Kitle oluşturarak Hodgkin lenfomayı taklit eden ekstramedüller hematopoez olgusu

Yıl 2019, Cilt: 32 Sayı: 1, 55 - 57, 29.01.2019

Faruk Erdem Kombak Süheyla Uyar Bozkurt Toluy Özgümüş İşık Kaygusuz Atagündüz

https://doi.org/10.5472/marumj.518989

Öz

Ekstramedüller hematopoez (EMH), hematopoetik öncül

hücrelerin kemik iliği dışında çoğalması olarak tanımlanmaktadır.

EMH, vücudun farklı bölgelerinde kitlesel lezyon olarak karşımıza

çıkabilmektedir. Bu olgu sunumunda; ayırıcı tanı, bir tanı hatası ve

olası tuzaklar üzerinden irdelenmektedir.

Anahtar Kelimeler

Ekstramedüller hematopoez, Arka mediasten kitlesi, Hemolitik anemi

Mass-forming extramedullary hematopoiesis mimicking Hodgkin’s lymphoma

Öz

Extramedullary hematopoiesis (EMH) refers to the proliferation

of hematopoietic precursors outside the bone marrow. EMH often

presents as a mass lesion in several areas of the body. In this

report, we present a case misdiagnosed and explain the cause of

the diagnostic error.

Anahtar Kelimeler

Extramedullary hematopoiesis, Posterior mediastinal mass, Hemolytic anemia

Kaynakça

• 1. Yamamoto K, Miwa Y, Abe-Suzuki S, et al. Extramedullary hematopoiesis: Elucidating the function of the hematopoietic stem cell niche (Review). Mol Med Rep 2016;13:587-91. doi: 10.3892/mmr.2015.4621.
• 2. Solazzo A, D’Auria V, Moccia LG, Vatrella A, Bocchino M, Rea G. Posterior mediastinal extramedullary hematopoiesis secondary to hypoxia. Transl Med UniSa 2016;14:1-4.
• 3. Koch M, Kurian EM. Pleural fluid extramedullary hematopoiesis case report with review of the literature. Diagn Cytopathol 2016;44:41-4. doi: 10.1002/dc.23390.
• 4. Mahadevan NR, Morgan EA, Mitchell RN. Case report and literature review: cardiac tamponade as a complication of pericardial extramedullary hematopoiesis. Cardiovasc Pathol 2016;25:371-4. doi: 10.1016/j.carpath.2016.05.007.
• 5. Sekar S, Burad D, Abraham A, Paul MJ. Adrenal incidentaloma caused by extramedullary haematopoiesis: conservative management is optimal. BMJ Case Rep 2015;2015. doi: 10.1136/bcr-2015-211014.
• 6. Humphrey PA, Vollmer RT. Extramedullary hematopoiesis in the prostate. Am J Surg Pathol 1991;15:486-90.
• 7. Khuraijam B, Sobti P, Shangpliang D, Khurana N. Extramedullary haematopoiesis in a case of pilomatricoma. JClin Diagn Res 2016;10:ED17-ED18. doi: 10.7860/ JCDR/2016/18947.8068
• 8. Ohta Y, Shichinohe H, Nagashima K. Spinal cord compression due to extramedullary hematopoiesis associated with polycythemia vera—case report. Neurol Med Chir 2002;42:40-3.
• 9. Pornsuriyasak P, Suwatanapongched T, Wangsuppasawad N, Ngodngamthaweesuk M, Angchaisuksiri P. Massive hemothorax in a beta-thalassemic patient due to spontaneous rupture of extramedullary hematopoietic masses: diagnosis and successful treatment. Respir Care 2006;51:272-6.
• 10. Tsitouridis J, Stamos S, Hassapopoulou E, Tsitouridis K, Nikolopoulos P. Extramedullary paraspinal hematopoiesis in thalassemia: CT and MRI evaluation. Eur J Radiol 1999;30:33-8.
• 11. Bowling MR, Cauthen CG, Perry CD, et al. Pulmonary extramedullary hematopoiesis. J Thorac Imaging 2008;23:138-41. doi: 10.1097/RTI.0b013e31815b89aa.
• 12. Orphanidou-Vlachou E, Tziakouri-Shiakalli C, Georgiades CS. Extramedullary hemopoiesis. Semin Ultrasound, CT, MR 2014;35:255-62.
• 13. Nakayama F, Nishihara S, Iwasaki H, et al. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. J Biol Chem 2001;276:16100-6.
• 14. Sheibani K, Battifora H, Burke JS, Rappaport H. Leu-M1 antigen in human neoplasms. An immunohistologic study of 400 cases. Am J Surg Pathol 1986;10:227-36.
• 15. Swerdlow SH, Wright SA. The spectrum of Leu-M1 staining in lymphoid and hematopoietic proliferations. Am J Clin Pathol 1986 ;85:283-8.
• 16. Pinkus GS, Said JW. Leu-M1 immunoreactivity in nonhematopoietic neoplasms and myeloproliferative disorders. An immunoperoxidase study of paraffin sections. Am J Clin Pathol 1986;85:278-82.
• 17. Hall PA, D’Ardenne AJ. Value of CD15 immunostaining in diagnosing Hodgkin’s disease: a review of published literature. JClin Pathol 1987 ;40:1298-304.