Öz
Fotodinamik Terapi (FDT), kanser tedavisinde lokal olarak kullanılan ve |
Anahtar Kelimeler
Teşekkür
Boğaziçi Üniversitesi Biyomedikal Mühendisliği Enstitüsü Öğretim Üyesi Prof. Dr. Murat Gülsoy’a Biyofotonik Laboratuvarı ve Doç.Dr. Bora Garipcan’a Hücre Kültürü Laboratuvarı imkanlarından faydalanmamı sağladıkları için teşekkür ederim.
Kaynakça
- 1.Oniszczuk, A., Wojtunik-Kulesza, K.A., Oniszczuk, T., Kasprzak, K. 2016. “The potential of photodynamic therapy (PDT)—Experimental investigations and clinical use”, Biomedicine and Pharmacotherapy, 83: 912-929.
- 2. Topaloğlu, N., Güney, M., Aysan, N.,Gülsoy, M., 2015. “The role of reactive oxygen species in the bacterial phtodynamic treatment: photoinactivation vs proliferation”, Letters in Applied Microbiology, 62(3):230-236.
- 3. Zecha, J.A.E.M., Raber-Durlacher, J.E., Nair, R.G., Epstein, J.B., Elad, S., Hamblin, M.R., Barasch, A., Migliorati, C.A., Milstein, D.M.J., Genot, M-T., Lansaat, L., van der Brink, R., Arnabat-Dominguez, J., van der Molen, L., Jacobi, I., van Diessen, J., de Lange, J., Smeele, L.E., Schubert, M.M., Bensadoun, R-J. 2016. “Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols” Supportive Care in Cancer, 24 (6):2781-2792.
- 4. Yu, W., Wang, Y., Wang, J., Fang, W., Xia, K., Shao, J., Wu, M.,Liu, B., Liang, C., Ye, C., Tao, H., 2017. “A review and Outlook in the treatment osteosarcoma and other deep tumors with photodynamic therapy: from basic to deep” Oncotarget, 13 (24): 39833-39848.
- 5. Posten, W., Wrone, D., Dover, J., Arndt, K, Silapunt, S., Alam, M., 2005. “low level Laser therapy for wound healing”, Dermatologic Surgery, 31(3):334-340.
- 6. Schartinger, V.H., Galvan, O., Riechelmann, H., Duda, J., 2012. “Differential responses of fibroblasts, non-neoplastic epithelial cells, and oral carcinoma cells to low-level laser therapy” Supportive Care in Cancer, 20 (3): 523-529.
- 7. AlGhamdi, K.M., Kumar, A., Moussa, N.A., 2012. “Low-level laser therapy: A useful technique for enhancing the proliferation of various cultured cells”, Lasers in Medical Science, 27 (1): 237-249.
- 8. Xu, D., Ke, Y., Jiang, X., Cai, Y., Peng, Y., Li, Y., 2010. “In vitro photodynamic therapy on human U251 glioma cells with a novel photosensitizer ZnPcS4-BSA”. British Journal of Neurosurgery, 24, 660-665.
- 9. Ottaviani, G., Martinelli, V., Rupel, K., Caronni, N., Naseem, A., Zandonà, L, Perinetti, G., Gobbo, M., Di Lenarda, R., Bussani, R., Benvenuti, F., Giacca, M., Biasotto, M., Zacchigna, S., 2016. “Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization” EBioMedicine., 11:165-172. doi: 10.1016/j.ebiom.2016.07.028.
- 10. Dastanpour, S., Beitollahi, J.M., Saber, K., 2015. “The effect of Low-level Laser threapy on Human Leukemic Cells”, J Lasers Med Sci., 6(2): 74-79.
