary Journal of Mehmet Akif Ersoy University 1 (2016): 29-39 <http://dergipark.org.tr/maeuvfd/issue/24656/260788>
Chicago ŞABABOĞLU, E , TÜRÜTOĞLU, H . "HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ". Veterinary Journal of Mehmet Akif Ersoy University 1 (2016): 29-39
RIS TY - JOUR T1 - HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ AU - Ezgi ŞABABOĞLU , Hülya TÜRÜTOĞLU Y1 - 2016 PY - 2016 N1 - doi: 10.24880/maeuvfd.260788 DO - 10.24880/maeuvfd.260788 T2 - Veterinary Journal of Mehmet Akif Ersoy University JF - Journal JO - JOR SP - 29 EP - 39 VL - 1 IS - 1 SN - 2458-9268-2148-6239 M3 - doi: 10.24880/maeuvfd.260788 UR - https://doi.org/10.24880/maeuvfd.260788 Y2 - 2019 ER -
EndNote %0 Veterinary Journal of Mehmet Akif Ersoy University HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ %A Ezgi ŞABABOĞLU , Hülya TÜRÜTOĞLU %T HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ %D 2016 %J Veterinary Journal of Mehmet Akif Ersoy University %P 2458-9268-2148-6239 %V 1 %N 1 %R doi: 10.24880/maeuvfd.260788 %U 10.24880/maeuvfd.260788
ISNAD ŞABABOĞLU, Ezgi , TÜRÜTOĞLU, Hülya . "HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ". Veterinary Journal of Mehmet Akif Ersoy University 1 / 1 (June 2016): 29-39. https://doi.org/10.24880/maeuvfd.260788
AMA ŞABABOĞLU E , TÜRÜTOĞLU H . HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ. MAEU Vet. Fak. Derg.. 2016; 1(1): 29-39.
Vancouver ŞABABOĞLU E , TÜRÜTOĞLU H . HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ. Veterinary Journal of Mehmet Akif Ersoy University. 2016; 1(1): 39-29.