Derleme
Yıl 2020,
Ağız Kanserleri Özel Sayısı, 229 - 232, 28.09.2020
Öz
Squamous cell carcinoma (SCC) that constitutes a large part of oral cancers is an important cause of cancer morbidity and mortality, and can be seen in various oral sites. The aim of this study is to report clinical and radiographic features, treatment modalities of oral SCC by evaluating current literature.Articles published as case reports in Pubmed database in last 5 years of oral SCC have been searched. Articles with insufficient information about cases were excluded. Age and gender of patients, region of tumor, clinical and radiographic findings, TNM stage, treatment methods and prognosis were analyzed.Information of 78 patients (36 females, 42 males) from 68 articles were evaluated. The most detected tumor regions in oral cavity were gingiva (33.3%), tongue (23.1%), mandibular bone (21.8%) and buccal mucosa (15.4%) respectively. The most common sign in patients was ulceration (42.3%), and the most common symptom was pain (41%). Stage 3 (34.5%) and Stage 4 (36,4%) TNM stages were mostly observed.In our study, it was determined that the majority of cases of oral SCC were diagnosed in late stages. Due to the poor prognosis of oral cancers, early diagnosis has a great importance for the treatment and quality of life of the patient. For this reason, raising awareness about oral cancer and risk factors, and performing routine oral examinations were very important for the early diagnosis of SCC.
Anahtar Kelimeler
Squamous Cell Carcinoma Mouth Neoplasms Risk Factors Early Detection of Cancer
Kaynakça
- Boyle P, Macfarlane GJ, Maisonneuve P et al. Epidemiology of mouth cancer in 1989: a review. Journal of the Royal Society of Medicine. 1990;83.11:724-30.
- Moore, SR, Johnson NW, Pierce AM et al. The epidemiology of mouth cancer: a review of global incidence. Oral Diseases. 2000;6.2:65-74.
- Ko YC, Huang, YL, Lee CH et al. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. Journal Of Oral Pathology & Medicine. 1995;24.10: 450-3.
- Silverman Jr S, Gorsky M, Greenspan D. Tobacco usage in patients with head and neck carcinoma: a follow-up study on habit changes and second primary oral oropharyngeal cancers. J Am Dent Assoc. 1983;106:33.
- Mashberg A, Garfinkel L, Harris S. Alcohol as a primary risk factor in oral squamous carcinoma. CA: A Cancer Journal For Clinicians. 1981;31.3:146-55.
- Gorsky M, Littner MM, Sukman Y et al. The prevalence of oral cancer in relation to the ethnic origin of Israeli Jews. Oral Surgery, Oral Medicine, Oral Pathology. 1994;78.3:408-11.
- Chen YK, Huang HC, Lin LM et al. Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan. Oral Oncology, 1999;35.2:173-9.
- Al-Rawi NH, Talabani NG. Squamous cell carcinoma of the oral cavity: a case series analysis of clinical presentation and histological grading of 1,425 cases from Iraq. Clinical Oral İnvestigations. 2008;12.1:15-8.
- Warnakulasuriya KAAS, Johnson NW. Sensitivity and specificity of OraScan® toluidine blue mouthrinse in the detection of oral cancer and precancer. Journal Of Oral Pathology & Medicine. 1996;25.3:97-103.
- Warnakulasuriya S. Causes of oral cancer–an appraisal of controversies. British Dental Journal. 2009;207.10:471-5.
- Shiboski CH, Schmidt B, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the US population ages 20–44 years. Cancer. 2005;103.9:1843-9.
- McGorray SP, Guo Y, Logan H. Trends in incidence of oral and pharyngeal carcinoma in Florida: 1981‐2008. Journal Of Public Health Dentistry. 2012;72.1:68-74.
- Arduino PG, Carrozzo M, Chiecchio A et al. Clinical and histopathologic independent prognostic factors in oral squamous cell carcinoma: a retrospective study of 334 cases. Journal Of Oral And Maxillofacial Surgery. 2008;66.8:1570-9.
