Association of nesfatin-1 levels with fasting and postload glucose levels in patients with hypothyroidism

Abstract

Nesfatin-1, which is known as an anorexigenic peptide, has a potential role in the control of glucose/insulin regulation. We aimed to investigate serum nesfatin-1 levels in patients with untreated hypothyroidism due to Hashimoto’s thyroiditis and correlate with fasting plasma glucose (FPG) and postload glucose levels. This study included 40 patients with hypothyroidism (mean age; 32.3±12.6 years, body mass index (BMI); 27.8±7.9 kg/m2) and 54 age and BMI matched healthy control group (mean age; 29.3±8.5 years BMI; 29.7±7kg/m2). All subjects underwent a 75 gr oral glucose tolerance test. Serum nesfatin 1 levels were similar among the hypothyroid subjects and control group (14.1±13.4 vs 16.7±15.4 ng/ml, respectively) (p=0.152). FPG (95±8 vs 96.6±7.9 mg/dl) and 2 h postload glucose (113.6±26.7 vs 113.1±27.5 mg/dL) levels did not differ between the two groups (p=0.339, p=0.976 (respectively)). There was no significant correlation between nesfatin-1 and free T3, free T4, TSH, anti-thyroglobulin autoantibody (TGAb) and antithyroid peroxidase autoantibody (TPOAb) (p>0.05). While nesfatin 1 levels did not correlate with FPG, 2 h postload glucose, The Homeostasis Model Assessment (HOMAIR), total-cholesterol, HDL-cholesterol and LDL-cholesterol levels, it showed a negative correlation with triglyceride levels (p=0.008). Nesfatin-1 levels were not associated with FPG and postload glucose levels in patients with hypothyroidism.

Keywords

• Glucose
• Homeostasis model assessment insulin
• resistance index
• Hypothyroidism
• Nesfatin-1
• Triglyceride

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