Year 2015, Volume 45, Issue 6, Pages 1251 - 1255 2015-12-04

Neopterin, homocysteine, and ADMA levels during and after urticaria attack
Neopterin, homocysteine, and ADMA levels during and after urticaria attack

SALİM KEMAL TUNCER [1] , ÜMİT KALDIRIM [2] , YUSUF EMRAH EYİ [3] , ALİ OSMAN YILDIRIM [4] , ŞAFAK EKİNCİ [5] , KEMAL KARA [6] , MURAT EROĞLU [7] , MUZAFFER ÖZTOSUN [8] , SELAHATTİN ÖZYÜREK [9] , MURAT DURUSU [10] , MUSTAFA GÜLEÇ [11] , TUNCER ÇAYCI [12] , ÖZCAN ALTINEL [13] , HÜSEYİN LEVENT YAMANEL [14]

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Background/aim: Urticaria is a vascular skin reaction characterized with papules and plaques. Neopterin is accepted as an immunologic marker and an indicator of activation of the immune system. Homocysteine and asymmetric dimethylarginine (ADMA) are the markers of increased vascular resistance. Alteration in vascular resistance has a role in the pathogenesis of urticaria. We aimed to investigate whether there is a relationship between urticaria and neopterin, homocysteine, or ADMA. Materials and methods: The study is designed as a prospective descriptive study and patients with a diagnosis of urticaria in the emergency department were included in the study. Demographic data and characteristics of the disease were recorded. Neopterin, homocysteine, and ADMA levels were measured both during and after urticaria attacks. All data were statistically analyzed. Results: The differences between neopterin levels measured during and after urticaria attacks were statistically significant (P < 0.001). The differences between homocysteine and ADMA levels measured during and after urticaria attacks were not statistically significant (P > 0.05). Conclusion: Our results indicate that neopterin levels in patients with urticaria attacks are increased and the level of neopterin is also a useful parameter in acute urticaria. Further studies should clarify whether homocysteine levels contribute to diagnosis of acute urticaria. However, no relation was found between ADMA and urticaria.
Background/aim: Urticaria is a vascular skin reaction characterized with papules and plaques. Neopterin is accepted as an immunologic marker and an indicator of activation of the immune system. Homocysteine and asymmetric dimethylarginine (ADMA) are the markers of increased vascular resistance. Alteration in vascular resistance has a role in the pathogenesis of urticaria. We aimed to investigate whether there is a relationship between urticaria and neopterin, homocysteine, or ADMA. Materials and methods: The study is designed as a prospective descriptive study and patients with a diagnosis of urticaria in the emergency department were included in the study. Demographic data and characteristics of the disease were recorded. Neopterin, homocysteine, and ADMA levels were measured both during and after urticaria attacks. All data were statistically analyzed. Results: The differences between neopterin levels measured during and after urticaria attacks were statistically significant (P < 0.001). The differences between homocysteine and ADMA levels measured during and after urticaria attacks were not statistically significant (P > 0.05). Conclusion: Our results indicate that neopterin levels in patients with urticaria attacks are increased and the level of neopterin is also a useful parameter in acute urticaria. Further studies should clarify whether homocysteine levels contribute to diagnosis of acute urticaria. However, no relation was found between ADMA and urticaria.
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Primary Language tr
Journal Section Articles
Authors

