Raynaud Fenomeni üzerine genetik yapı, östrojen ve toksik ajanların klinik etkileri

Yıl 2019, Cilt: 12 Sayı: 1, 143 - 149, 28.04.2019

Merih Akkapulu Ali Erdinç Yalın

https://doi.org/10.26559/mersinsbd.531295

Öz

Raynaud Fenomeni (RF) soğuk kaynaklı vazokonstrüksiyonla
karakterize bir hastalıktır. Bu güçlendirilmiş vazokonstrüksiyon, sempatik
sinir sistemi yoluyla soğumaya karşı bir refleks cevabı ve Alfa2C (α_2C)
adrenoreseptörlerinin lokal aktivasyonu ile gerçekleşmektedir. Bu hastalık
klinik olarak primer ve sekonder olarak sınıflandırılmaktadır. Primer RF
idiyopatiktir ve hastalığın en yaygın şeklidir. Sekonder RF, otoimmün veya
kanser gibi hastalıklara eşlik edebileceği gibi, sigara içimi ya da bazı
ilaçların kullanımı da sebebiyet verebilmektedir. Etkilenen bireyler, soğuk ve
stresin tetiklemesiyle birlikte, genellikle el parmaklarında, klasik üç renk
değişikliğiyle (solukluk, siyanoz ve hiperemi) ilişkili olan vazospastik
ataklardan muzdarip olmaktadırlar. Epidemiyolojik çalışmalardan elde edilen
veriler, RF prevalansı ile ilgili ilginç bulgular ortaya koymuştur. Yaşları
aynı olan kadınların, erkeklere göre anlamlı olarak daha yüksek bir insidansa
sahip olduğu belirlenmiştir. Bu derlemede, östrojenin, genetik yapının ve
kimyasal ajanların RF üzerine olan etkileri tartışılmıştır. Sonuç olarak, bu
hastalığa neden olan birçok faktör açıklanmasına rağmen, RF'nin başlangıcının
ve ilerlemesinin altında yatan moleküler mekanizmaların aydınlatılması için
daha fazla araştırmaya gereksinim duyulmaktadır.

Anahtar Kelimeler

Raynaud fenomeni, vazospazm, Alfa2(α2) adrenoreseptörler, östrojen

The clinical effects of genetic structure, estrogen, and toxic agents on Raynaud’s Phenomenon

Öz

Raynaud’s
phenomenon (RP) is characterized by cold-induced vasoconstriction. This
enhanced vasoconstriction is achieved by a reflex response to cooling through
the sympathetic nervous system and by local activation of Alpha2C (α_2C)
adrenoreceptors. This disease is clinically
classified as primary and secondary. Primary RP is idiopathic and is the most
common form of the disease. Secondary RP may be associated with diseases such
as autoimmune diseases or cancer, and smoking or the use of certain medications
may also be cause. Affected individuals suffer from vasospastic attacks
associated with classical three colour changes (paleness, cyanosis, and hyperemia), often triggered by cold
and/or stress. The data from the epidemiological studies revealed interesting
findings related to the prevalence of RP. 

It was determined that women with the same age had a
significantly higher incidence than men. In this review, the effects of
oestrogen, genetic structure and chemical agents on RP were discussed. As a
result, although many factors have been described causing this disease, further
research is needed to elucidate the molecular mechanisms underlying the onset
and progression of RP.

Anahtar Kelimeler

Raynaud's phenomenon, vasospasm, Alpha2 (α2) adrenoreceptors, estrogen

Kaynakça

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