Year 2018, Volume 8, Issue 3, Pages 196 - 201 2018-09-28

Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain

Erkan Kilinc [1] , Yasar Dagistan [2] , Fatma Tore [3]

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Objective: The cranial dura mater contains plenty of mast cells and is principally

supplied by the middle meningeal artery which has a key role in the generation of

headaches. Neurogenic inflammation caused by perivascular nerve activation and

dural vasodilation is held responsible for migraine pain. Dural mast cells contribute

neurogenic inflammation and migraine via vasoactive and proinflammatory mediators

in their secretory granules. In the present study, it was aimed to investigate vasoactive

effect of mast cell degranulating agent compound 48/80 induced dural mast cell

degranulation on the middle meningeal artery and its anterior and posterior branches.

Methods: Isolated skulls obtained from male Wistar rats were divided into 2 halves.

The skull cavities with intact the dura mater were applied synthetic interstitial fluid

for control group or mast cell degranulating agent compound 48/80 (10 μg/ml) in

synthetic interstitial fluid for treated group at 37 oC for 15 min. Diameters of middle

meningeal artery and its anterior and posterior branches were measured and mast

cells were counted from whole-mount preparations of meningeal dura mater.

Results: While compound 48/80 induced massive degranulation of dural mast cells

(P<0.01), it did not change the number of mast cells in the dura mater. Moreover,

compound 48/80 increased diameter of middle meningeal artery (P<0.01) and

its anterior (P<0.05) and posterior (P<0.01) branches, respectively compared to

synthetic interstitial fluid treatment.

Conclusion: Dural mast cell degranulation causes dilatation of middle meningeal

artery which is involved in the pathophysiology of migraine, therefore testing of mast

cell stabilizing agents in vivo models of migraine pain may promise hope for the next

big things in the treatment of migraine headaches.

Migraine, meningeal artery, dural mast cell, neurogenic inflammation
  • Moskowitz MA. The visceral organ brain Implications for the pathophysiology of vascular head pain. Neurology 1991; 41: 182-86.
Primary Language en
Journal Section Articles
Authors

Author: Erkan Kilinc

Author: Yasar Dagistan

Author: Fatma Tore

Dates

Publication Date: September 28, 2018

Bibtex @research article { marusbed465489, journal = {Clinical and Experimental Health Sciences}, issn = {}, eissn = {2459-1459}, address = {Marmara University}, year = {2018}, volume = {8}, pages = {196 - 201}, doi = {}, title = {Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain}, key = {cite}, author = {Kilinc, Erkan and Dagistan, Yasar and Tore, Fatma} }
APA Kilinc, E , Dagistan, Y , Tore, F . (2018). Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. Clinical and Experimental Health Sciences, 8 (3), 196-201. Retrieved from http://dergipark.org.tr/marusbed/issue/39474/465489
MLA Kilinc, E , Dagistan, Y , Tore, F . "Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain". Clinical and Experimental Health Sciences 8 (2018): 196-201 <http://dergipark.org.tr/marusbed/issue/39474/465489>
Chicago Kilinc, E , Dagistan, Y , Tore, F . "Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain". Clinical and Experimental Health Sciences 8 (2018): 196-201
RIS TY - JOUR T1 - Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain AU - Erkan Kilinc , Yasar Dagistan , Fatma Tore Y1 - 2018 PY - 2018 N1 - DO - T2 - Clinical and Experimental Health Sciences JF - Journal JO - JOR SP - 196 EP - 201 VL - 8 IS - 3 SN - -2459-1459 M3 - UR - Y2 - 2019 ER -
EndNote %0 Clinical and Experimental Health Sciences Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain %A Erkan Kilinc , Yasar Dagistan , Fatma Tore %T Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain %D 2018 %J Clinical and Experimental Health Sciences %P -2459-1459 %V 8 %N 3 %R %U
ISNAD Kilinc, Erkan , Dagistan, Yasar , Tore, Fatma . "Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain". Clinical and Experimental Health Sciences 8 / 3 (September 2018): 196-201.
AMA Kilinc E , Dagistan Y , Tore F . Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. Clinical and Experimental Health Sciences. 2018; 8(3): 196-201.
Vancouver Kilinc E , Dagistan Y , Tore F . Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. Clinical and Experimental Health Sciences. 2018; 8(3): 201-196.