Year 2019, Volume 12, Issue 2, Pages 269 - 279 2019-05-28

Which one is the predictor of carotid intima media thickness in patients with aglomerulonephritis; neutrophil-to-lymphocyte ratio or proteinuria?
Glomerülonefritli hastalarda karotis intima media kalınlığının prediktörü hangisidir; nötrofil-lenfosit oranı mı proteinüri mi?

Aysun Toraman [1] , Berna Eren [2] , Fatih Duzgun [3] , Fatma Taneli [4] , Seyhun Kursat [5]

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Purpose:Glomerulonephritis is inflammation of the glomeruli and proteinuria itself is a reflection of the glomerular inflammation. In this study we aimed to investigate the relationship between carotid intima media thickness (CIMT) one of the earliest findings of atherosclerosis and markers of glomerular inflammation.

Materials and methods:40 patients with biopsy proven glomerulonephritis and 46 healthy controls were enrolled in the study.Human Growth arrest spesific protein 6 (Gas6) levels in serum samples were studied by ELISA.CIMT measurement was performed by the same radiologist.

Results: The mean age was 42,88±15,41in patient group and 38,26±9,04 in controls. The mean duration of illness was 29.07±52.90 mounts, proteinuria  was4027.05±4030.22 mg/day, MDRD-GFR  was 53.80±48.32 mL/min/1.73m2. CIMT was 0.62±0.17 mm in patient group,0.46±0.10 mm in  controls.Neutrophil-to-Lymphocyte Ratio (NLR) was 3.69±4.46 in patient group and significantly higher than control group (1.74±0.63). Gas6 levels were statistically higher in control group. CIMT was positively correlated with age, fibrinogen, ferritin, proteinuria and NLR and negatively correlated with HDL cholesterol and Gas6  in glomerulonephritis group.  Age  was the predictor  for CIMT in the logistic regression model. In all group CIMT was positively correlated with age, creatinine, uric acid, fibrinogen, ferritin, CaxP product, proteinuria and NLR and negatively correlated with hemoglobin level, Gas6. In lineer logistic regression analysis carotid IMT was significantly associated with age and ferritin and proteinuria.

Conclusion: We have shown that proteinuria is one of the main determinants of increased CIMT independent from the GFR levels in glomerulonephritis with relatively preserved renal function. 

Amaç:Glomerülonefrit glomerüllerin inflamasyondur ve proteinüri kendisi glomerüler inflamasyonun klinik bir yansımasıdır. Bu çalışmada, aterosklerozun en erken bulgularından biri olan karotis intima media kalınlığı (KIMK) ile glomerüler inflamasyon belirteçleri arasındaki ilişkiyi araştırmayı amaçladık.

Gereç ve yöntem: Biyopsi ile kanıtlanmış 40 glomerülonefrit hastası ve 46 sağlıklı kontrol çalışmaya dahil edildi. Serum örneklerinde Growth arrest spesific protein 6 (Gas6) düzeyleri ELISA ile çalışıldı. KIMK ölçümü aynı radyolog tarafından yapıldı. Nötrofil-lenfosit oranı (NLO) tam kan test sonucundan elde edilen nötrofil sayısının lenfosit sayısına bölünmesiyle hesaplandı.

Bulgular: Hasta grubunda ortalama yaş 42,88±15,41, kontrol grubunda 38,26±9,04 idi. Ortalama hastalık süresi 29.07±52.90 ay, proteinüri 4027.05±4030.22 mg/gün, MDRD-GFR 53.80±48.32 mL/dk/1.73m2 idi. KIMK hasta grubunda 0.62±0.17 mm, kontrol grubunda 0.46±0.10 mm idi. NLO hasta grubunda 3.69±4.46, kontrol grubundan anlamlı derecede yüksekti (1.74±0.63). Kontrol grubunda Gas6 düzeyleri istatistiksel olarak daha yüksekti. KIMK yaş, fibrinojen, ferritin, proteinüri ve NLO ile pozitif korelasyon gösterdi ve glomerülonefrit grubunda HDL kolesterol ve Gas6 ile negatif korelasyon gösterdi. Lojistik regresyon modelinde yaş KIMK için belirleyiciydi. Tüm grupta KIMK yaş, kreatinin, ürik asit, fibrinojen, ferritin, CaxP çarpımı, proteinüri ve NLO ile pozitif ve hemoglobin düzeyi, Gas6 ile negatif korelasyon gösterdi. Lineer lojistik regresyon analizinde karotis IMK, yaş ve ferritin ve proteinüri ile anlamlı şekilde ilişkiliydi.

