@article{article_1030649, title={A rare entity: Richter transformation presented with spontaneous tibia fracture}, journal={Uluslararası Modern Sağlık Bilimleri Dergisi}, volume={2}, pages={41–43}, year={2021}, author={Tığlıoğlu, Pınar and Albayrak, Murat and Yıldız, Abdulkerim and Sağlam, Buğra and Reis Aras, Merih and Afacan Öztürk, Hacer Berna and Maral, Senem}, keywords={Kemik lezyonu, Kronik lenfositik lösemi, lenfoma, Ritchter sendromu}, abstract={Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) /small lymphocytic lymphoma into an aggressive lymphoid malignancy. The incidence of RS varies from 1% to 9% and it is generally characterized by an aggressive clinical course. The case is here reported of CLL patient with RS and its unique presentation with bone involvement. RS is a heterogeneus condition that is characterised by an aggressive presentation, with low treatment response rates and and very poor survival. Lymph node and bone marrow are mainly involved but extra-nodal involvement is also observed. Our patient is the first case of RS with bone involvement.}, number={2}, publisher={DNT Ortadoğu Yayıncılık A.Ş.}