Araştırma Makalesi
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Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma

Yıl 2019, Cilt: 4 Sayı: 3, 85 - 88, 31.12.2019

Huseyin Avni Eroglu Sunay Sibel Karayol Bulent Guvendi Yasemen Adali

https://doi.org/10.22391/fppc.518251
Cited By: 1

Öz



Introduction: Due to the well-known
relationship between inflammatory processes and carcinogenesis, the diagnostic
and prognostic value of systemic inflammatory markers are at the focus of
research. This study aimed to investigate the predictive value of inflammatory
cell data obtained from complete blood count in incidentally detected thyroid
papillary carcinoma.



Methods: A total of 100 cases were
included in the study, consisting of histopathologically diagnosed multinodular
hyperplasia (MNH) (N = 20), lymphocytic thyroiditis (LT) (n = 20), incidental
thyroid papillary carcinoma (ITPC) (n = 20), incidental papillary carcinoma and
lymphocytic thyroiditis (ITPCLT) (n = 20), and thyroid papillary carcinoma
(TPC) (n = 20). Neutrophil / lymphocyte ratio (NLR), platelet/ lymphocyte ratio
(PLR), platelet/neutrophil ratio (PNR), lymphocyte/ monocyte ratio (LMR) and
lymphocyte/ eosinophil ratio (LER) values were compared between the groups.



Results: No significant difference
was detected between the groups concerning the mean inflammatory cell and
platelet values. However, statistical significance was observed between the
ITPC and ITPCLT groups regarding the mean LMR and LER values (p=0.009 and
p=0.037, respectively). Higher LMR was found in the ITPC group, while higher
LER was seen in the ITPCLT group.



Conclusions: We suggest that besides
ratios such as NLR and PLR used as systemic inflammatory markers in carcinogenetic
processes, the evaluation of LER and LMR might be imperative as well.
Therefore, these potential markers should be studied in bigger series of
tumors, especially where inflammatory processes are involved in the etiology.



Anahtar Kelimeler

Thyroid cancer papillary carcinoma lymphocytes eosinophils monocytes neutrophils

Teşekkür

We thank Dr. Tugba Toyran for helping in data collection.

