Year 2018, Volume 8, Issue 3, Pages 175 - 181 2018-09-28

Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils

Zarife Nigâr Özdemir-Kumral [1] , Ahmet Cumhur [2] , Ali İhsan Oluk [3] , Aykut Hoşcan [4] , İdris Önem [5] , Gazi Contuk [6] , Feriha Ercan [7] , Berrak Yeğen [8]

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Purpose: Protective effects of nesfatin-1 was studied in sepsis-induced injury of

remote organs.

Methods: Male rats were randomly divided as control and sepsis (cecal ligationperforation)

groups, treated with either saline or nesfatin-1 (10 μg/kg). At 16 h

following surgery, samples of brain, kidney, liver and lung tissues were removed

and myeloperoxidase (MPO) activity, glutathione (GSH), catalase (CAT), superoxide

dismutase (SOD) and malondialdehyde (MDA) levels were measured in these

tissues.

Results: In saline-treated septic rats, elevated MDA and MPO activities were

accompanied with depleted CAT, SOD and GSH levels in the brain, kidney, liver

and lung tissues, implicating extensive oxidative damage in all remote organs.

Nesfatin-1 reduced MDA levels (brain, lung) and MPO activities (brain, kidney),

and preserved antioxidant GSH (brain, lung), CAT (brain) and SOD (kidney) levels.

Severe hepatocyte degeneration, neuronal damage, glomerulotubular degeneration

and alveolar disturbance in saline-treated septic rats were replaced with regular tissue

morphologies in nesfatin-1-treated rats.

Conclusion: Nesfatin-1 alleviates oxidative damage by enhancing endogenous

antioxidant systems and inhibiting recruitment of neutrophils, suggesting that

nesfatin-1 may be have a potential therapeutic impact on the treatment of septic

shock to reduce subsequent remote organ failure.

Sepsis, CLP, Nesfatin-1, oxidative stress
  • Lever A, Mackenzie I: Sepsis: definition, epidemiology, and diagnosis. BMJ 2007; 335(7625):879-83.
Primary Language en
Subjects Health Care Sciences and Services
Journal Section Articles
Authors

Author: Zarife Nigâr Özdemir-Kumral

Author: Ahmet Cumhur

Author: Ali İhsan Oluk

Author: Aykut Hoşcan

Author: İdris Önem

Author: Gazi Contuk

Author: Feriha Ercan

Author: Berrak Yeğen

Dates

Publication Date: September 28, 2018

Bibtex @research article { marusbed465485, journal = {Clinical and Experimental Health Sciences}, issn = {}, eissn = {2459-1459}, address = {Marmara University}, year = {2018}, volume = {8}, pages = {175 - 181}, doi = {10.5152/clinexphealthsci.2017.606}, title = {Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils}, key = {cite}, author = {Özdemir-Kumral, Zarife Nigâr and Cumhur, Ahmet and Oluk, Ali İhsan and Hoşcan, Aykut and Önem, İdris and Contuk, Gazi and Ercan, Feriha and Yeğen, Berrak} }
APA Özdemir-Kumral, Z , Cumhur, A , Oluk, A , Hoşcan, A , Önem, İ , Contuk, G , Ercan, F , Yeğen, B . (2018). Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils. Clinical and Experimental Health Sciences, 8 (3), 175-181. DOI: 10.5152/clinexphealthsci.2017.606
MLA Özdemir-Kumral, Z , Cumhur, A , Oluk, A , Hoşcan, A , Önem, İ , Contuk, G , Ercan, F , Yeğen, B . "Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils". Clinical and Experimental Health Sciences 8 (2018): 175-181 <http://dergipark.org.tr/marusbed/issue/39474/465485>
Chicago Özdemir-Kumral, Z , Cumhur, A , Oluk, A , Hoşcan, A , Önem, İ , Contuk, G , Ercan, F , Yeğen, B . "Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils". Clinical and Experimental Health Sciences 8 (2018): 175-181
RIS TY - JOUR T1 - Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils AU - Zarife Nigâr Özdemir-Kumral , Ahmet Cumhur , Ali İhsan Oluk , Aykut Hoşcan , İdris Önem , Gazi Contuk , Feriha Ercan , Berrak Yeğen Y1 - 2018 PY - 2018 N1 - doi: 10.5152/clinexphealthsci.2017.606 DO - 10.5152/clinexphealthsci.2017.606 T2 - Clinical and Experimental Health Sciences JF - Journal JO - JOR SP - 175 EP - 181 VL - 8 IS - 3 SN - -2459-1459 M3 - doi: 10.5152/clinexphealthsci.2017.606 UR - https://doi.org/10.5152/clinexphealthsci.2017.606 Y2 - 2019 ER -
EndNote %0 Clinical and Experimental Health Sciences Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils %A Zarife Nigâr Özdemir-Kumral , Ahmet Cumhur , Ali İhsan Oluk , Aykut Hoşcan , İdris Önem , Gazi Contuk , Feriha Ercan , Berrak Yeğen %T Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils %D 2018 %J Clinical and Experimental Health Sciences %P -2459-1459 %V 8 %N 3 %R doi: 10.5152/clinexphealthsci.2017.606 %U 10.5152/clinexphealthsci.2017.606
ISNAD Özdemir-Kumral, Zarife Nigâr , Cumhur, Ahmet , Oluk, Ali İhsan , Hoşcan, Aykut , Önem, İdris , Contuk, Gazi , Ercan, Feriha , Yeğen, Berrak . "Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils". Clinical and Experimental Health Sciences 8 / 3 (September 2018): 175-181. https://doi.org/10.5152/clinexphealthsci.2017.606
AMA Özdemir-Kumral Z , Cumhur A , Oluk A , Hoşcan A , Önem İ , Contuk G , Ercan F , Yeğen B . Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils. Clinical and Experimental Health Sciences. 2018; 8(3): 175-181.
Vancouver Özdemir-Kumral Z , Cumhur A , Oluk A , Hoşcan A , Önem İ , Contuk G , Ercan F , Yeğen B . Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils. Clinical and Experimental Health Sciences. 2018; 8(3): 181-175.