Sonuç: Çalışmamızda proteinürinin böbrek fonksiyonu göreceli olarak korunmuş glomerülonefritte GFR düzeylerinden bağımsız olarak artmış KIMK'nın temel belirleyicilerinden biri olduğunu gösterdik.

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Primary Language en
Subjects Medicine
Published Date Mayıs 2019
Journal Section Research Article
Authors

Orcid: 0000-0003-2290-3342
Author: Aysun Toraman (Primary Author)
Institution: Celal Bayar University, Department of Internal Medicine, Division of Nephrology
Country: Turkey


Orcid: 0000-0003-1459-3663
Author: Berna Eren
Institution: Celal Bayar University, Department of Internal Medicine, Division of Nephrology
Country: Turkey


Orcid: 0000-0003-2199-0640
Author: Fatih Duzgun
Institution: Celal Bayar University, Department of Radiology
Country: Turkey


Orcid: 0000-0002-5194-0460
Author: Fatma Taneli
Institution: Celal Bayar University, Department of Biochemistry
Country: Turkey


Orcid: 0000-0001-9437-8474
Author: Seyhun Kursat
Institution: Celal Bayar University, Department of Internal Medicine, Division of Nephrology
Country: Turkey


Bibtex @research article { patd500277, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale University}, year = {2019}, volume = {12}, pages = {269 - 279}, doi = {10.31362/patd.500277}, title = {Which one is the predictor of carotid intima media thickness in patients with aglomerulonephritis; neutrophil-to-lymphocyte ratio or proteinuria?}, key = {cite}, author = {Toraman, Aysun and Eren, Berna and Duzgun, Fatih and Taneli, Fatma and Kursat, Seyhun} }
APA Toraman, A , Eren, B , Duzgun, F , Taneli, F , Kursat, S . (2019). Which one is the predictor of carotid intima media thickness in patients with aglomerulonephritis; neutrophil-to-lymphocyte ratio or proteinuria?. Pamukkale Tıp Dergisi, 12 (2), 269-279. DOI: 10.31362/patd.500277
MLA Toraman, A , Eren, B , Duzgun, F , Taneli, F , Kursat, S . "Which one is the predictor of carotid intima media thickness in patients with aglomerulonephritis; neutrophil-to-lymphocyte ratio or proteinuria?". Pamukkale Tıp Dergisi 12 (2019): 269-279 <http://dergipark.org.tr/patd/issue/45448/500277>
Chicago Toraman, A , Eren, B , Duzgun, F , Taneli, F , Kursat, S . "Which one is the predictor of carotid intima media thickness in patients with aglomerulonephritis; neutrophil-to-lymphocyte ratio or proteinuria?". Pamukkale Tıp Dergisi 12 (2019): 269-279
RIS TY - JOUR T1 - Which one is the predictor of carotid intima media thickness in patients with aglomerulonephritis; neutrophil-to-lymphocyte ratio or proteinuria? AU - Aysun Toraman , Berna Eren , Fatih Duzgun , Fatma Taneli , Seyhun Kursat Y1 - 2019 PY - 2019 N1 - doi: 10.31362/patd.500277 DO - 10.31362/patd.500277 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 269 EP - 279 VL - 12 IS - 2 SN - -1308-0865 M3 - doi: 10.31362/patd.500277 UR - https://doi.org/10.31362/patd.500277 Y2 - 2019 ER -
EndNote %0 Pamukkale Tıp Dergisi Which one is the predictor of carotid intima media thickness in patients with aglomerulonephritis; neutrophil-to-lymphocyte ratio or proteinuria? %A Aysun Toraman , Berna Eren , Fatih Duzgun , Fatma Taneli , Seyhun Kursat %T Which one is the predictor of carotid intima media thickness in patients with aglomerulonephritis; neutrophil-to-lymphocyte ratio or proteinuria? %D 2019 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 12 %N 2 %R doi: 10.31362/patd.500277 %U 10.31362/patd.500277
ISNAD Toraman, Aysun , Eren, Berna , Duzgun, Fatih , Taneli, Fatma , Kursat, Seyhun . "Which one is the predictor of carotid intima media thickness in patients with aglomerulonephritis; neutrophil-to-lymphocyte ratio or proteinuria?". Pamukkale Tıp Dergisi 12 / 2 (May 2019): 269-279. https://doi.org/10.31362/patd.500277