Kaynakça

  • 1. Bombil I, Bentley A, Kruger D, Luvhengo TE. Incidental cancer in multinodular goiter post thyroidectomy. S Afr J Surg 2014;52(1):5-9. https://www.ncbi.nlm.nih.gov/pubmed/24881131
  • 2. Miccoli P, Minuto MN, Galleri D, D'Agostino J, Basolo F, Antonangeli L, et al. Incidental thyroid carcinoma in a large series of consecutive patients operated on for benign thyroid disease. ANZ J Surg 2006;76(3):123-6. 10.1111/j.1445-2197.2006.03667.x
  • 3. Kaliszewski K, Diakowska D, Strutyńska-Karpińska M, Wojtczak B, Domosławski P, Balcerzak W. Clinical and histopathological characteristics of patients with incidental and no incidental thyroid cancer. Arch Med Sci 2017;13(2):390-5. 10.5114/aoms.2016.59579
  • 4. Woolner LB, Lemmon M, Beahrs OH, Black M, Keating FR. Occult papillary carcinoma of the thyroid gland: a study of 140 cases observed in a 30 year period. J Clin Endocrinol 1960;20:89-105. 10.1210/jcem-20-1-89
  • 5. Bozkurt K, Sert Bektas S. The prevalence of thyroid cancers in surgically treated patients with nodular goiter in Şırnak city. Dicle Med J 2010;37(4):363-6. https://dergipark.org.tr/tr/download/article-file/54055
  • 6. Cakir M, Arici C, Alakus H, Altunbas H, Balci MK, Karayalcin U. Incidental thyroid carcinoma in thyrotoxic patients treated by surgery. Horm Res 2007;67(2):96-9. https://doi.org/10.1159/000096357
  • 7. Gokce AH, Eren A, Gokce FS, Cay T, Bozkurt E, Celik G, et al. The incidence of throid cancer in multinodular goiter. IMJ 2008:1:70-72. http://cms.galenos.com.tr/Uploads/Article_21344/IMJ-9-70-En.pdf
  • 8. Salciccioli JD, Marshall DC, Pimente lMAF, Santos MD, Pollard T, Celi LA, et al. The associa¬tion between the neutrophil-to-lymphocyte ratio and mortality in critical illness: an observational cohort study. Crit Care 2015;19:13. 10.1186/s13054-014-0731-6
  • 9. Chun S, Shin K, Kim KH, Kim HY, Eo W, Lee JY, et al. The neutrophil-Lymphocyte ratio predicts recurrence of cervical intraepithelial neoplasia. J Cancer 2017;8(12):2205-11. 10.7150/jca.19173
  • 10. Yildirim MA, Seckin KD, Togrul C, Baser E, Karsli MF, Gungor T, et al. Roles of neutrophil/lymphocyte and platelet/lymphocyte ratios in the early diagnosis of malignant ovarian masses. Asian Pac J Cancer Prev 2014;15(16):6881-5 10.7314/apjcp.2014.15.16.6881
  • 11. Stotz M, Gerger A, Eisner F, Szkandera J, Loibner H, Ress AL, et al. Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer. Br J Cancer 2013;109(2):416-21. 10.1038/bjc.2013.332
  • 12. Ozmen S, Timur O, Calik I, Altinkaynak K, Simsek E, Gozcu H, et al. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be superior to C-reactive protein (CRP) for predicting the occurrence of differentiated thyroid cancer. Endocr Regul 2017;51(3):131-6. 10.1515/enr-2017-0013
  • 13. Baldane S, Ipekci SH, Sozen M, et al. Mean platelet volume could be a possible biomarker for papillary thyroid carcinomas. Asian Pac J Cancer Prev 2015;16(7):2671-4. 10.7314/apjcp.2015.16.7.2671
  • 14. Kocer D, Karakukcu C, Karaman H, Gokay F, Bayram F. May the neutrophil/lymphocyte ratio be a predictor in the differentiation of different thyroid disorders? Asian Pac J Cancer Prev 2015;16(9):3875-9. 10.7314/apjcp.2015.16.9.3875
  • 15. Gong W, Yang S, Yang X, Guo F. Blood preoperative neutrophil-to-lymphocyte ratio is correlated with TNM stage in patients with papillary thyroid cancer. Clinics (Sao Paulo). 2016;1(6):311-4. 10.6061/clinics/2016(06)04
  • 16. Kim EY, Kim WG, Kim WB, Kim TY, Kim JM, Ryu JS, et al. Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma. Clin Endocrinol (Oxf) 2009;71(4):581-6. 10.1111/j.1365-2265.2009.03537.x
  • 17. Nozawa H, Chiu C, Hanahan D. Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci 2006;103(33):12493–8. 10.1073/pnas.0601807103
  • 18. Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol 2013;88:218–30. 10.1016/j.critrevonc.2013.03.010
  • 19. Seretis C, Gourgiotis S, Gemenetzis G, Seretis F, Lagoudianakis E, Dimitrakopoulos G. The significance of neutrophil/ lymphocyte ratio as a possible marker of underlying papillary microcarcinoma in thyroidal goiters: a pilot study. Am J Surg 2013;205:691–6. 10.1016/j.amjsurg.2012.08.006
  • 20. Liu CL, Lee JJ, Liu TP, Chang YC, Hsu YC, Cheng SP. Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer. J Surg Oncol 2013;107:493–7. 10.1002/jso.23270
  • 21. Kim JY, Park T, Jeong SH, Jeong CY, Ju YT, Lee YJ, et al. Prognostic importance of baseline neutrophil to lymphocyte ratio in patients with advanced papillary thyroid carcinomas. Endocrine 2014;46:526–31. 10.1007/s12020-013-0089-6
  • 22. Machairas N, Kostakis ID, Prodromidou A, Stamopoulos P, Feretis T, Garoufalia Z, et al. Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions. Endocr Res 2017;42(4):311-7. 10.1080/07435800.2017.1319859
  • 23. Yaylaci S, Tosun O, Sahin O, Genc AB, Aydin E, Demiral G, et al. Lack of variation in inflammatory hematological parameters between benign nodular goiter and papillary thyroid cancer. Asian Pac J Cancer Prev 2016;17(4):2321-3. 10.7314/apjcp.2016.17.4.2321

