Araştırma Makalesi
BibTex RIS Kaynak Göster

Yıl 2019, Cilt: 40 Sayı: 3, 578 - 582, 30.09.2019

Ceylan Hepokur Yakup Budak Hasan Basri Karayel Bedrettin Selvi İlhan Yaylım

https://doi.org/10.17776/csj.437993
Cited By: 8

Öz

Kaynakça

  • [1] Basanagouda M., Jambagi V.B., Barigidad N.N., Laxmeshwar S.S., Devaru V. and Narayanachar M., Synthesis, Structure-activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents, European Journal of Medicinal Chemistry, 74 (2014) 225-233.
  • [2] Barrett J.M., Mechanisms of Multistep Carcinogenesis and Carcinogen Risk., Environmental Health Perspectives,100 (1993) 9-20.
  • [3] Tan W., Lu J., Huang M., Li Y., Chen M., Wu G., Gong J., Zhong Z., Xu Z., Dang Y., Guo J., Chen X. and Wang Y., Anti-cancer natural products isolated from Chinese medicinal herbs. Chinese Medicine,6 (2011) 27- 42.
  • [4] Monteiro L.S., Bastos K.X., Barbosa-Filho J.M., Athayde-Filho P.F., Diniz M.F. and Sobral M.V., Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer., Evidence-Based Complementary and Alternative Medicine, Article ID 604152 (2014) pp 15.
  • [5] Brullo S. and Marco G., Taxonomical revision of the genus Dittrichia (Asteraceae), Porttugaliae Actua Biol,19 (2000) 341-54.
  • [6] Messaoudi M., Chahmi N., El Mzibri M., Gmouh S., Amzazi S., Benbacer L. and El Hassouni M., Cytotoxic Effect and Chemical Composition of Inula viscosa from Three Different Regions of Morocco., European Journal of Medicinal Plants, 16-4 (2016) 1-9.
  • [7] Ana M.L.S., Grigore A., Diana C.G.A.P. and Artur M.S.S., The genus Inula and their metabolites: From ethnopharmacological tomedicinaluses., Journal of Ethnopharmacology, 154 (2014) 286-310.
  • [8] Su B.N.,Takaishi Y., Yabuuchi T., Kusumi T., Tori M., Takaoka S., Honda G., Ito M., Takeda Y., Kodzhimatov O. K. and Ashurmetov O. Sesquiterpenes and monoterpenes from the bark of Inula macrophylla., J. Nat. Prod., 64 (2001) 466.
  • [9] Barbetti P., Chiappini I., Fardella G. and Menghini A., A new eudesmane acid from Dittrichia (Inula) viscosa., Planta Med., 51-5 (1985) 471.
  • [10] Lauro L. and Rolih C. Observations and research on an extract of Inula viscose Ait. Boll, Soc. Ital. Biol. Sper.,66 (1990) 829-834.
  • [11] Lev E. and Amar Z. Ethnopharmacological survey of traditional drugs sold in Israel at the end of the 20th century., J. Ethnopharmacol,72 (2000) 191-205.
  • [12] Zhaoa Y., Zhanga M., Shi Q. and Kiyota H., Chemical Constituents of Plants from the Genus Inula., Chemıstry & Biodiversity, 3 (2006) 371.
  • [13] Adzu B., Balogun O.S., Sérgio E.D., Donizeti A.I., Mendes S.R., Wagner S.A., Reginaldo V.R.Â., Márcia Selhorst S.B.R., Godinhode O.L., Ireneda S.A., Sabino D.D. and Tabajara de O.M., Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms., Journal of Ethnopharmacology, 175 (2015) 378-389.
  • [14] Tanaka R., Shıma K., Taruı S. and Nıshıkawa M., Boiling Method for the Extraction of Gut Glucagon-like Immunoreactive Materials, Endocrinol. Japon, 22-6 (1975) 503-507.
  • [15] Tutar U., Celik C., Karaman I., Hepokur C. and Atas M. The anti-biofilm and antimicrobial activity of Mentha pulegium L. essential oil against multidrug-resistant Acinetobacter baumannii. Trop J Pharm Res., 15-5 (2016) 1039-1046.
  • [16] Lastra C., Lopez A. and Motilva V., Gastroprotection and prostaglandin E2 generation in rats by flavonoids of Dittrichia viscosa. Planta Med., 59-6 (1993) 497–501.
  • [17] Haoui IE., Extraction of Essential Oil from Inula viscosa (L.) Leaves: Composition, Antifungal Activity and Kinetic Data. Journal of essential oil-bearing plants, 19-1 (2016)108-118.
  • [18] Rozenblat S., Grossman S., Bergman M., Gottlieb H., Cohen Y. and Dovrat S., Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines, Biochemical Pharmacology, 75 (2008) 369-82.
  • [19] El Ouariachi E. and Bouyanzer A., Antioxidant activity of solvent extracts of Inula viscosa from Morocco, Arabian Journal of Chemical and Environmental Research, 1(2014)33-40.
  • [20] Seca A.M., Grigore A., Pinto D.C. and Silva A.M., The genus Inula and their metabolites:From ethnopharmacological to medicinal uses., J Ethnopharmacol,154-2 (2014) 286-310.
  • [21] Belayachi L., Aceves-Luquero C., Merghoub N., Bakri Y., Fernández de Mattos S., Amzazi S. and Villalonga P., Screening of North African Medicinal Plant Extracts for Cytotoxic Activity Against Tumor Cell Lines., European Journal of Medicinal Plants,3-3 (2013) 310-332.
  • [22] Dorn D.C., Alexenizer M. and Hengstler J.G. Dorn A., Tumor cell specific toxicity of Inula helenium extracts, Phytother Res., 20-11(2006)970-80.

