Trombolitik Tedavinin İskemik İnme Sonrası Motor Fonksiyon Kaybı Üzerindeki Terapötik Etkisi: Bir Vaka Çalışması
Öz
İnme, doğru zamanda uygun tedavi yöntemleri ile tedavi edilmediği takdirde sakatlık ve ölüme neden olabilen ciddi bir serebrovasküler hastalıktır. İskemik inmede, rekombinant doku plazminojen aktivatörü (rt-PA) tedavisi, özellikle ilk 4,5 saatte motor fonksiyon bozukluğunun iyileşmesinde etkilidir. Bu vaka çalışmasında, akut iskemik inme sonrası motor fonksiyon kaybı olan 58 ve 79 yaşlarındaki hastaların rt-PA trombolitik tedavisinin motor fonksiyon kaybını iyileştirdiği bulunmuştur.
Anahtar Kelimeler
Etik Beyan
Not applicable
Kaynakça
- Demirdogen F, Ozdemir G, Akcay G, Iyigun I. Effects of serum vaspin level on infarct volume and severity in patients with acute ischemic stroke. Med Science 2023;12:783-790.
- Akçay G, Aslan M, Kipmen DK, Çeker T, Akan E, Derin N. Effects of transcranial direct current stimulation on the glutamatergic pathway in the male rat hippocampus after experimental focal cerebral ischemia. Journal of Neuroscience Research 2024;102(1).
- Akçay G. Cerebral ischemia model created by transient middle cerebral artery occlusion. Turkish Bulletin of Hygiene and Experimental Biology 2021; 78:205-218.
- GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019;18:459-480
- Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317-1329.
- Dávalos A, Shuaib A, Wahlgren NG. Neurotransmitters and pathophysiology of stroke: evidence for the release of glutamate and other transmitters/mediators in animals and humans. J Stroke Cerebrovasc Dis 2000;9:2-8.
- Heiss WD. The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke. The Johann Jacob Wepfer award 2011. Cerebrovasc Dis 2011;32:307-320.
Therapeutic Effect of Thrombolytic Therapy on Motor Function Loss After Ischaemic Stroke: A Case Study
Öz
Stroke is a serious cerebrovascular disease that can cause disability and death if not treated with appropriate treatment methods at the right time. In ischaemic stroke, recombinant tissue plasminogen activator (rt-PA) treatment is effective in motor deficit recovery, especially in the first 4.5 hours. In this case study, rt-PA thrombolytic treatment of patients with motor deficit after acute ischaemic stroke aged 58 and 79 years was found to improve the loss of motor function.
Anahtar Kelimeler
Kaynakça
- Demirdogen F, Ozdemir G, Akcay G, Iyigun I. Effects of serum vaspin level on infarct volume and severity in patients with acute ischemic stroke. Med Science 2023;12:783-790.
- Akçay G, Aslan M, Kipmen DK, Çeker T, Akan E, Derin N. Effects of transcranial direct current stimulation on the glutamatergic pathway in the male rat hippocampus after experimental focal cerebral ischemia. Journal of Neuroscience Research 2024;102(1).
- Akçay G. Cerebral ischemia model created by transient middle cerebral artery occlusion. Turkish Bulletin of Hygiene and Experimental Biology 2021; 78:205-218.
- GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019;18:459-480
- Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317-1329.
- Dávalos A, Shuaib A, Wahlgren NG. Neurotransmitters and pathophysiology of stroke: evidence for the release of glutamate and other transmitters/mediators in animals and humans. J Stroke Cerebrovasc Dis 2000;9:2-8.
- Heiss WD. The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke. The Johann Jacob Wepfer award 2011. Cerebrovasc Dis 2011;32:307-320.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri (Diğer) |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Haziran 2024 |
| Gönderilme Tarihi | 12 Ocak 2024 |
| Kabul Tarihi | 11 Mart 2024 |
| Yayımlandığı Sayı | Yıl 2024 Cilt: 6 Sayı: 2 |
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