İnsidental tiroid papiller karsinomda enflamatuar hücre oranlarının prediktif değeri

Yıl 2019, Cilt: 4 Sayı: 3, 85 - 88, 31.12.2019

Huseyin Avni Eroglu Sunay Sibel Karayol Bulent Guvendi Yasemen Adali

https://doi.org/10.22391/fppc.518251
Cited By: 1

Öz



Giriş: İnflamatuvar süreçlerin karsinogenetik süreçler
ile ilişkisi bilinmekte ve sistemik inflamatuvar belirteçlerin tanısal ve
prognostik değeri araştırılmaktadır. Bu çalışmada insidental olarak saptanan
tiroid papiller karsinomlarda tam kan sayımından elde edilen inflamatuvar hücre
verilerinin prediktif değerini araştırmak amaçlanmıştır.



Yöntem:
Histopatolojik tanıları multinodüler hiperplazi (MNH) (n=20), lenfositik
tiroidit (LT) (n=20), insidental tiroid papiller karsinom (İTPK) (n=20),
insidental papiller karsinom ve lenfositik tiroidit (İTPKLT) (n=20) ve tiroid
papiller karsinom (TPK) (n=20) olmak üzere toplam 100 olgu çalışmaya dahil
edildi. Olguların nötrofil/ lenfosit oranı (NLO), platelet lenfosit oranı
(PLO), platelet/ nötrofil oranı (PNO), lenfosit monosit oranı (LMO) ve lenfosit
eozinofil oranı (LEO) değerleri gruplar arasında karşılaştırıldı.



Bulgular:
İnflamatuvar hücre ortalamaları ve platelet verileri incelendiğinde gruplar
arasında bariz farklılık dikkati çekmedi. 
İnsidental tiroid papiller karsinom ile yapılan analizlerde İTPKLT grubu
ile arasında LMO ve LEO açısından belirgin istatistiksel anlamlılık gözlendi (p
değerleri sırası ile 0,009 ve 0,037). Buna göre LMO İTPK'da yüksek, LEO ise
İTPKLT grubunda yüksek saptandı.



Sonuç:
İnflamatuvar hücrelere dair karsinogenetik süreçlerde salt sistemik
inflamatuvar belirteçler olarak kullanılan NLR, PLR gibi oranların değil LEO ve
LMO gibi oranlarında değerlendirilmesinin gelecekte önem arz edebileceğini ve
bu nedenle özellikle inflamatuvar süreçlerin etyolojide yer aldığı tümörlerde
geniş olgu serilerinde incelenmesi gerektiğini düşünmekteyiz. 



