TY - JOUR T1 - Nadir Bir Hemolitik Üremik Sendrom Nedeni: Salmonella Typhii TT - A Rare Cause of Hemolytic Uremic Syndrome: Salmonella Typhii AU - Ozturk, İlyas AU - Gök, Serdal AU - Saylak, Hatice Kübra AU - Erken, Ertuğrul AU - Altunören, Orçun AU - Güngör, Özkan PY - 2023 DA - March Y2 - 2022 DO - 10.17517/ksutfd.1026255 JF - Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi JO - KSU Medical Journal PB - Kahramanmaraş Sütçü İmam Üniversitesi WT - DergiPark SN - 1303-6610 SP - 209 EP - 211 VL - 18 IS - 1 LA - tr AB - Hemolitik üremik sendrom (HÜS), mikroanjiyopatik hemolitik anemi, trombositopeni ve akut böbrek yetmezliği ile karakterize olan ciddi bir hastalıktır. Hızlı tanı konulup uygun tedavi başlanmadığı takdirde ölümcül seyredebilir. Etyolojide enfeksiyöz ajanlar sıklıkla suçlanmaktadır. Genellikle verositotoksin (Shiga benzeri toksin) üreten mikroorganizmalara bağlı enfeksiyonlar etyolojide önemli yer almaktadır. Bu enfeksiyonlardan sorumlu patojenler çoğunlukla Enterohemorajik Escherichia coli (EHEC), Shigella dysanteria tip 1, nadir olarak da Citrobacter freundi olarak bildirilmiştir. Daha nadir olarak Streptococ-cus pneumoniae, HIV, Clostiridium difficile’ye bağlı HÜS vakaları literatürde bildirilmiştir. Bu olgu, 28 yaşındaki erkek hastada gelişen HÜS tablosunun etyolojisinde çok nadir görülen bir etken olan Salmonella Typhii’nin tespit edilmesi nedeniyle sunulmuştur. KW - Hemolitik üremik sendrom KW - Enfeksiyon KW - Salmonella N2 - Hemolytic uremic syndrome (HUS) is a serious disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. If an appropriate diagnosis and treatment is not initiated, it can be fatal. Infectious agents are generally blamed in the etiology. Generally, infections due to microorganisms producing verocytotoxin (Shiga-like toxin) take an important place in etiology. Pathogens responsible for these infections were mostly reported as Enterohemorrhagic Escherichia coli (EHEC), Shigella dysanteria type 1, and less frequently as Citrobacter freundi. More rarely, HUS cases due to Streptococcus pneumoniae, HIV, Clostiridium difficile have been reported in the literature. This case is presented because of the detection of Salmonella Typhii, as a very rare factor in the etiology of HUS, which developed in a 28-year-old male patient. CR - Noris M, Remuzzi G. Hemolytic uremic syndrome. J Am Soc Nephrol. 2005;16(4):1035-1050. CR - Ruggenenti P, Noris M, Remuzzi G. Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int. 2001;60(3):831-846. CR - Albaqali A, Ghuloom A, Al Arrayed A, Al Ajami A, Shome DK, Jamsheer A et al. Hemolytic uremic syndrome in association with typhoid fever. Am J Kidney Dis. 2003;41(3):709-713. CR - Butani L. Hemolytic uremic syndrome associated with Clostridium difficile colitis. Pediatr Nephrol. 2004;19(12):1430. CR - Mele C, Remuzzi G, Noris M. Hemolytic uremic syndrome. Semin Immunopathol; 2014;36:399–420. CR - Acheson D, Hohmann EL. Nontyphoidal salmonellosis. Clin Infect Dis. 2001;32(2):263-269. CR - Boyce TG, Swerdlow DL, Griffin PM. Escherichia coli O157: H7 and the hemolytic–uremic syndrome. NEJM. 1995;333(6):364-368. CR - Flores FX, Jabs K, Thorne GM, Jaeger J, Linshaw MA, Somers MJ. Immune response to Escherichia coli O157: H7 in hemolytic uremic syndrome following salmonellosis. Pediatr Nephrol. 1997;11(4):488-490. CR - George P. & Pawar B. A sinister presentation of typhoid fever. Indian J Nephrol. 2007;17(4), 176-177. CR - Baker NM, Mills AE, Rachman I, Thomas JE. Haemolytic Uraemic Syndrame in Typhoid fever. Br Med J. 1974;2:84-87 CR - Keenswijk W, Degraeuwe E, Dhont E, Raes A, Vande Walle J. Hemolytic uremic syndrome associated with non–shigatoxin-producing infectious agents: Expanding the Shigatoxin theory. J Pediatr Hematol Oncol. 2019;41(3):179-181. CR - Wong CS, Jelacic S, Habeeb RL, Watkins SL, Tarr PI. The risk of the hemolytic–uremic syndrome after antibiotic treatment of Escherichia coli O157: H7 infections. NEJM. 2000;342(26):1930-1936. UR - https://doi.org/10.17517/ksutfd.1026255 L1 - http://dergipark.org.tr/tr/download/article-file/2091335 ER -