Öz
Photodynamic
Therapy (PDT) is a non-invasive method with minimal side effects in the
treatment of cancer. The photosensitizing agent, one of the FDT components,
stimulates the generation of reactive oxygen species and / or singlet oxygen
radicals in cancer cells with light that is at appropriate wavelength. The
light source and the photosensitizing agent alone are reported to have no toxic
effect. However, in some of the studies, there are also reports that only laser
applications can have effects on cell lines. For this purpose, effects of the
808 nm laser light source at 50 J/cm2, 100 J/cm2 and 150
J/cm2 were investigated DNA synthesis of C6 glioma, Caco-2 colon
cancer, L929 fibroblast and prostate cancer PC-3 cell that are frequently
studied. It was found that except for Caco-2 cells, laser application decreased
DNA synthesis in all other cell lines at 24 hours, but this effect was maintained
at other hours. As a result, although laser application may have effects on DNA
synthesis at short time depending on the dose and cell line used, these effects
should be investigated in the context of other cellular mechanisms.
Anahtar Kelimeler
Kaynakça
- 1.Oniszczuk, A., Wojtunik-Kulesza, K.A., Oniszczuk, T., Kasprzak, K. 2016. “The potential of photodynamic therapy (PDT)—Experimental investigations and clinical use”, Biomedicine and Pharmacotherapy, 83: 912-929.
- 2. Topaloğlu, N., Güney, M., Aysan, N.,Gülsoy, M., 2015. “The role of reactive oxygen species in the bacterial phtodynamic treatment: photoinactivation vs proliferation”, Letters in Applied Microbiology, 62(3):230-236.
- 3. Zecha, J.A.E.M., Raber-Durlacher, J.E., Nair, R.G., Epstein, J.B., Elad, S., Hamblin, M.R., Barasch, A., Migliorati, C.A., Milstein, D.M.J., Genot, M-T., Lansaat, L., van der Brink, R., Arnabat-Dominguez, J., van der Molen, L., Jacobi, I., van Diessen, J., de Lange, J., Smeele, L.E., Schubert, M.M., Bensadoun, R-J. 2016. “Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols” Supportive Care in Cancer, 24 (6):2781-2792.
- 4. Yu, W., Wang, Y., Wang, J., Fang, W., Xia, K., Shao, J., Wu, M.,Liu, B., Liang, C., Ye, C., Tao, H., 2017. “A review and Outlook in the treatment osteosarcoma and other deep tumors with photodynamic therapy: from basic to deep” Oncotarget, 13 (24): 39833-39848.
- 5. Posten, W., Wrone, D., Dover, J., Arndt, K, Silapunt, S., Alam, M., 2005. “low level Laser therapy for wound healing”, Dermatologic Surgery, 31(3):334-340.
- 6. Schartinger, V.H., Galvan, O., Riechelmann, H., Duda, J., 2012. “Differential responses of fibroblasts, non-neoplastic epithelial cells, and oral carcinoma cells to low-level laser therapy” Supportive Care in Cancer, 20 (3): 523-529.
- 7. AlGhamdi, K.M., Kumar, A., Moussa, N.A., 2012. “Low-level laser therapy: A useful technique for enhancing the proliferation of various cultured cells”, Lasers in Medical Science, 27 (1): 237-249.
- 8. Xu, D., Ke, Y., Jiang, X., Cai, Y., Peng, Y., Li, Y., 2010. “In vitro photodynamic therapy on human U251 glioma cells with a novel photosensitizer ZnPcS4-BSA”. British Journal of Neurosurgery, 24, 660-665.
- 9. Ottaviani, G., Martinelli, V., Rupel, K., Caronni, N., Naseem, A., Zandonà, L, Perinetti, G., Gobbo, M., Di Lenarda, R., Bussani, R., Benvenuti, F., Giacca, M., Biasotto, M., Zacchigna, S., 2016. “Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization” EBioMedicine., 11:165-172. doi: 10.1016/j.ebiom.2016.07.028.
- 10. Dastanpour, S., Beitollahi, J.M., Saber, K., 2015. “The effect of Low-level Laser threapy on Human Leukemic Cells”, J Lasers Med Sci., 6(2): 74-79.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Mühendislik |
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Aralık 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 12 Sayı: 3 |