@article{article_1020749, title={Effects of Grape Seed and Soybean Extracts on Lipid Peroxidation in Streptozotocin Induced Rats}, journal={KTO Karatay Üniversitesi Sağlık Bilimleri Dergisi}, volume={3}, pages={1–9}, year={2022}, author={Gülbahçe Mutlu, Elif and Arslan, Emine and Arikoglu, Hilal and Çalışkan Sak, Kaniye Zeynep and Varol, Salih}, keywords={Deneysel Diabetes Mellitus, Üzüm Çekirdeği Ekstresi, Lipid peroksidasyonu, Soya fasulyesi, Streptozotosin}, abstract={Objective: Recently, the importance of lipid peroxidation in diabetes mellitus, which is characterized by insufficient insulin secretion and impacts, has been reported. To treat this disease, studies have applied herbal treatments and antioxidant agents. The aim of this study determine the possible effects of grape seed and soybean extracts on lipid peroxidation in streptozotocin (STZ)-induced diabetic rats. Method: The rats were divided into 8 groups: control, diabetic control, and 6 extract groups [grape seed (100 mg/kg, 200 mg/kg, and 400 mg/kg dosages) and soybean (100 mg/kg, 200 mg/kg, and 400 mg/kg dosages)]. The first group (control group) was fed a normal diet. The diabetic groups (groups 2, 3, 4, 5, 6, 7, and 8) were fed a high-fat diet, and Diabetes Mellitus was induced by a single intraperitoneal injection of 35 mg/kg STZ. Afterward, extracts were given orally at the indicated dosages to the corresponding treatment groups for 28 days using a gastric tube. At the end of the treatment, liver and pancreatic tissues were collected, and lipid peroxidation parameters and malondialdehyde (MDA) and glutathione (GSH) levels were measured by a spectrophotometric method. Results: For both tissues, MDA levels in the diabetic control group were high, while GSH levels were low. In the treatment groups, MDA levels decreased and GSH levels increased dose-dependently (p < 0.05). Conclusions: According to our results, grape seed and soy extracts can prevent damage caused by lipid peroxidation in diabetes.}, number={1}, publisher={KTO Karatay Üniversitesi}