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Oxidative stress and vascular function

Yıl 2013, Cilt: 5 Sayı: 1, 221 - 231, 11.11.2013

Öz

Many drug-induced complications and diseases are known to be associated with or even based on a dysequilibrium between the formation of reactive oxygen or nitrogen species (RONS) and the expression/activity of antioxidant enzymes that catalyze the breakdown of these harmful reactive species. The “kindling radical” concept is based on the initial formation of RONS that in turn activate additional sources of RONS in certain pathological conditions. Recently, we and others have demonstrated such “cross-talk” between NADPH oxidases and mitochondria in the setting of nitroglycerin-induced nitrate tolerance, the aging process and angiotensin-II triggered arterial hypertension via redox pathways compromising the mitochondrial, ATP-sensitive potassium channel (mKATP), the mitochondrial permeability transition pore (mPTP), cSrc and protein kinases and the NADPH oxidase isoform Nox2 (and eventually Nox1). This review will focus on the uncoupling of endothelial nitric oxide synthase (eNOS) by initially formed “kindling radicals” (RONS) and on the different “redox switches” that are involved in the uncoupling process of eNOS. S-glutathionylation of the eNOS reductase domain, adverse phosphorylation of eNOS, and of course the oxidative depletion of tetrahydrobiopterin (BH4) will be highlighted as potential “redox switches” in eNOS. In addition, RONS-triggered increases in levels of asymmetric dimethylarginine (ADMA) and L-arginine depletion will be discussed as alternative reasons for dysfunctional eNOS. Finally, we present the clinical perspectives of eNOS uncoupling (and dysfunction) for the development and progression of cardiovascular disease and discuss the important prognostic value of the measurement of endothelial function (e.g. by flow-mediated dilation or forearm plethysmography) for patients with cardiovascular disease.