Investigation of Cytotoxic Effects of Inula Viscosa Extract

Yıl 2019, Cilt: 40 Sayı: 3, 578 - 582, 30.09.2019

Ceylan Hepokur Yakup Budak Hasan Basri Karayel Bedrettin Selvi İlhan Yaylım

https://doi.org/10.17776/csj.437993
Cited By: 8

Öz

Inula viscosa is a type of Asteraceae
family, which widely used for
medicinal plant to treatment of different diseases. Inula viscosa contains many biological compounds, such as monoterpenes,
sesquiterpenes, diterpenes, flavonoids. Our study
aimed to investigate the cytotoxic effects of Inula viscosa extract on MCF-7 (breast carcinoma), C6 (glioblostoma
cancer), MG63 (bone osteosarcoma), cancer cells and L929 (mouse fibroblostama)
cell lines. Cytotoxic effects of the Inula
viscosa extracts were performed by XTT assay. In this study, Inula viscosa extracts showed selective
cytotoxic effect on MC-7 compared than L929 cells. The Inula
viscosa extracts appear
to be a promising source of new anticancer agent. Further studies are needed to identify the
cytotoxic activity mechanisms on these cancer cell lines.

Anahtar Kelimeler

Cancer Cytotoxic Effect

Kaynakça

  • [1] Basanagouda M., Jambagi V.B., Barigidad N.N., Laxmeshwar S.S., Devaru V. and Narayanachar M., Synthesis, Structure-activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents, European Journal of Medicinal Chemistry, 74 (2014) 225-233.
  • [2] Barrett J.M., Mechanisms of Multistep Carcinogenesis and Carcinogen Risk., Environmental Health Perspectives,100 (1993) 9-20.
  • [3] Tan W., Lu J., Huang M., Li Y., Chen M., Wu G., Gong J., Zhong Z., Xu Z., Dang Y., Guo J., Chen X. and Wang Y., Anti-cancer natural products isolated from Chinese medicinal herbs. Chinese Medicine,6 (2011) 27- 42.
  • [4] Monteiro L.S., Bastos K.X., Barbosa-Filho J.M., Athayde-Filho P.F., Diniz M.F. and Sobral M.V., Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer., Evidence-Based Complementary and Alternative Medicine, Article ID 604152 (2014) pp 15.
  • [5] Brullo S. and Marco G., Taxonomical revision of the genus Dittrichia (Asteraceae), Porttugaliae Actua Biol,19 (2000) 341-54.
  • [6] Messaoudi M., Chahmi N., El Mzibri M., Gmouh S., Amzazi S., Benbacer L. and El Hassouni M., Cytotoxic Effect and Chemical Composition of Inula viscosa from Three Different Regions of Morocco., European Journal of Medicinal Plants, 16-4 (2016) 1-9.
  • [7] Ana M.L.S., Grigore A., Diana C.G.A.P. and Artur M.S.S., The genus Inula and their metabolites: From ethnopharmacological tomedicinaluses., Journal of Ethnopharmacology, 154 (2014) 286-310.
  • [8] Su B.N.,Takaishi Y., Yabuuchi T., Kusumi T., Tori M., Takaoka S., Honda G., Ito M., Takeda Y., Kodzhimatov O. K. and Ashurmetov O. Sesquiterpenes and monoterpenes from the bark of Inula macrophylla., J. Nat. Prod., 64 (2001) 466.
  • [9] Barbetti P., Chiappini I., Fardella G. and Menghini A., A new eudesmane acid from Dittrichia (Inula) viscosa., Planta Med., 51-5 (1985) 471.
  • [10] Lauro L. and Rolih C. Observations and research on an extract of Inula viscose Ait. Boll, Soc. Ital. Biol. Sper.,66 (1990) 829-834.
  • [11] Lev E. and Amar Z. Ethnopharmacological survey of traditional drugs sold in Israel at the end of the 20th century., J. Ethnopharmacol,72 (2000) 191-205.
  • [12] Zhaoa Y., Zhanga M., Shi Q. and Kiyota H., Chemical Constituents of Plants from the Genus Inula., Chemıstry & Biodiversity, 3 (2006) 371.
  • [13] Adzu B., Balogun O.S., Sérgio E.D., Donizeti A.I., Mendes S.R., Wagner S.A., Reginaldo V.R.Â., Márcia Selhorst S.B.R., Godinhode O.L., Ireneda S.A., Sabino D.D. and Tabajara de O.M., Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms., Journal of Ethnopharmacology, 175 (2015) 378-389.
  • [14] Tanaka R., Shıma K., Taruı S. and Nıshıkawa M., Boiling Method for the Extraction of Gut Glucagon-like Immunoreactive Materials, Endocrinol. Japon, 22-6 (1975) 503-507.
  • [15] Tutar U., Celik C., Karaman I., Hepokur C. and Atas M. The anti-biofilm and antimicrobial activity of Mentha pulegium L. essential oil against multidrug-resistant Acinetobacter baumannii. Trop J Pharm Res., 15-5 (2016) 1039-1046.
  • [16] Lastra C., Lopez A. and Motilva V., Gastroprotection and prostaglandin E2 generation in rats by flavonoids of Dittrichia viscosa. Planta Med., 59-6 (1993) 497–501.
  • [17] Haoui IE., Extraction of Essential Oil from Inula viscosa (L.) Leaves: Composition, Antifungal Activity and Kinetic Data. Journal of essential oil-bearing plants, 19-1 (2016)108-118.
  • [18] Rozenblat S., Grossman S., Bergman M., Gottlieb H., Cohen Y. and Dovrat S., Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines, Biochemical Pharmacology, 75 (2008) 369-82.
  • [19] El Ouariachi E. and Bouyanzer A., Antioxidant activity of solvent extracts of Inula viscosa from Morocco, Arabian Journal of Chemical and Environmental Research, 1(2014)33-40.
  • [20] Seca A.M., Grigore A., Pinto D.C. and Silva A.M., The genus Inula and their metabolites:From ethnopharmacological to medicinal uses., J Ethnopharmacol,154-2 (2014) 286-310.
  • [21] Belayachi L., Aceves-Luquero C., Merghoub N., Bakri Y., Fernández de Mattos S., Amzazi S. and Villalonga P., Screening of North African Medicinal Plant Extracts for Cytotoxic Activity Against Tumor Cell Lines., European Journal of Medicinal Plants,3-3 (2013) 310-332.
  • [22] Dorn D.C., Alexenizer M. and Hengstler J.G. Dorn A., Tumor cell specific toxicity of Inula helenium extracts, Phytother Res., 20-11(2006)970-80.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Natural Sciences
Yazarlar

