Year 2015, Volume 45, Issue 6, Pages 1274 - 1279 2015-12-04

Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency
Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency

NİHAT DEMİR [1] , AHMET KOÇ [2] , MAHMUT ABUHANDAN [3] , MUSTAFA ÇALIK [4] , AKIN İŞCAN [5]

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Background/aim: Vitamin B12 plays an important role in the development of mental, motor, cognitive, and social functions via its role in DNA synthesis and nerve myelination. Its deficiency in infants might cause neuromotor retardation as well as megaloblastic anemia. The objective of this study was to investigate the effects of infantile vitamin B12 deficiency on evoked brain potentials and determine whether improvement could be obtained with vitamin B12 replacement at appropriate dosages. Materials and methods: Thirty patients with vitamin B12 deficiency and 30 age-matched healthy controls were included in the study. Hematological parameters, visual evoked potentials, and brainstem auditory evoked potentials tests were performed prior to treatment, 1 week after treatment, and 3 months after treatment. Results: Visual evoked potentials (VEPs) and brainstem auditory evoked potentials (BAEPs) were found to be prolonged in 16 (53.3%) and 15 (50%) patients, respectively. Statistically significant improvements in VEP and BAEP examinations were determined 3 months after treatment. Three months after treatment, VEP and BAEP examinations returned to normal in 81.3% and 53.3% of subjects with prolonged VEPs and BAEPs, respectively. Conclusion: These results demonstrate that vitamin B12 deficiency in infants causes significant impairment in the auditory and visual functioning tests of the brain, such as VEP and BAEP.
Background/aim: Vitamin B12 plays an important role in the development of mental, motor, cognitive, and social functions via its role in DNA synthesis and nerve myelination. Its deficiency in infants might cause neuromotor retardation as well as megaloblastic anemia. The objective of this study was to investigate the effects of infantile vitamin B12 deficiency on evoked brain potentials and determine whether improvement could be obtained with vitamin B12 replacement at appropriate dosages. Materials and methods: Thirty patients with vitamin B12 deficiency and 30 age-matched healthy controls were included in the study. Hematological parameters, visual evoked potentials, and brainstem auditory evoked potentials tests were performed prior to treatment, 1 week after treatment, and 3 months after treatment. Results: Visual evoked potentials (VEPs) and brainstem auditory evoked potentials (BAEPs) were found to be prolonged in 16 (53.3%) and 15 (50%) patients, respectively. Statistically significant improvements in VEP and BAEP examinations were determined 3 months after treatment. Three months after treatment, VEP and BAEP examinations returned to normal in 81.3% and 53.3% of subjects with prolonged VEPs and BAEPs, respectively. Conclusion: These results demonstrate that vitamin B12 deficiency in infants causes significant impairment in the auditory and visual functioning tests of the brain, such as VEP and BAEP.
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Primary Language tr
Journal Section Articles
Authors

Author: NİHAT DEMİR

Author: AHMET KOÇ

Author: MAHMUT ABUHANDAN

Author: MUSTAFA ÇALIK

Author: AKIN İŞCAN

Dates

Publication Date: December 4, 2015

Bibtex @ { tbtkmedical149011, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {TUBITAK}, year = {2015}, volume = {45}, pages = {1274 - 1279}, doi = {}, title = {Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency}, key = {cite}, author = {DEMİR, NİHAT and KOÇ, AHMET and ABUHANDAN, MAHMUT and ÇALIK, MUSTAFA and İŞCAN, AKIN} }
APA DEMİR, N , KOÇ, A , ABUHANDAN, M , ÇALIK, M , İŞCAN, A . (2015). Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency. Turkish Journal of Medical Sciences, 45 (6), 1274-1279. Retrieved from http://dergipark.org.tr/tbtkmedical/issue/12391/149011
MLA DEMİR, N , KOÇ, A , ABUHANDAN, M , ÇALIK, M , İŞCAN, A . "Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency". Turkish Journal of Medical Sciences 45 (2015): 1274-1279 <http://dergipark.org.tr/tbtkmedical/issue/12391/149011>
Chicago DEMİR, N , KOÇ, A , ABUHANDAN, M , ÇALIK, M , İŞCAN, A . "Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency". Turkish Journal of Medical Sciences 45 (2015): 1274-1279
RIS TY - JOUR T1 - Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency AU - NİHAT DEMİR , AHMET KOÇ , MAHMUT ABUHANDAN , MUSTAFA ÇALIK , AKIN İŞCAN Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1274 EP - 1279 VL - 45 IS - 6 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Medical Sciences Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency %A NİHAT DEMİR , AHMET KOÇ , MAHMUT ABUHANDAN , MUSTAFA ÇALIK , AKIN İŞCAN %T Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 6 %R %U
ISNAD DEMİR, NİHAT , KOÇ, AHMET , ABUHANDAN, MAHMUT , ÇALIK, MUSTAFA , İŞCAN, AKIN . "Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency". Turkish Journal of Medical Sciences 45 / 6 (December 2015): 1274-1279.
AMA DEMİR N , KOÇ A , ABUHANDAN M , ÇALIK M , İŞCAN A . Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency. Turkish Journal of Medical Sciences. 2015; 45(6): 1274-1279.
Vancouver DEMİR N , KOÇ A , ABUHANDAN M , ÇALIK M , İŞCAN A . Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency. Turkish Journal of Medical Sciences. 2015; 45(6): 1279-1274.