Kaynakça

  • Alp NJ, Mussa S, Khoo J, Cai S, Guzik T, Jefferson A, Goh N, Rockett KA and Channon KM. 2003. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J Clin Invest 112: 725-735.
  • Antoniades C, Shirodaria C, Warrick N, Cai S, de Bono J, Lee J, Leeson P, Neubauer S, Ratnatunga C, Pillai R, Refsum H and Channon KM. 2006. 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation 114: 1193-1201.
  • Berkenboom G, Fontaine D, Unger P, Baldassarre S, Preumont N and Fontaine J. 1999. Absence of nitrate tolerance after long-term treatment with ramipril: an endothelium- dependent mechanism. J Cardiovasc Pharmacol 34: 547- 553.
  • Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann L, Lewis W, Harrison DG and Dikalov SI. 2010. Therapeutic targeting of mitochondrial superoxide in hypertension. Circ Res 107: 106-116.
  • Dikalova AE, Gongora MC, Harrison DG, Lambeth JD, Dikalov S and Griendling KK. 2010. Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. Am J Physiol Heart Circ Physiol 299: H673-679.
  • Doughan AK, Harrison DG and Dikalov SI. 2008. Molecular mechanisms of angiotensin II- mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circ Res 102: 488- 496.
  • Drexler H and Zeiher AM. 1991. Endothelial function in human coronary arteries in vivo. Focus on hypercholesterolemia. Hypertension 18: II90-99.
  • Duffy SJ, Gokce N, Holbrook M, Hunter LM, Biegelsen ES, Huang A, Keaney JF, Jr. and Vita JA. 2001. Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension. Am J Physiol Heart Circ Physiol 280: H528-534.
  • Forstermann U and Munzel T. 2006. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113: 1708-1714.
  • Furchgott RF and Zawadzki JV. 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376.
  • Gokce N, Keaney JF, Jr., Hunter LM, Watkins MT, Menzoian JO and Vita JA. 2002. Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study. Circulation 105: 1567-1572.
  • Gori T, Burstein JM, Ahmed S, Miner SE, Al-Hesayen A, Kelly S and Parker JD. 2001. Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo study. Circulation 104: 1119-1123.
  • Heitzer T, Brockhoff C, Mayer B, Warnholtz A, Mollnau H, Henne S, Meinertz T and Munzel T. 2000. Tetrahydrobiopterin improves endothelium- dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase. Circ Res 86: E36-41.
  • Heitzer T, Finckh B, Albers S, Krohn K, Kohlschutter A and Meinertz T. 2001. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium- dependent, nitric oxide mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Free Radic Biol Med 31: 53-61.
  • Heitzer T, Just H, Brockhoff C, Meinertz T, Olschewski M and Munzel T. 1998. Long-term nitroglycerin treatment is associated with supersensitivity to vasoconstrictors in men with stable coronary artery disease: prevention by concomitant treatment with captopril. J Am Coll Cardiol 31: 83-88.
  • Heitzer T, Just H and Munzel T. 1996. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation 94: 6-9.
  • Heitzer T, Krohn K, Albers S and Meinertz T. 2000. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia 43: 1435-1438.
  • Heitzer T, Schlinzig T, Krohn K, Meinertz T and Munzel T. 2001. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104: 2673-2678.
  • Heitzer T, Yla-Herttuala S, Luoma J, Kurz S, Munzel T, Just H, Olschewski M and Drexler H. 1996. Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia. Role of oxidized LDL. Circulation 93: 1346-1353.
  • Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling K, Harrison DG, Forstermann U and Munzel T. 2001. Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus. Circ Res 88: E14-E22.
  • Oelze M, Daiber A, Brandes RP, Hortmann M, Wenzel P, Hink U, Schulz E, Mollnau H, von Sandersleben A, Kleschyov AL, Mulsch A, Li H, Forstermann U and Munzel T. 2006. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension 48: 677-684.
  • Oelze M, Schuhmacher S and Daiber A. 2010. Organic nitrates and nitrate resistance in diabetes: the role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate. Exp Diabetes Res 2010: 213176.
  • Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, Chaturvedi N, Ghadanfar M, Weissbach N, Xiang Z, Armbrecht J and Pfeffer MA. 2009. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrol Dial Transplant 24: 1663- 1671.
  • Perticone F, Ceravolo R, Pujia A, Ventura G, Iacopino S, Scozzafava A, Ferraro A, Chello M, Mastroroberto P, Verdecchia P and Schillaci G. 2001. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 104: 191-196.
  • Pitt B, Stier CT, Jr. and Rajagopalan S. 2003. Mineralocorticoid receptor blockade: new insights into the mechanism of action in patients with cardiovascular disease. J Renin Angiotensin Aldosterone Syst 4: 164-168.
  • Schuhmacher S, Wenzel P, Schulz E, Oelze M, Mang C, Kamuf J, Gori T, Jansen T, Knorr M, Karbach S, Hortmann M, Mathner F, Bhatnagar A, Forstermann U, Li H, Munzel T and Daiber A. 2010. Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1. Hypertension 55: 897-904.
  • Schulz E, Jansen T, Wenzel P, Daiber A and Munzel T. 2008. Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. Antioxid Redox Signal 10: 1115-1126.
  • Schulz E, Wenzel P, Munzel T and Daiber A. 2012. Mitochondrial redox signaling: interaction of mitochondrial reactive oxygen species with other sources of oxidative stress. Antioxid Redox Signal Epub ahead of print: doi:10.1089/ ars.2012.4609.
  • Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P and Creager MA. 1996. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 97: 22-28.
  • Tzemos N, Lim PO and MacDonald TM. 2001. Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover study. Circulation 104: 511- 514.
  • Wang S, Xu J, Song P, Wu Y, Zhang J, Chul Choi H and Zou MH. 2008. Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure. Hypertension 52: 484-490.
  • Warnholtz A, Ostad MA, Heitzer T, Thuneke F, Frohlich M, Tschentscher P, Schwedhelm E, Boger R, Meinertz T and Munzel T. 2007. AT1-receptor blockade with irbesartan improves peripheral but not coronary endothelial dysfunction in patients with stable coronary artery disease. Atherosclerosis 194: 439-445.
  • Wenzel P, Schulz E, Oelze M, Muller J, Schuhmacher S, Alhamdani MS, Debrezion J, Hortmann M, Reifenberg K, Fleming I, Munzel T and Daiber A. 2008. AT1- receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats. Free Radic Biol Med 45: 619-626.
  • Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy MA, Simonson DC and Creager MA. 1998. Acute hyperglycemia attenuates endothelium- dependent vasodilation in humans in vivo. Circulation 97: 1695-1701.
  • Xia N, Daiber A, Habermeier A, Closs EI, Thum T, Spanier G, Lu Q, Oelze M, Torzewski M, Lackner KJ, Munzel T, Forstermann U and Li H. 2010. Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther 335: 149-154.
Yıl 2013, Cilt: 5 Sayı: 1, 221 - 231, 11.11.2013