- Oliver AJ, Helfrick JF, Gard D. Primary oral squamous cell carcinoma: a review of 92 cases. Journal Of Oral And Maxillofacial Surgery. 1996;54.8:949-54.
- Silverman Jr S, Gorsky M. Epidemiologic and demographic update in oral cancer: California and national data—1973 to 1985. The Journal of the American Dental Association. 1990;20.5:495-9.
- Heng C, Rossi EP. A report on 222 cases of oral squamous cell carcinoma. Military medicine. 1995;160.7:319-23.
- Wildt J, Bundgaard T, Bentzen SM. Delay in the diagnosis of oral squamous cell carcinoma. Clinical Otolaryngology & Allied Sciences. 1995;20.1:21-5.
- Pinholt EM, Rindum J, Pindborg JJ. Oral cancer: A retrospective study of 100 Danish cases. Br J Oral Maxillofac Surg. 1997;35:77-80.
- Chandu A, Adams G, Smith AC. Factors affecting survival in patients with oral cancer: an Australian perspective. International Journal Of Oral And Maxillofacial Surgery, 2005;34.5:514-20.
- Németh Z, Velich N, Bogdan S et al. The prognostic role of clinical, morphological and molecular markers in oral squamous cell tumors. Neoplasma, 2005;52.2:95-102.
- Kurokawa H, Zhang M, Matsumoto S et al. The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinoma. Journal Of Oral Pathology & Medicine. 2005;34.6:329-33.
Yıl 2020,
Ağız Kanserleri Özel Sayısı, 229 - 232, 28.09.2020
Öz
Ağız kanserlerinin büyük bir kısmını oluşturan oral skuamöz hücreli karsinom (SHK) kanser morbidite ve mortalitesinin önemli bir nedenidir ve ağız içinde çeşitli bölgelerde gözlenebilir. Bu çalışmanın amacı güncel literatürü değerlendirerek oral SHK`nın klinik ve radyografik özelliklerini, tedavi yöntemlerini bildirmektir.Pubmed veri tabanında oral SHK`lara ait son 5 yıl içerisinde olgu sunumu olarak yayınlanmış makaleler araştırıldı. Vakalarla ilgili yetersiz bilgi bulunan makaleler inceleme dışı bırakıldı. Hastaların yaşı, cinsiyeti, tümörün bulunduğu bölge, klinik ve radyografik bulgular, TNM evresi ile tedavi şekilleri ve prognoz analiz edildi.68 makaleye ait 78 hastanın bilgileri (36 kadın, 42 erkek) değerlendirildi. SHK, oral kavitede sırasıyla en sık gingiva (% 33,3), dil (% 23,1), mandibular kemik (% 21,8) ve bukkal mukozada (% 15,4) gözlendi. Hastalarda en sık rastlanan bulgu ülserasyon (% 42,3), en sık rastlanan belirti ise ağrıydı (% 41). Olguların TNM evreleri değerlendirildiğinde çoğunlukla 3. (% 34,5) ve 4. (% 36,4) evrede teşhis koyulduğu belirlendi.Çalışmamızda oral SHK olgularının çoğunun geç evrede teşhis edildiği belirlendi. Ağız kanserlerinin prognozunun kötü olması nedeniyle, erken teşhis hastanın tedavisi ve yaşam kalitesi açısından büyük önem taşımaktadır. Bu nedenle toplumun ağız kanseri ve risk faktörleri açısından bilinçlendirilmesi ve rutin oral muayenelerinin yapılması SHK`nın erken teşhisi açısından önemlidir.
Anahtar Kelimeler
Skuamöz hücreli karsinom ağız neoplazileri Risk faktörleri kanserin erken tespiti
Kaynakça
- Boyle P, Macfarlane GJ, Maisonneuve P et al. Epidemiology of mouth cancer in 1989: a review. Journal of the Royal Society of Medicine. 1990;83.11:724-30.
