Year 2018, Volume 8, Issue 3, Pages 211 - 216 2018-09-28

Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder

Esra Çikler Dülger [1] , Yasemin Ersoy Çanıllıoğlu [2] , Şule Çetinel [3] , Göksel Şener [4] , Feriha Ercan [5]

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Objective: The aim of the study was to investigate the role of montelukast (ML), a

cysteinyl leukotriene-1 receptor antagonist, on the water avoidance stress (WAS) –

induced degeneration of the rat urinary bladder mucosa.

Methods: In WAS group, rats were exposed to WAS two hours daily for five days.

In WAS+ML group, rats were administered ML (10 mg/kg; i.p.;) following every WAS

exposure for 5 days. In control group, rats were injected vehicle solution only. The

urinary bladder was evaluated for general morphology at light microscope. Mast

cell activation and uroplakin distribution were assassed with immunohistochemistry.

Glycosaminoglycan (GAG) distribution and urothelial permeability were observed

using ruthenium red (RR) staining techniques in transmission electron microscope

and luminal urothelial cells were observed with scanning electron microscope. Tissue

malondialdehyde (MDA) and gluthatione (GSH) levels were also analysed.

Results: Irregular GAG layer and uroplakin distribution, penetration of RR in

the intercellular spaces and dilated tight junctions in urothelial layer, increase in

inflammatory cell infiltration, in number of both granulated and activated mast cells,

and were observed in the WAS group. The MDA level was increased, and GSH level

was decreased significantly in urinary bladder in the WAS group in comparison with

the control group. Quite regular GAG layer, uroplakin distribution and tight junctions

in most regions, decrease in inflammatory cell infiltration and both of activated and

granulated mast cells in the mucosa, were observed in WAS+ML group. Moreover,

significant decrease in MDA and increase in GSH levels were observed in this group.

Conclusion: Montelukast appears to exert a protective activity in WAS induced

urinary bladder injury by inhibiting inflammatory and oxidative activity.

Water avoidance stress, montelukast, urinary bladder, uroplakin, mast cell
  • van de Merwe JP, Nordling J, Bouchelouche P, Bouchelouche K, Cervigni M, Daha LK, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008; 53(1):60-7.
Primary Language en
Subjects Health Care Sciences and Services
Journal Section Articles
Authors

Author: Esra Çikler Dülger

Author: Yasemin Ersoy Çanıllıoğlu

Author: Şule Çetinel

Author: Göksel Şener

Author: Feriha Ercan

Dates

Publication Date: September 28, 2018

Bibtex @research article { marusbed465496, journal = {Clinical and Experimental Health Sciences}, issn = {}, eissn = {2459-1459}, address = {Marmara University}, year = {2018}, volume = {8}, pages = {211 - 216}, doi = {10.5152/clinexphealthsci.2017.691}, title = {Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder}, key = {cite}, author = {Çikler Dülger, Esra and Ersoy Çanıllıoğlu, Yasemin and Çetinel, Şule and Şener, Göksel and Ercan, Feriha} }
APA Çikler Dülger, E , Ersoy Çanıllıoğlu, Y , Çetinel, Ş , Şener, G , Ercan, F . (2018). Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder. Clinical and Experimental Health Sciences, 8 (3), 211-216. DOI: 10.5152/clinexphealthsci.2017.691
MLA Çikler Dülger, E , Ersoy Çanıllıoğlu, Y , Çetinel, Ş , Şener, G , Ercan, F . "Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder". Clinical and Experimental Health Sciences 8 (2018): 211-216 <http://dergipark.org.tr/marusbed/issue/39474/465496>
Chicago Çikler Dülger, E , Ersoy Çanıllıoğlu, Y , Çetinel, Ş , Şener, G , Ercan, F . "Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder". Clinical and Experimental Health Sciences 8 (2018): 211-216
RIS TY - JOUR T1 - Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder AU - Esra Çikler Dülger , Yasemin Ersoy Çanıllıoğlu , Şule Çetinel , Göksel Şener , Feriha Ercan Y1 - 2018 PY - 2018 N1 - doi: 10.5152/clinexphealthsci.2017.691 DO - 10.5152/clinexphealthsci.2017.691 T2 - Clinical and Experimental Health Sciences JF - Journal JO - JOR SP - 211 EP - 216 VL - 8 IS - 3 SN - -2459-1459 M3 - doi: 10.5152/clinexphealthsci.2017.691 UR - https://doi.org/10.5152/clinexphealthsci.2017.691 Y2 - 2019 ER -
EndNote %0 Clinical and Experimental Health Sciences Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder %A Esra Çikler Dülger , Yasemin Ersoy Çanıllıoğlu , Şule Çetinel , Göksel Şener , Feriha Ercan %T Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder %D 2018 %J Clinical and Experimental Health Sciences %P -2459-1459 %V 8 %N 3 %R doi: 10.5152/clinexphealthsci.2017.691 %U 10.5152/clinexphealthsci.2017.691
ISNAD Çikler Dülger, Esra , Ersoy Çanıllıoğlu, Yasemin , Çetinel, Şule , Şener, Göksel , Ercan, Feriha . "Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder". Clinical and Experimental Health Sciences 8 / 3 (September 2018): 211-216. https://doi.org/10.5152/clinexphealthsci.2017.691
AMA Çikler Dülger E , Ersoy Çanıllıoğlu Y , Çetinel Ş , Şener G , Ercan F . Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder. Clinical and Experimental Health Sciences. 2018; 8(3): 211-216.
Vancouver Çikler Dülger E , Ersoy Çanıllıoğlu Y , Çetinel Ş , Şener G , Ercan F . Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder. Clinical and Experimental Health Sciences. 2018; 8(3): 216-211.