Year 2017, Volume 47, Issue 1, Pages 109 - 114 2017-02-01

Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count

KAVITHA KUMAR [1] , PRASHANT GIRIBHATTANAVAR [2] , SHRIPAD PATIL [3]

2 2

Background/aim: The role of nitric oxide (NO) has been established in infection over the years. NO functions by inhibiting the growth of intracellular pathogens. The present study was undertaken to ascertain the role of NO in central nervous system (CNS) infection by Mycobacterium tuberculosis. Materials and methods: A total of 781 chronic meningitis cerebrospinal fluid (CSF) samples suspected of CNS tuberculosis (TB) were categorized based on M. tuberculosis culture positivity, anti-TB antibody response, and CSF cell count and were analyzed for NO. Results: We found that NO levels were positive in 10.88% of the CSF samples. Positivity for NO was 18%, 11.67%, 13.68%, 9.32%, and 9.66% in the cases with mycobacterial culture positivity, anti-TB antibody positivity, high cell count, low cell count, and zero cell count, respectively. Among the above cell count categories, NO levels were noticed to be elevated in high cell count samples with mononuclear cell predominance. Conclusion: This study suggests that NO might play some role in the later stages of tuberculous meningitis. This is the first study to our knowledge in which NO was evaluated in CSF in relation to immune response and the presence of a pathogen with such a large number of subjects.
ELISA, mycobacteria, nitrite, tuberculous meningitis
Journal Section Articles
Authors

Author: KAVITHA KUMAR

Author: PRASHANT GIRIBHATTANAVAR

Author: SHRIPAD PATIL

Bibtex @ { tbtkmedical576040, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {TUBITAK}, year = {2017}, volume = {47}, pages = {109 - 114}, doi = {}, title = {Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count}, key = {cite}, author = {KUMAR, KAVITHA and GIRIBHATTANAVAR, PRASHANT and PATIL, SHRIPAD} }
APA KUMAR, K , GIRIBHATTANAVAR, P , PATIL, S . (2017). Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count. Turkish Journal of Medical Sciences, 47 (1), 109-114. Retrieved from http://dergipark.org.tr/tbtkmedical/issue/45677/576040
MLA KUMAR, K , GIRIBHATTANAVAR, P , PATIL, S . "Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count". Turkish Journal of Medical Sciences 47 (2017): 109-114 <http://dergipark.org.tr/tbtkmedical/issue/45677/576040>
Chicago KUMAR, K , GIRIBHATTANAVAR, P , PATIL, S . "Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count". Turkish Journal of Medical Sciences 47 (2017): 109-114
RIS TY - JOUR T1 - Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count AU - KAVITHA KUMAR , PRASHANT GIRIBHATTANAVAR , SHRIPAD PATIL Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 109 EP - 114 VL - 47 IS - 1 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Medical Sciences Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count %A KAVITHA KUMAR , PRASHANT GIRIBHATTANAVAR , SHRIPAD PATIL %T Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count %D 2017 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 47 %N 1 %R %U
ISNAD KUMAR, KAVITHA , GIRIBHATTANAVAR, PRASHANT , PATIL, SHRIPAD . "Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count". Turkish Journal of Medical Sciences 47 / 1 (February 2017): 109-114.