Year 2012, Volume 42, Issue 3, Pages 425 - 431 2012-03-01

Increased nitrite levels in exhaled breath condensate in asthma-like syndrome induced by occupational sulfur dioxide exposure*
Increased nitrite levels in exhaled breath condensate in asthma-like syndrome induced by occupational sulfur dioxide exposure*

Zeki YILDIRIM [1] , Sadık SÖĞÜT [2] , Nurhan KÖKSAL [3] , Talat KILIÇ [4]

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To investigate whether nitrite levels were abnormally high in expired breath condensate (EBC) from workers with asthma-like syndrome. Materials and methods: We measured the nitrite levels in EBC from 48 volunteer workers, including 25 smokers, with asthma-like syndrome before and after SO2 exposure and compared these levels with those from 44 nonexposed control subjects, including 23 smokers. Results: Baseline concentrations of nitrite in the workers before SO2 exposure were higher (19.31 ± 1.06 nmol/mL) than in the controls (13.08 ± 1.36 nmol/mL; P < 0.001). Acute SO2 exposure produced a significant increase in concentrations of nitrite (23.62 ± 1.36) compared to the baseline value (P < 0.05). Preexposure nitrite concentrations were similar in smoking and nonsmoking workers (17.85 ± 1.72 and 20.20 ± 1.59; P > 0.05). Conclusion: We concluded that nitrite levels in EBC are increased in the asthma-like syndrome induced by occupational SO2 exposure in an agricultural environment, suggesting the role of inflammation in the syndrome; this first application of the EBC method may be suitable in other field studies in occupational medicine.
To investigate whether nitrite levels were abnormally high in expired breath condensate (EBC) from workers with asthma-like syndrome. Materials and methods: We measured the nitrite levels in EBC from 48 volunteer workers, including 25 smokers, with asthma-like syndrome before and after SO2 exposure and compared these levels with those from 44 nonexposed control subjects, including 23 smokers. Results: Baseline concentrations of nitrite in the workers before SO2 exposure were higher (19.31 ± 1.06 nmol/mL) than in the controls (13.08 ± 1.36 nmol/mL; P < 0.001). Acute SO2 exposure produced a significant increase in concentrations of nitrite (23.62 ± 1.36) compared to the baseline value (P < 0.05). Preexposure nitrite concentrations were similar in smoking and nonsmoking workers (17.85 ± 1.72 and 20.20 ± 1.59; P > 0.05). Conclusion: We concluded that nitrite levels in EBC are increased in the asthma-like syndrome induced by occupational SO2 exposure in an agricultural environment, suggesting the role of inflammation in the syndrome; this first application of the EBC method may be suitable in other field studies in occupational medicine.
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Subjects
Journal Section Articles
Authors

Author: Zeki YILDIRIM

Author: Sadık SÖĞÜT

Author: Nurhan KÖKSAL

Author: Talat KILIÇ

Bibtex @ { tbtkmedical147105, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {TUBITAK}, year = {2012}, volume = {42}, pages = {425 - 431}, doi = {}, title = {Increased nitrite levels in exhaled breath condensate in asthma-like syndrome induced by occupational sulfur dioxide exposure*}, key = {cite}, author = {YILDIRIM, Zeki and SÖĞÜT, Sadık and KÖKSAL, Nurhan and KILIÇ, Talat} }
APA YILDIRIM, Z , SÖĞÜT, S , KÖKSAL, N , KILIÇ, T . (2012). Increased nitrite levels in exhaled breath condensate in asthma-like syndrome induced by occupational sulfur dioxide exposure*. Turkish Journal of Medical Sciences, 42 (3), 425-431. Retrieved from http://dergipark.org.tr/tbtkmedical/issue/12298/147105
MLA YILDIRIM, Z , SÖĞÜT, S , KÖKSAL, N , KILIÇ, T . "Increased nitrite levels in exhaled breath condensate in asthma-like syndrome induced by occupational sulfur dioxide exposure*". Turkish Journal of Medical Sciences 42 (2012): 425-431 <http://dergipark.org.tr/tbtkmedical/issue/12298/147105>
Chicago YILDIRIM, Z , SÖĞÜT, S , KÖKSAL, N , KILIÇ, T . "Increased nitrite levels in exhaled breath condensate in asthma-like syndrome induced by occupational sulfur dioxide exposure*". Turkish Journal of Medical Sciences 42 (2012): 425-431
RIS TY - JOUR T1 - Increased nitrite levels in exhaled breath condensate in asthma-like syndrome induced by occupational sulfur dioxide exposure* AU - Zeki YILDIRIM , Sadık SÖĞÜT , Nurhan KÖKSAL , Talat KILIÇ Y1 - 2012 PY - 2012 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 425 EP - 431 VL - 42 IS - 3 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Medical Sciences Increased nitrite levels in exhaled breath condensate in asthma-like syndrome induced by occupational sulfur dioxide exposure* %A Zeki YILDIRIM , Sadık SÖĞÜT , Nurhan KÖKSAL , Talat KILIÇ %T Increased nitrite levels in exhaled breath condensate in asthma-like syndrome induced by occupational sulfur dioxide exposure* %D 2012 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 42 %N 3 %R %U
ISNAD YILDIRIM, Zeki , SÖĞÜT, Sadık , KÖKSAL, Nurhan , KILIÇ, Talat . "Increased nitrite levels in exhaled breath condensate in asthma-like syndrome induced by occupational sulfur dioxide exposure*". Turkish Journal of Medical Sciences 42 / 3 (March 2012): 425-431.