Anahtar Kelimeler

Tiroid Kanseri papiler karsinom lenfosit eozinofil monosit nötrofil

Kaynakça

  • 1. Bombil I, Bentley A, Kruger D, Luvhengo TE. Incidental cancer in multinodular goiter post thyroidectomy. S Afr J Surg 2014;52(1):5-9. https://www.ncbi.nlm.nih.gov/pubmed/24881131
  • 2. Miccoli P, Minuto MN, Galleri D, D'Agostino J, Basolo F, Antonangeli L, et al. Incidental thyroid carcinoma in a large series of consecutive patients operated on for benign thyroid disease. ANZ J Surg 2006;76(3):123-6. 10.1111/j.1445-2197.2006.03667.x
  • 3. Kaliszewski K, Diakowska D, Strutyńska-Karpińska M, Wojtczak B, Domosławski P, Balcerzak W. Clinical and histopathological characteristics of patients with incidental and no incidental thyroid cancer. Arch Med Sci 2017;13(2):390-5. 10.5114/aoms.2016.59579
  • 4. Woolner LB, Lemmon M, Beahrs OH, Black M, Keating FR. Occult papillary carcinoma of the thyroid gland: a study of 140 cases observed in a 30 year period. J Clin Endocrinol 1960;20:89-105. 10.1210/jcem-20-1-89
  • 5. Bozkurt K, Sert Bektas S. The prevalence of thyroid cancers in surgically treated patients with nodular goiter in Şırnak city. Dicle Med J 2010;37(4):363-6. https://dergipark.org.tr/tr/download/article-file/54055
  • 6. Cakir M, Arici C, Alakus H, Altunbas H, Balci MK, Karayalcin U. Incidental thyroid carcinoma in thyrotoxic patients treated by surgery. Horm Res 2007;67(2):96-9. https://doi.org/10.1159/000096357
  • 7. Gokce AH, Eren A, Gokce FS, Cay T, Bozkurt E, Celik G, et al. The incidence of throid cancer in multinodular goiter. IMJ 2008:1:70-72. http://cms.galenos.com.tr/Uploads/Article_21344/IMJ-9-70-En.pdf
  • 8. Salciccioli JD, Marshall DC, Pimente lMAF, Santos MD, Pollard T, Celi LA, et al. The associa¬tion between the neutrophil-to-lymphocyte ratio and mortality in critical illness: an observational cohort study. Crit Care 2015;19:13. 10.1186/s13054-014-0731-6
  • 9. Chun S, Shin K, Kim KH, Kim HY, Eo W, Lee JY, et al. The neutrophil-Lymphocyte ratio predicts recurrence of cervical intraepithelial neoplasia. J Cancer 2017;8(12):2205-11. 10.7150/jca.19173
  • 10. Yildirim MA, Seckin KD, Togrul C, Baser E, Karsli MF, Gungor T, et al. Roles of neutrophil/lymphocyte and platelet/lymphocyte ratios in the early diagnosis of malignant ovarian masses. Asian Pac J Cancer Prev 2014;15(16):6881-5 10.7314/apjcp.2014.15.16.6881
  • 11. Stotz M, Gerger A, Eisner F, Szkandera J, Loibner H, Ress AL, et al. Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer. Br J Cancer 2013;109(2):416-21. 10.1038/bjc.2013.332
  • 12. Ozmen S, Timur O, Calik I, Altinkaynak K, Simsek E, Gozcu H, et al. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be superior to C-reactive protein (CRP) for predicting the occurrence of differentiated thyroid cancer. Endocr Regul 2017;51(3):131-6. 10.1515/enr-2017-0013
  • 13. Baldane S, Ipekci SH, Sozen M, et al. Mean platelet volume could be a possible biomarker for papillary thyroid carcinomas. Asian Pac J Cancer Prev 2015;16(7):2671-4. 10.7314/apjcp.2015.16.7.2671
  • 14. Kocer D, Karakukcu C, Karaman H, Gokay F, Bayram F. May the neutrophil/lymphocyte ratio be a predictor in the differentiation of different thyroid disorders? Asian Pac J Cancer Prev 2015;16(9):3875-9. 10.7314/apjcp.2015.16.9.3875
  • 15. Gong W, Yang S, Yang X, Guo F. Blood preoperative neutrophil-to-lymphocyte ratio is correlated with TNM stage in patients with papillary thyroid cancer. Clinics (Sao Paulo). 2016;1(6):311-4. 10.6061/clinics/2016(06)04
  • 16. Kim EY, Kim WG, Kim WB, Kim TY, Kim JM, Ryu JS, et al. Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma. Clin Endocrinol (Oxf) 2009;71(4):581-6. 10.1111/j.1365-2265.2009.03537.x
  • 17. Nozawa H, Chiu C, Hanahan D. Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci 2006;103(33):12493–8. 10.1073/pnas.0601807103
  • 18. Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol 2013;88:218–30. 10.1016/j.critrevonc.2013.03.010
  • 19. Seretis C, Gourgiotis S, Gemenetzis G, Seretis F, Lagoudianakis E, Dimitrakopoulos G. The significance of neutrophil/ lymphocyte ratio as a possible marker of underlying papillary microcarcinoma in thyroidal goiters: a pilot study. Am J Surg 2013;205:691–6. 10.1016/j.amjsurg.2012.08.006
  • 20. Liu CL, Lee JJ, Liu TP, Chang YC, Hsu YC, Cheng SP. Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer. J Surg Oncol 2013;107:493–7. 10.1002/jso.23270
  • 21. Kim JY, Park T, Jeong SH, Jeong CY, Ju YT, Lee YJ, et al. Prognostic importance of baseline neutrophil to lymphocyte ratio in patients with advanced papillary thyroid carcinomas. Endocrine 2014;46:526–31. 10.1007/s12020-013-0089-6
  • 22. Machairas N, Kostakis ID, Prodromidou A, Stamopoulos P, Feretis T, Garoufalia Z, et al. Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions. Endocr Res 2017;42(4):311-7. 10.1080/07435800.2017.1319859
  • 23. Yaylaci S, Tosun O, Sahin O, Genc AB, Aydin E, Demiral G, et al. Lack of variation in inflammatory hematological parameters between benign nodular goiter and papillary thyroid cancer. Asian Pac J Cancer Prev 2016;17(4):2321-3. 10.7314/apjcp.2016.17.4.2321
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi (Original Article)
Yazarlar

