Year 2015, Volume 45, Issue 6, Pages 1207 - 1213 2015-12-04

The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis
The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis

AYŞEGÜL AKAN [1] , MÜGE TOYRAN [2] , EMİNE VEZİR [3] , DİLEK AZKUR [4] , AYŞENUR KAYA [5] , MUSTAFA ERKOÇOĞLU [6] , ERSOY CİVELEK [7] , EMİNE DİBEK MISIRLIOĞLU [8] , CAN NACİ KOCABAŞ [9]

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Background/aim: Data about contact allergen sensitization (CAS) in children with atopic dermatitis (AD) are limited. The purpose of this study was to identify the frequency and patterns of CAS in children with AD by using a ready-to-use patch test system. Materials and methods: After receiving the history of CAS in the patients, the severity of AD and IgE-mediated allergen sensitization were determined. Results: Of 134 children with AD, 33.8% (n = 45) had at least 1 positive reaction. The most frequent positive reaction was to nickel sulfate (NS) (37.8%, 17/45), followed by methylchloroisothiazolinone (20.0%, 9/45) and thimerosal (15.6%, 7/45). The total Scoring Atopic Dermatitis (SCORAD) score was significantly higher in the NS-sensitized group (P = 0.036). The patients with NS sensitization had moderate-severe AD more frequently than those without any reaction (P = 0.020). When the SCORAD score was evaluated in detail, extent of eczema, score of sleep loss, and pruritus were significantly higher in the patients with NS sensitization than those without any reaction (P = 0.002, P = 0.001, and P = 0.002, respectively). Conclusion: Our study confirms the necessity of CAS in the management of AD. In particular, NS sensitization should be considered for children with severe AD or larger extent of eczema and trunk involvement.
Background/aim: Data about contact allergen sensitization (CAS) in children with atopic dermatitis (AD) are limited. The purpose of this study was to identify the frequency and patterns of CAS in children with AD by using a ready-to-use patch test system. Materials and methods: After receiving the history of CAS in the patients, the severity of AD and IgE-mediated allergen sensitization were determined. Results: Of 134 children with AD, 33.8% (n = 45) had at least 1 positive reaction. The most frequent positive reaction was to nickel sulfate (NS) (37.8%, 17/45), followed by methylchloroisothiazolinone (20.0%, 9/45) and thimerosal (15.6%, 7/45). The total Scoring Atopic Dermatitis (SCORAD) score was significantly higher in the NS-sensitized group (P = 0.036). The patients with NS sensitization had moderate-severe AD more frequently than those without any reaction (P = 0.020). When the SCORAD score was evaluated in detail, extent of eczema, score of sleep loss, and pruritus were significantly higher in the patients with NS sensitization than those without any reaction (P = 0.002, P = 0.001, and P = 0.002, respectively). Conclusion: Our study confirms the necessity of CAS in the management of AD. In particular, NS sensitization should be considered for children with severe AD or larger extent of eczema and trunk involvement.
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Primary Language tr
Journal Section Articles
Authors

Author: AYŞEGÜL AKAN

Author: MÜGE TOYRAN

Author: EMİNE VEZİR

Author: DİLEK AZKUR

Author: AYŞENUR KAYA

Author: MUSTAFA ERKOÇOĞLU

Author: ERSOY CİVELEK

Author: EMİNE DİBEK MISIRLIOĞLU

Author: CAN NACİ KOCABAŞ

Dates

Publication Date: December 4, 2015

Bibtex @ { tbtkmedical149001, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {TUBITAK}, year = {2015}, volume = {45}, pages = {1207 - 1213}, doi = {}, title = {The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis}, key = {cite}, author = {AKAN, AYŞEGÜL and TOYRAN, MÜGE and VEZİR, EMİNE and AZKUR, DİLEK and KAYA, AYŞENUR and ERKOÇOĞLU, MUSTAFA and CİVELEK, ERSOY and MISIRLIOĞLU, EMİNE DİBEK and KOCABAŞ, CAN NACİ} }
APA AKAN, A , TOYRAN, M , VEZİR, E , AZKUR, D , KAYA, A , ERKOÇOĞLU, M , CİVELEK, E , MISIRLIOĞLU, E , KOCABAŞ, C . (2015). The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis. Turkish Journal of Medical Sciences, 45 (6), 1207-1213. Retrieved from http://dergipark.org.tr/tbtkmedical/issue/12391/149001
MLA AKAN, A , TOYRAN, M , VEZİR, E , AZKUR, D , KAYA, A , ERKOÇOĞLU, M , CİVELEK, E , MISIRLIOĞLU, E , KOCABAŞ, C . "The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis". Turkish Journal of Medical Sciences 45 (2015): 1207-1213 <http://dergipark.org.tr/tbtkmedical/issue/12391/149001>
Chicago AKAN, A , TOYRAN, M , VEZİR, E , AZKUR, D , KAYA, A , ERKOÇOĞLU, M , CİVELEK, E , MISIRLIOĞLU, E , KOCABAŞ, C . "The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis". Turkish Journal of Medical Sciences 45 (2015): 1207-1213
RIS TY - JOUR T1 - The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis AU - AYŞEGÜL AKAN , MÜGE TOYRAN , EMİNE VEZİR , DİLEK AZKUR , AYŞENUR KAYA , MUSTAFA ERKOÇOĞLU , ERSOY CİVELEK , EMİNE DİBEK MISIRLIOĞLU , CAN NACİ KOCABAŞ Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1207 EP - 1213 VL - 45 IS - 6 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Medical Sciences The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis %A AYŞEGÜL AKAN , MÜGE TOYRAN , EMİNE VEZİR , DİLEK AZKUR , AYŞENUR KAYA , MUSTAFA ERKOÇOĞLU , ERSOY CİVELEK , EMİNE DİBEK MISIRLIOĞLU , CAN NACİ KOCABAŞ %T The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 6 %R %U
ISNAD AKAN, AYŞEGÜL , TOYRAN, MÜGE , VEZİR, EMİNE , AZKUR, DİLEK , KAYA, AYŞENUR , ERKOÇOĞLU, MUSTAFA , CİVELEK, ERSOY , MISIRLIOĞLU, EMİNE DİBEK , KOCABAŞ, CAN NACİ . "The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis". Turkish Journal of Medical Sciences 45 / 6 (December 2015): 1207-1213.
AMA AKAN A , TOYRAN M , VEZİR E , AZKUR D , KAYA A , ERKOÇOĞLU M , CİVELEK E , MISIRLIOĞLU E , KOCABAŞ C . The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis. Turkish Journal of Medical Sciences. 2015; 45(6): 1207-1213.
Vancouver AKAN A , TOYRAN M , VEZİR E , AZKUR D , KAYA A , ERKOÇOĞLU M , CİVELEK E , MISIRLIOĞLU E , KOCABAŞ C . The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis. Turkish Journal of Medical Sciences. 2015; 45(6): 1213-1207.