TY  - JOUR
T1  - Side Effect of Lamotrigine in the Emergency Department; Stevens-Johnson Syndrome
TT  - Acil Servise Lamotrijinin Yan Etkisi ile Başvuru; Stevens Johnson Sendromu
AU  - Eliaçık, Sinan
PY  - 2022
DA  - March
DO  - 10.54996/anatolianjem.1015618
JF  - Anatolian Journal of Emergency Medicine
JO  - Anatolian J Emerg Med
PB  - Türkiye Acil Tıp Derneği
WT  - DergiPark
SN  - 2651-4311
SP  - 31
EP  - 33
VL  - 5
IS  - 1
LA  - en
AB  - Aim: Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) is a life-threatening mucocutaneous skin reaction that usually develops against drugs, although there are various factors in its etiology. In this case report, SJS due to antiepileptic drug use will be briefly reviewed.Case:20-year-old female patient was seen in the emergency department with a generalized tonic-clonic seizure. With the detailed anamnesis and laboratory findings obtained, the patient was started lamothyrigine therapy. While the dose was titrated in the treatment, treatment was stopped in the patient who developed SJS, and a new antiepileptic drug was started.Conclusion: SJS/TEN is the same disease spectrum with different severity. They are classified according to the percentage of skin detachment area. The pathogenesis of SJS/TEN is still unclear and optimal treatment options are still controversial.
KW  - Stevens Johnson Syndrome
KW  - toxic epidermel necrolysis
KW  - lamotirigine
N2  - Amaç: Stevens Johnson Sendromu ve Toksik Epidermal Nekroliz (SJS/TEN), hayatı tehdit edebilen, etiyolojisinde çeşitli faktörler olmakla birlikte genellikle ilaçlara karşı gelişen mukokutanöz cilt reaksiyonudur. Bu vaka sunumu ile anti-epileptik ilaç kullanımına bağlı gelişen SJS kısaca gözden geçirilecektir.Olgu: 20 yaşında kadın hasta jeneralize tonik klonik nöbet ile acil serviste görüldü. Alınan ayrıntılı anamnez ve laboratuvar bulguları ile hastaya lamotirijin tedavisi başlandı. Tedavide doz titre edilirken SJS gelişen hastada tedavi kesilerek yeni anti-epileptik ilaç başlandı.Sonuç: SJS/TEN farklı şiddette olan aynı hastalık spektrumudur. Cilt dekolmanı alanının yüzdesine göre sınıflanırlar. SJS/TEN’in patogenezi hala belirsizdir ve optimal tedavi seçenekleri tartışmalıdır. Etiyolojide sıkça ilaçlar sorumlu tutulmaktadır.
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UR  - https://doi.org/10.54996/anatolianjem.1015618
L1  - http://dergipark.org.tr/tr/download/article-file/2050088
ER  -