Author: SALİM KEMAL TUNCER

Author: ÜMİT KALDIRIM

Author: YUSUF EMRAH EYİ

Author: ALİ OSMAN YILDIRIM

Author: ŞAFAK EKİNCİ

Author: KEMAL KARA

Author: MURAT EROĞLU

Author: MUZAFFER ÖZTOSUN

Author: SELAHATTİN ÖZYÜREK

Author: MURAT DURUSU

Author: MUSTAFA GÜLEÇ

Author: TUNCER ÇAYCI

Author: ÖZCAN ALTINEL

Author: HÜSEYİN LEVENT YAMANEL

Dates

Publication Date: December 4, 2015

Bibtex @ { tbtkmedical149007, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {TUBITAK}, year = {2015}, volume = {45}, pages = {1251 - 1255}, doi = {}, title = {Neopterin, homocysteine, and ADMA levels during and after urticaria attack}, key = {cite}, author = {TUNCER, SALİM KEMAL and KALDIRIM, ÜMİT and EYİ, YUSUF EMRAH and YILDIRIM, ALİ OSMAN and EKİNCİ, ŞAFAK and KARA, KEMAL and EROĞLU, MURAT and ÖZTOSUN, MUZAFFER and ÖZYÜREK, SELAHATTİN and DURUSU, MURAT and GÜLEÇ, MUSTAFA and ÇAYCI, TUNCER and ALTINEL, ÖZCAN and YAMANEL, HÜSEYİN LEVENT} }
APA TUNCER, S , KALDIRIM, Ü , EYİ, Y , YILDIRIM, A , EKİNCİ, Ş , KARA, K , EROĞLU, M , ÖZTOSUN, M , ÖZYÜREK, S , DURUSU, M , GÜLEÇ, M , ÇAYCI, T , ALTINEL, Ö , YAMANEL, H . (2015). Neopterin, homocysteine, and ADMA levels during and after urticaria attack. Turkish Journal of Medical Sciences, 45 (6), 1251-1255. Retrieved from http://dergipark.org.tr/tbtkmedical/issue/12391/149007
MLA TUNCER, S , KALDIRIM, Ü , EYİ, Y , YILDIRIM, A , EKİNCİ, Ş , KARA, K , EROĞLU, M , ÖZTOSUN, M , ÖZYÜREK, S , DURUSU, M , GÜLEÇ, M , ÇAYCI, T , ALTINEL, Ö , YAMANEL, H . "Neopterin, homocysteine, and ADMA levels during and after urticaria attack". Turkish Journal of Medical Sciences 45 (2015): 1251-1255 <http://dergipark.org.tr/tbtkmedical/issue/12391/149007>
Chicago TUNCER, S , KALDIRIM, Ü , EYİ, Y , YILDIRIM, A , EKİNCİ, Ş , KARA, K , EROĞLU, M , ÖZTOSUN, M , ÖZYÜREK, S , DURUSU, M , GÜLEÇ, M , ÇAYCI, T , ALTINEL, Ö , YAMANEL, H . "Neopterin, homocysteine, and ADMA levels during and after urticaria attack". Turkish Journal of Medical Sciences 45 (2015): 1251-1255
RIS TY - JOUR T1 - Neopterin, homocysteine, and ADMA levels during and after urticaria attack AU - SALİM KEMAL TUNCER , ÜMİT KALDIRIM , YUSUF EMRAH EYİ , ALİ OSMAN YILDIRIM , ŞAFAK EKİNCİ , KEMAL KARA , MURAT EROĞLU , MUZAFFER ÖZTOSUN , SELAHATTİN ÖZYÜREK , MURAT DURUSU , MUSTAFA GÜLEÇ , TUNCER ÇAYCI , ÖZCAN ALTINEL , HÜSEYİN LEVENT YAMANEL Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1251 EP - 1255 VL - 45 IS - 6 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Medical Sciences Neopterin, homocysteine, and ADMA levels during and after urticaria attack %A SALİM KEMAL TUNCER , ÜMİT KALDIRIM , YUSUF EMRAH EYİ , ALİ OSMAN YILDIRIM , ŞAFAK EKİNCİ , KEMAL KARA , MURAT EROĞLU , MUZAFFER ÖZTOSUN , SELAHATTİN ÖZYÜREK , MURAT DURUSU , MUSTAFA GÜLEÇ , TUNCER ÇAYCI , ÖZCAN ALTINEL , HÜSEYİN LEVENT YAMANEL %T Neopterin, homocysteine, and ADMA levels during and after urticaria attack %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 6 %R %U
ISNAD TUNCER, SALİM KEMAL , KALDIRIM, ÜMİT , EYİ, YUSUF EMRAH , YILDIRIM, ALİ OSMAN , EKİNCİ, ŞAFAK , KARA, KEMAL , EROĞLU, MURAT , ÖZTOSUN, MUZAFFER , ÖZYÜREK, SELAHATTİN , DURUSU, MURAT , GÜLEÇ, MUSTAFA , ÇAYCI, TUNCER , ALTINEL, ÖZCAN , YAMANEL, HÜSEYİN LEVENT . "Neopterin, homocysteine, and ADMA levels during and after urticaria attack". Turkish Journal of Medical Sciences 45 / 6 (December 2015): 1251-1255.
AMA TUNCER S , KALDIRIM Ü , EYİ Y , YILDIRIM A , EKİNCİ Ş , KARA K , EROĞLU M , ÖZTOSUN M , ÖZYÜREK S , DURUSU M , GÜLEÇ M , ÇAYCI T , ALTINEL Ö , YAMANEL H . Neopterin, homocysteine, and ADMA levels during and after urticaria attack. Turkish Journal of Medical Sciences. 2015; 45(6): 1251-1255.
Vancouver TUNCER S , KALDIRIM Ü , EYİ Y , YILDIRIM A , EKİNCİ Ş , KARA K , EROĞLU M , ÖZTOSUN M , ÖZYÜREK S , DURUSU M , GÜLEÇ M , ÇAYCI T , ALTINEL Ö , YAMANEL H . Neopterin, homocysteine, and ADMA levels during and after urticaria attack. Turkish Journal of Medical Sciences. 2015; 45(6): 1255-1251.