- Moore, SR, Johnson NW, Pierce AM et al. The epidemiology of mouth cancer: a review of global incidence. Oral Diseases. 2000;6.2:65-74.
- Ko YC, Huang, YL, Lee CH et al. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. Journal Of Oral Pathology & Medicine. 1995;24.10: 450-3.
- Silverman Jr S, Gorsky M, Greenspan D. Tobacco usage in patients with head and neck carcinoma: a follow-up study on habit changes and second primary oral oropharyngeal cancers. J Am Dent Assoc. 1983;106:33.
- Mashberg A, Garfinkel L, Harris S. Alcohol as a primary risk factor in oral squamous carcinoma. CA: A Cancer Journal For Clinicians. 1981;31.3:146-55.
- Gorsky M, Littner MM, Sukman Y et al. The prevalence of oral cancer in relation to the ethnic origin of Israeli Jews. Oral Surgery, Oral Medicine, Oral Pathology. 1994;78.3:408-11.
- Chen YK, Huang HC, Lin LM et al. Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan. Oral Oncology, 1999;35.2:173-9.
- Al-Rawi NH, Talabani NG. Squamous cell carcinoma of the oral cavity: a case series analysis of clinical presentation and histological grading of 1,425 cases from Iraq. Clinical Oral İnvestigations. 2008;12.1:15-8.
- Warnakulasuriya KAAS, Johnson NW. Sensitivity and specificity of OraScan® toluidine blue mouthrinse in the detection of oral cancer and precancer. Journal Of Oral Pathology & Medicine. 1996;25.3:97-103.
- Warnakulasuriya S. Causes of oral cancer–an appraisal of controversies. British Dental Journal. 2009;207.10:471-5.
- Shiboski CH, Schmidt B, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the US population ages 20–44 years. Cancer. 2005;103.9:1843-9.
- McGorray SP, Guo Y, Logan H. Trends in incidence of oral and pharyngeal carcinoma in Florida: 1981‐2008. Journal Of Public Health Dentistry. 2012;72.1:68-74.
- Arduino PG, Carrozzo M, Chiecchio A et al. Clinical and histopathologic independent prognostic factors in oral squamous cell carcinoma: a retrospective study of 334 cases. Journal Of Oral And Maxillofacial Surgery. 2008;66.8:1570-9.
- Oliver AJ, Helfrick JF, Gard D. Primary oral squamous cell carcinoma: a review of 92 cases. Journal Of Oral And Maxillofacial Surgery. 1996;54.8:949-54.
- Silverman Jr S, Gorsky M. Epidemiologic and demographic update in oral cancer: California and national data—1973 to 1985. The Journal of the American Dental Association. 1990;20.5:495-9.
- Heng C, Rossi EP. A report on 222 cases of oral squamous cell carcinoma. Military medicine. 1995;160.7:319-23.
- Wildt J, Bundgaard T, Bentzen SM. Delay in the diagnosis of oral squamous cell carcinoma. Clinical Otolaryngology & Allied Sciences. 1995;20.1:21-5.
- Pinholt EM, Rindum J, Pindborg JJ. Oral cancer: A retrospective study of 100 Danish cases. Br J Oral Maxillofac Surg. 1997;35:77-80.
- Chandu A, Adams G, Smith AC. Factors affecting survival in patients with oral cancer: an Australian perspective. International Journal Of Oral And Maxillofacial Surgery, 2005;34.5:514-20.
- Németh Z, Velich N, Bogdan S et al. The prognostic role of clinical, morphological and molecular markers in oral squamous cell tumors. Neoplasma, 2005;52.2:95-102.
- Kurokawa H, Zhang M, Matsumoto S et al. The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinoma. Journal Of Oral Pathology & Medicine. 2005;34.6:329-33.
Toplam 21 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | DERLEMELER / REVIEWS |
| Yazarlar | |
| Yayımlanma Tarihi | 28 Eylül 2020 |
| Yayımlandığı Sayı | Yıl 2020 Ağız Kanserleri Özel Sayısı |