Year 2017, Volume 5, Issue 1, Pages 413 - 418 2017-06-01

Genotoxic potentials of apigenin-7-O-glucoside and apigenin-7-O-rutinoside isolated from Mentha longifolia (L.) Huds. ssp. Longifolia
Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri

Selçuk Çeker [1] , Furkan Orhan [2] , Medine Güllüce [3] , Güleray Ağar [4]

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Particularly the chemicals in phenolic structure obtained from plants play an important role in preventing and eliminating the oxidative damage by inactivating the reactive oxygen species due to their antioxidant properties. However, today the structures of the most herbal products and their biological activities have not been illuminated adequately; studies on the toxicity of the many herbal antioxidants and damage to human health are also not investigated properly.  This study was designed to evaluate the genotoxic and anti- genotoxic effects of two phenolic compounds, Apigenin 7-O-glucoside (A7G) and Apigenin 7-O-rutinoside (A7R)  which are isolated from Mentha longifolia (L.) Huds. ssp. longifolia. The genotoxic and anti- genotoxic effects of two compounds in human lymphocytes cells were investigated by sister chromatid exchanges (SCEs) test system against aflatoxin B1 (AFB1). The results showed that A7G and A7R have strong anti-genotoxic properties.

Bitkilerden elde edilen, özellikle fenolik yapıdaki kimyasal maddeler, antioksidan özellikleri sayesinde reaktif oksijen türlerini inaktive ederek oksidatif hasarın önlenmesinde ve giderilmesinde önemli rol oynamaktadırlar. Buna karşın günümüzde, bitkisel ürünlerin çoğunun yapıları ve biyolojik etkinlikleri yeterince aydınlatılamamış olup, birçok bitkisel antioksidan maddenin toksisitesi ve insan sağlığına olan zararlarlarıyla ilgili çalışmalar yeterli değildir. Bu çalışma, Mentha longifolia L. Hudson ssp. longifolia bitkisinden izole edilen iki fenolik bileşik olan Apigenin-7-O-glikozit (A7G) ile Apigenin-7-O-rutinozit (A7R)’in genotoksik ve anti-genotoksik etkilerinin belirlenmesi üzerine tasarlanmıştır. İki fenolik bileşiğin, insan lenfosit hücrelerinde aflatoksin B1’e (AFB1) karşı genotoksik ve anti-genotoksik etkileri kardeş kromatid değişimi testi ile araştırılmıştır. Çalışma sonuçları A7G ve A7R’nin güçlü anti-genotoksik özelliklerinin olduğunu göstermiştir. 

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Subjects Engineering
Published Date Haziran 2017
Journal Section Makaleler
Authors

Author: Selçuk Çeker
Country: Turkey


Author: Furkan Orhan

Author: Medine Güllüce

Author: Güleray Ağar

Bibtex @research article { msufbd295598, journal = {Muş Alparslan Üniversitesi Fen Bilimleri Dergisi}, issn = {2147-7930}, eissn = {2149-6455}, address = {Mus Alparslan University}, year = {2017}, volume = {5}, pages = {413 - 418}, doi = {10.18586/msufbd.295598}, title = {Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri}, key = {cite}, author = {Çeker, Selçuk and Orhan, Furkan and Güllüce, Medine and Ağar, Güleray} }
APA Çeker, S , Orhan, F , Güllüce, M , Ağar, G . (2017). Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri. Muş Alparslan Üniversitesi Fen Bilimleri Dergisi, 5 (1), 413-418. DOI: 10.18586/msufbd.295598
MLA Çeker, S , Orhan, F , Güllüce, M , Ağar, G . "Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri". Muş Alparslan Üniversitesi Fen Bilimleri Dergisi 5 (2017): 413-418 <http://dergipark.org.tr/msufbd/issue/31841/295598>
Chicago Çeker, S , Orhan, F , Güllüce, M , Ağar, G . "Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri". Muş Alparslan Üniversitesi Fen Bilimleri Dergisi 5 (2017): 413-418
RIS TY - JOUR T1 - Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri AU - Selçuk Çeker , Furkan Orhan , Medine Güllüce , Güleray Ağar Y1 - 2017 PY - 2017 N1 - doi: 10.18586/msufbd.295598 DO - 10.18586/msufbd.295598 T2 - Muş Alparslan Üniversitesi Fen Bilimleri Dergisi JF - Journal JO - JOR SP - 413 EP - 418 VL - 5 IS - 1 SN - 2147-7930-2149-6455 M3 - doi: 10.18586/msufbd.295598 UR - https://doi.org/10.18586/msufbd.295598 Y2 - 2017 ER -
EndNote %0 Mus Alparslan University Journal of Science Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri %A Selçuk Çeker , Furkan Orhan , Medine Güllüce , Güleray Ağar %T Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri %D 2017 %J Muş Alparslan Üniversitesi Fen Bilimleri Dergisi %P 2147-7930-2149-6455 %V 5 %N 1 %R doi: 10.18586/msufbd.295598 %U 10.18586/msufbd.295598
ISNAD Çeker, Selçuk , Orhan, Furkan , Güllüce, Medine , Ağar, Güleray . "Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri". Muş Alparslan Üniversitesi Fen Bilimleri Dergisi 5 / 1 (June 2017): 413-418. https://doi.org/10.18586/msufbd.295598