Year 2019, Volume 32, Issue 1, Pages 1 - 6 2019-01-29

Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome
Polikistik over sendromunda insülin rezistansı ve nöropeptid Y düzeyleri arasındaki ilişkinin araştırılması

Tolga KOSECI [1] , Omer KAYA [2] , Veysel HAKSOYLER [3] , Didem DERICI YILDIRIM [4] , Kerem SEZER [5]

195 293

Objective: The aim of study is to investigate the relationship between neuropeptide Y (NPY) and insulin resistance which is important in the pathogenesis of poliycstic ovary syndrome (PCOS). Material and Methods: This study was conducted between May 2012 and May 2013. The study included 45 patients with PCOS and 44 healthy controls at productive age. Insulin, fasting blood sugar, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactine, testestorone, dehydroepiandrosterone sulfate (DHEA-S), thyroid stimulating hormone (TSH), cortisole, estradiol, NPY levels were measured at early follicular phase in patients with PCOS while insulin, fasting blood sugar, prolactine, DHEA-S, TSH, cortisole, 17-OH progesterone levels were measured in control group. Homeostatic model assessment for insulin resistance (HOMA-IR) scores were calculated and antrepometric measures recorded. Pelvic ultrasonography was performed. Results: Fasting insulin levels and HOMA-IR scores showed insulin resistance to be higher in obese patients with PCOS than healthy control subjects and patients with normal weight PCOS. NPY levels found to be higher in obese-overweight patients with PCOS than healthy control subjects and patients with normal weight but it was not statistically significant (P>0.05). NPY levels did not differ in patients with and without insulin resistance. Conclusion: No correlation dedected between insülin resistance and NPY levels but NPY levels were high in overweight PCOS patients.

Amaç: Çalışmanın amacı, polikistik over sendromu (PKOS)

patogenezinde önemli yeri olan nöropeptid Y (NPY) ve insülin

direnci arasındaki ilişkinin araştırılmasıdır.

Gereçler ve Yöntemler: Bu çalışma Mayıs 2012 ve Mayıs 2013

tarihleri arasında yapılmıştır. Çalışmaya doğurganlık çağındaki 45

PKOS hastası ve 44 sağlıklı kontrol grubu dahil edilmiştir. PKOS

grubuna erken foliküler fazda insulin, açlık kan şekeri, folikül

stimüle edici hormon (FSH), luteize edici hormon (LH), prolaktin,

testesteron, dehidroepiandrosteron sülfat (DHEA-S), tiroid

stimüle edici hormon (TSH), kortizol, östrodiol ve NPY düzeyleri

bakılırken, kontrol grubuna insülin, açlık kan şekeri, prolaktin,

DHEA-S, TSH, kortizol, 17-OH progesteron düzeyleri incelendi.

Homeostatik model insulin direnci değerlendirme (HOMA-IR)

testi skorları hesaplandı ve antropometrik ölçümler kaydedildi.

Pelvik ultrasonografi yapıldı.

Bulgular: İnsulin direncini gösteren açlık kan insülin düzeyi

ve HOMA-IR skoru, obez PKOS grubunda normal kilolu PKOS

ve kontrol grubuna göre yüksek bulundu. NPY düzeyleri obezyüksek

kilolu PKOS grubunda normal kilolu PKOS ve kontrol

grubuna göre yüksek bulundu ancak istatistiksel olarak anlamlı

değildi (P>0,05). NPY düzeyleri insülin rezistansı olan ve olmayan

hastalar arasında değişiklik göstermedi.

Sonuç: İnsülin rezistansı ve NPY düzeyleri arasında

korelasyon saptanmadı ancak NPY düzeyleri, kilolu PCOS

hastalarında yüksekti.

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Primary Language en
Subjects Medicine
Journal Section Articles
Authors

Author: Tolga KOSECI

Author: Omer KAYA (Primary Author)

Author: Veysel HAKSOYLER

Author: Didem DERICI YILDIRIM

Author: Kerem SEZER

Dates

Publication Date: January 29, 2019

Bibtex @research article { marumj500032, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {Marmara University}, year = {2019}, volume = {32}, pages = {1 - 6}, doi = {10.5472/marumj.500032}, title = {Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome}, key = {cite}, author = {KOSECI, Tolga and KAYA, Omer and HAKSOYLER, Veysel and DERICI YILDIRIM, Didem and SEZER, Kerem} }
APA KOSECI, T , KAYA, O , HAKSOYLER, V , DERICI YILDIRIM, D , SEZER, K . (2019). Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome. Marmara Medical Journal, 32 (1), 1-6. DOI: 10.5472/marumj.500032
MLA KOSECI, T , KAYA, O , HAKSOYLER, V , DERICI YILDIRIM, D , SEZER, K . "Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome". Marmara Medical Journal 32 (2019): 1-6 <http://dergipark.org.tr/marumj/issue/42918/500032>
Chicago KOSECI, T , KAYA, O , HAKSOYLER, V , DERICI YILDIRIM, D , SEZER, K . "Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome". Marmara Medical Journal 32 (2019): 1-6
RIS TY - JOUR T1 - Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome AU - Tolga KOSECI , Omer KAYA , Veysel HAKSOYLER , Didem DERICI YILDIRIM , Kerem SEZER Y1 - 2019 PY - 2019 N1 - doi: 10.5472/marumj.500032 DO - 10.5472/marumj.500032 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 1 EP - 6 VL - 32 IS - 1 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/marumj.500032 UR - https://doi.org/10.5472/marumj.500032 Y2 - 2018 ER -
EndNote %0 Marmara Medical Journal Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome %A Tolga KOSECI , Omer KAYA , Veysel HAKSOYLER , Didem DERICI YILDIRIM , Kerem SEZER %T Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome %D 2019 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 32 %N 1 %R doi: 10.5472/marumj.500032 %U 10.5472/marumj.500032
ISNAD KOSECI, Tolga , KAYA, Omer , HAKSOYLER, Veysel , DERICI YILDIRIM, Didem , SEZER, Kerem . "Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome". Marmara Medical Journal 32 / 1 (January 2019): 1-6. https://doi.org/10.5472/marumj.500032
AMA KOSECI T , KAYA O , HAKSOYLER V , DERICI YILDIRIM D , SEZER K . Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome. Marmara Med J. 2019; 32(1): 1-6.
Vancouver KOSECI T , KAYA O , HAKSOYLER V , DERICI YILDIRIM D , SEZER K . Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome. Marmara Medical Journal. 2019; 32(1): 6-1.