Öz

Kaynakça

  • Alp NJ, Mussa S, Khoo J, Cai S, Guzik T, Jefferson A, Goh N, Rockett KA and Channon KM. 2003. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J Clin Invest 112: 725-735.
  • Antoniades C, Shirodaria C, Warrick N, Cai S, de Bono J, Lee J, Leeson P, Neubauer S, Ratnatunga C, Pillai R, Refsum H and Channon KM. 2006. 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation 114: 1193-1201.
  • Berkenboom G, Fontaine D, Unger P, Baldassarre S, Preumont N and Fontaine J. 1999. Absence of nitrate tolerance after long-term treatment with ramipril: an endothelium- dependent mechanism. J Cardiovasc Pharmacol 34: 547- 553.
  • Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann L, Lewis W, Harrison DG and Dikalov SI. 2010. Therapeutic targeting of mitochondrial superoxide in hypertension. Circ Res 107: 106-116.
  • Dikalova AE, Gongora MC, Harrison DG, Lambeth JD, Dikalov S and Griendling KK. 2010. Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. Am J Physiol Heart Circ Physiol 299: H673-679.
  • Doughan AK, Harrison DG and Dikalov SI. 2008. Molecular mechanisms of angiotensin II- mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circ Res 102: 488- 496.
  • Drexler H and Zeiher AM. 1991. Endothelial function in human coronary arteries in vivo. Focus on hypercholesterolemia. Hypertension 18: II90-99.
  • Duffy SJ, Gokce N, Holbrook M, Hunter LM, Biegelsen ES, Huang A, Keaney JF, Jr. and Vita JA. 2001. Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension. Am J Physiol Heart Circ Physiol 280: H528-534.
  • Forstermann U and Munzel T. 2006. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113: 1708-1714.
  • Furchgott RF and Zawadzki JV. 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376.
  • Gokce N, Keaney JF, Jr., Hunter LM, Watkins MT, Menzoian JO and Vita JA. 2002. Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study. Circulation 105: 1567-1572.
  • Gori T, Burstein JM, Ahmed S, Miner SE, Al-Hesayen A, Kelly S and Parker JD. 2001. Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo study. Circulation 104: 1119-1123.
  • Heitzer T, Brockhoff C, Mayer B, Warnholtz A, Mollnau H, Henne S, Meinertz T and Munzel T. 2000. Tetrahydrobiopterin improves endothelium- dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase. Circ Res 86: E36-41.
  • Heitzer T, Finckh B, Albers S, Krohn K, Kohlschutter A and Meinertz T. 2001. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium- dependent, nitric oxide mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Free Radic Biol Med 31: 53-61.
  • Heitzer T, Just H, Brockhoff C, Meinertz T, Olschewski M and Munzel T. 1998. Long-term nitroglycerin treatment is associated with supersensitivity to vasoconstrictors in men with stable coronary artery disease: prevention by concomitant treatment with captopril. J Am Coll Cardiol 31: 83-88.
  • Heitzer T, Just H and Munzel T. 1996. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation 94: 6-9.
  • Heitzer T, Krohn K, Albers S and Meinertz T. 2000. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia 43: 1435-1438.
  • Heitzer T, Schlinzig T, Krohn K, Meinertz T and Munzel T. 2001. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104: 2673-2678.
  • Heitzer T, Yla-Herttuala S, Luoma J, Kurz S, Munzel T, Just H, Olschewski M and Drexler H. 1996. Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia. Role of oxidized LDL. Circulation 93: 1346-1353.
  • Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling K, Harrison DG, Forstermann U and Munzel T. 2001. Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus. Circ Res 88: E14-E22.
  • Oelze M, Daiber A, Brandes RP, Hortmann M, Wenzel P, Hink U, Schulz E, Mollnau H, von Sandersleben A, Kleschyov AL, Mulsch A, Li H, Forstermann U and Munzel T. 2006. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension 48: 677-684.
  • Oelze M, Schuhmacher S and Daiber A. 2010. Organic nitrates and nitrate resistance in diabetes: the role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate. Exp Diabetes Res 2010: 213176.
  • Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, Chaturvedi N, Ghadanfar M, Weissbach N, Xiang Z, Armbrecht J and Pfeffer MA. 2009. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrol Dial Transplant 24: 1663- 1671.
  • Perticone F, Ceravolo R, Pujia A, Ventura G, Iacopino S, Scozzafava A, Ferraro A, Chello M, Mastroroberto P, Verdecchia P and Schillaci G. 2001. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 104: 191-196.
  • Pitt B, Stier CT, Jr. and Rajagopalan S. 2003. Mineralocorticoid receptor blockade: new insights into the mechanism of action in patients with cardiovascular disease. J Renin Angiotensin Aldosterone Syst 4: 164-168.
  • Schuhmacher S, Wenzel P, Schulz E, Oelze M, Mang C, Kamuf J, Gori T, Jansen T, Knorr M, Karbach S, Hortmann M, Mathner F, Bhatnagar A, Forstermann U, Li H, Munzel T and Daiber A. 2010. Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1. Hypertension 55: 897-904.
  • Schulz E, Jansen T, Wenzel P, Daiber A and Munzel T. 2008. Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. Antioxid Redox Signal 10: 1115-1126.
  • Schulz E, Wenzel P, Munzel T and Daiber A. 2012. Mitochondrial redox signaling: interaction of mitochondrial reactive oxygen species with other sources of oxidative stress. Antioxid Redox Signal Epub ahead of print: doi:10.1089/ ars.2012.4609.
  • Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P and Creager MA. 1996. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 97: 22-28.
  • Tzemos N, Lim PO and MacDonald TM. 2001. Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover study. Circulation 104: 511- 514.
  • Wang S, Xu J, Song P, Wu Y, Zhang J, Chul Choi H and Zou MH. 2008. Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure. Hypertension 52: 484-490.
  • Warnholtz A, Ostad MA, Heitzer T, Thuneke F, Frohlich M, Tschentscher P, Schwedhelm E, Boger R, Meinertz T and Munzel T. 2007. AT1-receptor blockade with irbesartan improves peripheral but not coronary endothelial dysfunction in patients with stable coronary artery disease. Atherosclerosis 194: 439-445.
  • Wenzel P, Schulz E, Oelze M, Muller J, Schuhmacher S, Alhamdani MS, Debrezion J, Hortmann M, Reifenberg K, Fleming I, Munzel T and Daiber A. 2008. AT1- receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats. Free Radic Biol Med 45: 619-626.
  • Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy MA, Simonson DC and Creager MA. 1998. Acute hyperglycemia attenuates endothelium- dependent vasodilation in humans in vivo. Circulation 97: 1695-1701.
  • Xia N, Daiber A, Habermeier A, Closs EI, Thum T, Spanier G, Lu Q, Oelze M, Torzewski M, Lackner KJ, Munzel T, Forstermann U and Li H. 2010. Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther 335: 149-154.
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Derleme
Yazarlar

