Year 2015, Volume 45, Issue 6, Pages 1280 - 1284 2015-12-04

Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency
Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency

TEKİN GÜNEY [1] , MURAT ALIŞIK [2] , SEMA AKINCI [3] , SALİM NEŞELİOĞLU [4] , İMDAT DİLEK [5] , ÖZCAN EREL [6]

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Background/aim: The aim of this study was to examine the theory that oxidative stress might have an important mediating effect on the deleterious results of vitamin B12 metabolism deficiency seen throughout the body. Materials and methods: Forty patients with vitamin B12 deficiency and 40 healthy controls were included in the study. Venous blood samples were collected from all participants to evaluate serum vitamin B12, homocysteine, methylmalonic acid, total antioxidant status (TAS), and total oxidant status (TOS) levels in the pre- and posttreatment periods. Results: There were no significant differences in TAS, TOS, or oxidative stress index (OSI) levels between the pretreatment patient and control groups, and there were no significant differences in TAS or TOS levels between the posttreatment and control groups. In addition, there were no significant differences between the pre- and posttreatment TAS, TOS, and OSI levels of the patients. Conclusion: These findings are remarkable in that cyanocobalamin treatment had no direct effect on oxidant and antioxidant status in patients with vitamin B12 deficiency. The fact that there were no differences in oxidant and antioxidant status between the patients and the controls might suggest that oxidative stress does not play a role in the systemic negative effects of vitamin B12 deficiency.
Background/aim: The aim of this study was to examine the theory that oxidative stress might have an important mediating effect on the deleterious results of vitamin B12 metabolism deficiency seen throughout the body. Materials and methods: Forty patients with vitamin B12 deficiency and 40 healthy controls were included in the study. Venous blood samples were collected from all participants to evaluate serum vitamin B12, homocysteine, methylmalonic acid, total antioxidant status (TAS), and total oxidant status (TOS) levels in the pre- and posttreatment periods. Results: There were no significant differences in TAS, TOS, or oxidative stress index (OSI) levels between the pretreatment patient and control groups, and there were no significant differences in TAS or TOS levels between the posttreatment and control groups. In addition, there were no significant differences between the pre- and posttreatment TAS, TOS, and OSI levels of the patients. Conclusion: These findings are remarkable in that cyanocobalamin treatment had no direct effect on oxidant and antioxidant status in patients with vitamin B12 deficiency. The fact that there were no differences in oxidant and antioxidant status between the patients and the controls might suggest that oxidative stress does not play a role in the systemic negative effects of vitamin B12 deficiency.
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Primary Language tr
Journal Section Articles
Authors

Author: TEKİN GÜNEY

Author: MURAT ALIŞIK

Author: SEMA AKINCI

Author: SALİM NEŞELİOĞLU

Author: İMDAT DİLEK

Author: ÖZCAN EREL

Dates

Publication Date: December 4, 2015

Bibtex @ { tbtkmedical149012, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {TUBITAK}, year = {2015}, volume = {45}, pages = {1280 - 1284}, doi = {}, title = {Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency}, key = {cite}, author = {GÜNEY, TEKİN and ALIŞIK, MURAT and AKINCI, SEMA and NEŞELİOĞLU, SALİM and DİLEK, İMDAT and EREL, ÖZCAN} }
APA GÜNEY, T , ALIŞIK, M , AKINCI, S , NEŞELİOĞLU, S , DİLEK, İ , EREL, Ö . (2015). Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency. Turkish Journal of Medical Sciences, 45 (6), 1280-1284. Retrieved from http://dergipark.org.tr/tbtkmedical/issue/12391/149012
MLA GÜNEY, T , ALIŞIK, M , AKINCI, S , NEŞELİOĞLU, S , DİLEK, İ , EREL, Ö . "Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency". Turkish Journal of Medical Sciences 45 (2015): 1280-1284 <http://dergipark.org.tr/tbtkmedical/issue/12391/149012>
Chicago GÜNEY, T , ALIŞIK, M , AKINCI, S , NEŞELİOĞLU, S , DİLEK, İ , EREL, Ö . "Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency". Turkish Journal of Medical Sciences 45 (2015): 1280-1284
RIS TY - JOUR T1 - Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency AU - TEKİN GÜNEY , MURAT ALIŞIK , SEMA AKINCI , SALİM NEŞELİOĞLU , İMDAT DİLEK , ÖZCAN EREL Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1280 EP - 1284 VL - 45 IS - 6 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Medical Sciences Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency %A TEKİN GÜNEY , MURAT ALIŞIK , SEMA AKINCI , SALİM NEŞELİOĞLU , İMDAT DİLEK , ÖZCAN EREL %T Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 6 %R %U
ISNAD GÜNEY, TEKİN , ALIŞIK, MURAT , AKINCI, SEMA , NEŞELİOĞLU, SALİM , DİLEK, İMDAT , EREL, ÖZCAN . "Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency". Turkish Journal of Medical Sciences 45 / 6 (December 2015): 1280-1284.
AMA GÜNEY T , ALIŞIK M , AKINCI S , NEŞELİOĞLU S , DİLEK İ , EREL Ö . Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency. Turkish Journal of Medical Sciences. 2015; 45(6): 1280-1284.
Vancouver GÜNEY T , ALIŞIK M , AKINCI S , NEŞELİOĞLU S , DİLEK İ , EREL Ö . Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency. Turkish Journal of Medical Sciences. 2015; 45(6): 1284-1280.