TY  - JOUR
T1  - BÖBREK İSKEMİ-REPERFÜZYON HASARINDA KALPAİN İNHİBİTÖRÜ OLAN AK295 UYGULANAN SIÇANLARDA SERUM ÜRE VE KREATİN DEĞERLERİ
TT  - Serum Urea and Creatin Values in Rats Administered with AK295, a Calpain Inhibitor, in Renal Ischemia-Reperfusion Injury
AU  - Aydemir, Songül
AU  - Binen, Mahmut
PY  - 2022
DA  - March
Y2  - 2022
DO  - 10.33715/inonusaglik.1021152
JF  - İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi
JO  - JHVS
PB  - İnönü Üniversitesi
WT  - DergiPark
SN  - 2147-7892
SP  - 335
EP  - 344
VL  - 10
IS  - 1
LA  - tr
AB  - Nekroz ve apoptoz gibi hücre ölümü ile sonuçlanan olaylarda kalpainler, kaspazlarla birlikte çalışan proteazlardır. Sıçan omurilik travma modellerinde kalpain inhibitörlerinin (AK295) apoptozu yavaşlattığı veya durdurduğu bilinmektedir. Bu çalışmada 28 adet erkek wistar albino sıçan rastgele seçilerek dört gruba ayrıldı. Gruplar; kontrol, İskemi-Reperfüzyon (İ/R), İskemi-Reperfüzyon+AK295, İskemi-Reperfüzyon+DMSO (dimetil sülfoksit) olarak belirlendi. İskemi sonrasında böbreklerde oluşan hasarda kalpain inhibitörü olan AK295’in etkisi incelendi. Sıçanlara sağ böbrek nefrektomisi uygulanarak 30 dakika total iskemi yapıldı. 24 saatlik reperfüzyon periyodu tamamlandıktan sonra anestezi uygulandı. Bu çalışmamızda, böbrek hasarında önemli indikatörler olan serum kreatin ve üre değerleri tayin edildi. Kontrol, I/R, I/R + AK295, and I/R + DMSO gruplarında ortalama üre değerleri; sırasıyla 35.4 ± 22.3, 156.4 ± 9.01, 150.8 ± 5.8, ve 165.2 ± 6.1 mg/dL olarak bulundu. İ/R + AK295 ve İ/R + DMSO değerlerinin, kontrol grubuna göre anlamlı (p<0.05) derecede yüksek olduğu bulunmuştur. Böbrekte İ/R oluşturulan sıçanlarda, AK295’in oluşan böbrek hasarını kısmen azalttığı tespit edildi.
KW  - AK295
KW  - Böbrek
KW  - İskemi-Reperfüzyon
KW  - Kalpain inhibitörü
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UR  - https://doi.org/10.33715/inonusaglik.1021152
L1  - https://dergipark.org.tr/tr/download/article-file/2071701
ER  -