Year 2019, Volume 5, Issue 1, Pages 33 - 38 2019-04-28

Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit

Tuğba Cebeci [1] , Dilek Keskin [2] , Ahmet Ali Gökal [3]

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Objective: A retrospective analysis of the widely used antibiotics all susceptibility testing results from Escherichia coli (E. coli) cultured from clinical specimens private hospital (from January 2017 to November 2018) was performed.  

Methods: The VITEK 2 Compact automated microbiology system (bioMérieux) is designed for automated rapid antimicrobial susceptibility testing and identification of clinically relevant bacteria. Minimum inhibitory concentration (MIC) results previously obtained in recent clinical isolates with well-defined in isolates with well-characterized resistance mechanisms with the microdilution method were re-interpreted for the susceptible, intermediate and resistant categories using the 2018 EUCAST breakpoints. Clinical samples are most commonly isolated from blood, sputum and urine samples.  

Results: The results of resistance pattern of E. coli isolates in our locality to antimicrobial agents showed that the 64 E. coli strains tested against fifteen antimicrobial agents. E. coli isolates were highly resistant to piperacillin, ceftazidime and aztreonam 98%, 61% and 61% respectively. The most sensitive antibiotics were colistin, tigecycline, imipenem and meropenem. In the present study, 73% (47) of the isolates were resistant to at least three to fourteen antibiotics. All of the isolates showed resistance to at least one antibiotics. Thirty nine per cent of E. coli isolates were extended spectrum beta-lactamase (ESBL) producers.  

Conclusion: Considering the antibiogram, imipenem and meropenem should be preferred drugs for E. coli infection isolated from clinical samples.

Esherichia coli, antibiotic sensitivity, clinical specimens, intensive care unit
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Research articles
Authors

Orcid: 0000-0001-8960-0587
Author: Tuğba Cebeci (Primary Author)
Institution: Giresun University
Country: Turkey


Author: Dilek Keskin
Institution: ADNAN MENDERES UNIVERSITY
Country: Turkey


Author: Ahmet Ali Gökal
Institution: Özel Giresun Ada Hastanesi
Country: Turkey


Bibtex @research article { mbsjohs525833, journal = {Middle Black Sea Journal of Health Science}, issn = {}, eissn = {2149-7796}, address = {Ordu University}, year = {2019}, volume = {5}, pages = {33 - 38}, doi = {10.19127/mbsjohs.525833}, title = {Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit}, key = {cite}, author = {Cebeci, Tuğba and Keskin, Dilek and Gökal, Ahmet Ali} }
APA Cebeci, T , Keskin, D , Gökal, A . (2019). Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit. Middle Black Sea Journal of Health Science, 5 (1), 33-38. DOI: 10.19127/mbsjohs.525833
MLA Cebeci, T , Keskin, D , Gökal, A . "Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit". Middle Black Sea Journal of Health Science 5 (2019): 33-38 <http://dergipark.org.tr/mbsjohs/issue/44108/525833>
Chicago Cebeci, T , Keskin, D , Gökal, A . "Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit". Middle Black Sea Journal of Health Science 5 (2019): 33-38
RIS TY - JOUR T1 - Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit AU - Tuğba Cebeci , Dilek Keskin , Ahmet Ali Gökal Y1 - 2019 PY - 2019 N1 - doi: 10.19127/mbsjohs.525833 DO - 10.19127/mbsjohs.525833 T2 - Middle Black Sea Journal of Health Science JF - Journal JO - JOR SP - 33 EP - 38 VL - 5 IS - 1 SN - -2149-7796 M3 - doi: 10.19127/mbsjohs.525833 UR - https://doi.org/10.19127/mbsjohs.525833 Y2 - 2019 ER -
EndNote %0 Middle Black Sea Journal of Health Science Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit %A Tuğba Cebeci , Dilek Keskin , Ahmet Ali Gökal %T Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit %D 2019 %J Middle Black Sea Journal of Health Science %P -2149-7796 %V 5 %N 1 %R doi: 10.19127/mbsjohs.525833 %U 10.19127/mbsjohs.525833
ISNAD Cebeci, Tuğba , Keskin, Dilek , Gökal, Ahmet Ali . "Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit". Middle Black Sea Journal of Health Science 5 / 1 (April 2019): 33-38. https://doi.org/10.19127/mbsjohs.525833