Design and Construction of a Novel Micro-Extrusion System for Bio-printing Applications

Yıl 2016, Special Issue (2016), 52 - 56, 01.12.2016

Levent Aydın Assoc. Prof. Serdar Küçük Assoc. Prof. Halime Kenar

https://doi.org/10.18100/ijamec.264681

Cited By: 4

Öz

Three-dimensional (3d) bio-printing is one of
the major research fields of future, as yet at the beginning stage but
producing promising solutions in medicine. As technology evolves, novel systems
emerge for positioning even a single cell to the desired place to create
functional tissues. The precision of these systems determine the functionality
of outputs. In general, bio-printers use Ink-jet, Micro-extrusion and Laser
Assisted printing methods to construct a solid tissue or a part of an organ.
Ink-jet method, also known as drop-on-demand bio-printing approach, is based on
spraying cells by means of thermal or piezo electric pulses from numerous
nozzles and is commonly used when forming tissues like skin and cartilage.
Micro-extrusion method is used when complex biological structures like blood
vessels or solid organs are bio-printed. Laser Assisted method is more
preferred for biomaterial or implant production. Components of these systems
have direct effects on the output since they determine where and how much
biological material will be deposited in every layer. The aim of this study is
to design and construct a novel micro-extrusion module for bio-printing
applications. The designed module consists of three-dimensional (3d) printed
body parts from Polylactic acid (PLA), Nema type stepper motors, ball screws
(SFU1204), ball screw nuts (M12), flexible couplings (5 x 8 x 25 mm), steel
rods (M8), SCE UU series bearings (SCE 8 UU), UFL series bearings (UFL 08), LMEF
series bearings (LMEF 8 UU), SK series rod holders (SK 08) and has an ability
to control three commercially available syringes with blunt ended needles. For
precise micro-extrusion, galvanized steel rods support ball screw driven linear
motions. Ergonomically, syringes can be easily mount and locked and this system
also has laser holders that can be used for targeted photo polymerization.

Anahtar Kelimeler

Bio-printing, Micro-extrusion module, Three syringes, Photo polymerization

Kaynakça

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