Ceylan Hepokur

Yakup Budak

Hasan Basri Karayel

Bedrettin Selvi

İlhan Yaylım

Yayımlanma Tarihi 30 Eylül 2019
Gönderilme Tarihi 28 Haziran 2018
Kabul Tarihi 2 Temmuz 2019
Yayımlandığı Sayı Yıl 2019Cilt: 40 Sayı: 3

Kaynak Göster

APA Hepokur, C., Budak, Y., Karayel, H. B., Selvi, B., vd. (2019). Investigation of Cytotoxic Effects of Inula Viscosa Extract. Cumhuriyet Science Journal, 40(3), 578-582. https://doi.org/10.17776/csj.437993

Cited By

A comprehensive review on ethnomedicinal uses, phytochemistry, toxicology, and pharmacological activities of Dittrichia viscosa (L.) Greuter
Journal of Traditional and Complementary Medicine
https://doi.org/10.1016/j.jtcme.2024.03.012
Molecular characterization of Dittrichia viscosa (L.) greuter (Asteraceae) populations revealed by ISSR markers and chloroplast (CPDNA) tRNL intron sequences
Genetika
https://doi.org/10.2298/GENSR2301217S
Apoptotic and antiproliferative effects of Inula viscosa L. water extract in the expression of microRnas on HCT 116 cell line: an in vitro study
International Journal of Environmental Health Research
https://doi.org/10.1080/09603123.2023.2197641
Inula viscosa (L.) Aiton Ethanolic Extract Inhibits the Growth of Human AGS and A549 Cancer Cell Lines
Chemistry & Biodiversity
https://doi.org/10.1002/cbdv.202200890
Antineoplastic Properties by Proapoptotic Mechanisms Induction of Inula viscosa and Its Sesquiterpene Lactones Tomentosin and Inuviscolide
Biomedicines
https://doi.org/10.3390/biomedicines10112739
Dittrichia viscosa L. Leaves: A Valuable Source of Bioactive Compounds with Multiple Pharmacological Effects
Molecules
https://doi.org/10.3390/molecules27072108
Anticancer, Antioxidant, Antimicrobial and Enzyme Inhibitory Activities of Inula aucheriana
Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi
Gülşen GÜÇLÜ
https://doi.org/10.18016/ksutarimdoga.vi.985837
Evaluation of cytotoxic and antioxidant potential of Dittrichia viscosa (L.) Greuter used in traditional medicine
Journal of Ethnopharmacology
Ece Sevgi
https://doi.org/10.1016/j.jep.2021.114211