Huseyin Avni Eroglu 0000-0002-1040-3255

Sunay Sibel Karayol 0000-0002-2696-3580

Bulent Guvendi 0000-0002-0930-0443

Yasemen Adali 0000-0002-8004-7364

Yayımlanma Tarihi 31 Aralık 2019
Gönderilme Tarihi 26 Ocak 2019
Kabul Tarihi 14 Temmuz 2019
Yayımlandığı Sayı Yıl 2019Cilt: 4 Sayı: 3

Kaynak Göster

APA Eroglu, H. A., Karayol, S. S., Guvendi, B., Adali, Y. (2019). Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma. Family Practice and Palliative Care, 4(3), 85-88. https://doi.org/10.22391/fppc.518251
AMA Eroglu HA, Karayol SS, Guvendi B, Adali Y. Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma. Fam Pract Palliat Care. Aralık 2019;4(3):85-88. doi:10.22391/fppc.518251
Chicago Eroglu, Huseyin Avni, Sunay Sibel Karayol, Bulent Guvendi, ve Yasemen Adali. “Predictive Value of Inflammatory Cell Ratios in Incidental Thyroid Papillary Carcinoma”. Family Practice and Palliative Care 4, sy. 3 (Aralık 2019): 85-88. https://doi.org/10.22391/fppc.518251.
EndNote Eroglu HA, Karayol SS, Guvendi B, Adali Y (01 Aralık 2019) Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma. Family Practice and Palliative Care 4 3 85–88.
IEEE H. A. Eroglu, S. S. Karayol, B. Guvendi, ve Y. Adali, “Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma”, Fam Pract Palliat Care, c. 4, sy. 3, ss. 85–88, 2019, doi: 10.22391/fppc.518251.
ISNAD Eroglu, Huseyin Avni vd. “Predictive Value of Inflammatory Cell Ratios in Incidental Thyroid Papillary Carcinoma”. Family Practice and Palliative Care 4/3 (Aralık 2019), 85-88. https://doi.org/10.22391/fppc.518251.
JAMA Eroglu HA, Karayol SS, Guvendi B, Adali Y. Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma. Fam Pract Palliat Care. 2019;4:85–88.
MLA Eroglu, Huseyin Avni vd. “Predictive Value of Inflammatory Cell Ratios in Incidental Thyroid Papillary Carcinoma”. Family Practice and Palliative Care, c. 4, sy. 3, 2019, ss. 85-88, doi:10.22391/fppc.518251.
Vancouver Eroglu HA, Karayol SS, Guvendi B, Adali Y. Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma. Fam Pract Palliat Care. 2019;4(3):85-8.

Cited By

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Turkish Journal of Internal Medicine
https://doi.org/10.46310/tjim.898205

Family Practice and Palliative Care      ISSN 2458-8865       E-ISSN 2459-1505