Andreas Daiber

Michael Mader Bu kişi benim

Paul Stamm Bu kişi benim

Elena Zinãÿius Bu kişi benim

Swenja Kröller-schön Bu kişi benim

Matthias Oelze Bu kişi benim

Thomas Münzel Bu kişi benim

Yayımlanma Tarihi 11 Kasım 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 5 Sayı: 1

Kaynak Göster

APA Daiber, A., Mader, M., Stamm, P., Zinãÿius, E., vd. (2013). Oxidative stress and vascular function. Cell Membranes and Free Radical Research, 5(1), 221-231.
AMA Daiber A, Mader M, Stamm P, Zinãÿius E, Kröller-schön S, Oelze M, Münzel T. Oxidative stress and vascular function. Cell Membranes and Free Radical Research. Kasım 2013;5(1):221-231.
Chicago Daiber, Andreas, Michael Mader, Paul Stamm, Elena Zinãÿius, Swenja Kröller-schön, Matthias Oelze, ve Thomas Münzel. “Oxidative Stress and Vascular Function”. Cell Membranes and Free Radical Research 5, sy. 1 (Kasım 2013): 221-31.
EndNote Daiber A, Mader M, Stamm P, Zinãÿius E, Kröller-schön S, Oelze M, Münzel T (01 Kasım 2013) Oxidative stress and vascular function. Cell Membranes and Free Radical Research 5 1 221–231.
IEEE A. Daiber, “Oxidative stress and vascular function”, Cell Membranes and Free Radical Research, c. 5, sy. 1, ss. 221–231, 2013.
ISNAD Daiber, Andreas vd. “Oxidative Stress and Vascular Function”. Cell Membranes and Free Radical Research 5/1 (Kasım 2013), 221-231.
JAMA Daiber A, Mader M, Stamm P, Zinãÿius E, Kröller-schön S, Oelze M, Münzel T. Oxidative stress and vascular function. Cell Membranes and Free Radical Research. 2013;5:221–231.
MLA Daiber, Andreas vd. “Oxidative Stress and Vascular Function”. Cell Membranes and Free Radical Research, c. 5, sy. 1, 2013, ss. 221-3.
Vancouver Daiber A, Mader M, Stamm P, Zinãÿius E, Kröller-schön S, Oelze M, Münzel T. Oxidative stress and vascular function. Cell Membranes and Free Radical Research. 2013;5(1):221-3.